8W6Z
| Substrate-bound crystal structure of a P450 enzyme DmlH that catalyze intramolecular phenol coupling in the biosynthesis of cihanmycins | 分子名称: | (E)-3-[2-[(2R,3S)-3-[(1R)-1-aminocarbonyloxypropyl]oxiran-2-yl]phenyl]prop-2-enoic acid, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Fang, C, Zhang, L, Zhu, Y, Zhang, C. | 登録日 | 2023-08-30 | 公開日 | 2024-06-12 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Substrate-bound crystal structure of a P450 enzyme DmlH that catalyze intramolecular phenol coupling in the biosynthesis of cihanmycins To Be Published
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1S79
| Solution structure of the central RRM of human La protein | 分子名称: | Lupus La protein | 著者 | Alfano, C, Sanfelice, D, Babon, J, Kelly, G, Jacks, A, Curry, S, Conte, M.R. | 登録日 | 2004-01-29 | 公開日 | 2004-04-06 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. Nat.Struct.Mol.Biol., 11, 2004
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1QQQ
| CRYSTAL STRUCTURE ANALYSIS OF SER254 MUTANT OF ESCHERICHIA COLI THYMIDYLATE SYNTHASE | 分子名称: | SULFATE ION, THYMIDYLATE SYNTHASE | 著者 | Fantz, C, Shaw, D, Jennings, W, Forsthoefel, A, Kitchens, M, Phan, J, Minor, W, Lebioda, L, Berger, F.G, Spencer, H.T. | 登録日 | 1999-06-07 | 公開日 | 1999-06-14 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254. Mol.Pharmacol., 57, 2000
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1S7A
| NMR structure of the La motif of human La protein | 分子名称: | Lupus La protein | 著者 | Alfano, C, Sanfelice, D, Babon, J, Kelly, G, Jacks, A, Curry, S, Conte, M.R. | 登録日 | 2004-01-29 | 公開日 | 2004-04-06 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. Nat.Struct.Mol.Biol., 11, 2004
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1IOV
| COMPLEX OF D-ALA:D-ALA LIGASE WITH ADP AND A PHOSPHORYL PHOSPHONATE | 分子名称: | 2-[(1-AMINO-ETHYL)-PHOSPHATE-PHOSPHINOYLOXY]-BUTYRIC ACID, ADENOSINE-5'-DIPHOSPHATE, D-ALA:D-ALA LIGASE, ... | 著者 | Knox, J.R, Moews, P.C, Fan, C. | 登録日 | 1996-09-20 | 公開日 | 1997-02-12 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | D-alanine:D-alanine ligase: phosphonate and phosphinate intermediates with wild type and the Y216F mutant. Biochemistry, 36, 1997
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1IOW
| COMPLEX OF Y216F D-ALA:D-ALA LIGASE WITH ADP AND A PHOSPHORYL PHOSPHINATE | 分子名称: | 1(S)-AMINOETHYL-(2-CARBOXYPROPYL)PHOSPHORYL-PHOSPHINIC ACID, ADENOSINE-5'-DIPHOSPHATE, D-ALA:D-ALA LIGASE, ... | 著者 | Knox, J.R, Moews, P.C, Fan, C. | 登録日 | 1996-09-20 | 公開日 | 1997-02-12 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | D-alanine:D-alanine ligase: phosphonate and phosphinate intermediates with wild type and the Y216F mutant. Biochemistry, 36, 1997
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7S7V
| Crystal structure of iNicSnFR3a Fluorescent Nicotine Sensor | 分子名称: | iNicSnFR 3.0 Fluorescent Nicotine Sensor | 著者 | Fan, C, Shivange, A.V, Looger, L.L, Lester, H.A, Rees, D.C. | 登録日 | 2021-09-17 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife, 11, 2022
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7S7T
| iNicSnFR3a Nicotine Sensor comprising Periplasmic Binding sequence plus Fluorescent Sequence with varenicline bound | 分子名称: | IODIDE ION, VARENICLINE, iNicSnFR 3.0 Fluorescent Nicotine Sensor | 著者 | Fan, C, Shivange, A.V, Looger, L.L, Lester, H.A, Rees, D.C. | 登録日 | 2021-09-17 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife, 11, 2022
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7S7U
| Crystal structure of iNicSnFR3a Fluorescent Nicotine Sensor with nicotine bound | 分子名称: | iNicSnFR 3.0 Fluorescent Nicotine Sensor | 著者 | Fan, C, Shivange, A.V, Looger, L.L, Lester, H.A, Rees, D.C. | 登録日 | 2021-09-17 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife, 11, 2022
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7SC1
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3JAU
| The cryoEM map of EV71 mature viron in complex with the Fab fragment of antibody D5 | 分子名称: | Capsid protein VP1, Heavy chain of Fab fragment variable region of antibody D5, Light chain of Fab fragment variable region of antibody D5 | 著者 | Fan, C, Ye, X.H, Ku, Z.Q, Zuo, T, Kong, L.L, Zhang, C, Shi, J.P, Liu, Q.W, Chen, T, Zhang, Y.Y, Jiang, W, Zhang, L.Q, Huang, Z, Cong, Y. | 登録日 | 2015-06-24 | 公開日 | 2016-02-10 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody Plos Pathog., 12, 2016
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2DLN
| VANCOMYCIN RESISTANCE: STRUCTURE OF D-ALANINE:D-ALANINE LIGASE AT 2.3 ANGSTROMS RESOLUTION | 分子名称: | 1(S)-AMINOETHYL-(2-CARBOXYPROPYL)PHOSPHORYL-PHOSPHINIC ACID, ADENOSINE-5'-DIPHOSPHATE, D-ALANINE--D-ALANINE LIGASE, ... | 著者 | Knox, J.R, Moews, P.C, Fan, C. | 登録日 | 1994-07-18 | 公開日 | 1995-11-01 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Vancomycin resistance: structure of D-alanine:D-alanine ligase at 2.3 A resolution. Science, 266, 1994
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6CUD
| Structure of the human TRPC3 in a lipid-occupied, closed state | 分子名称: | (2R)-3-hydroxypropane-1,2-diyl dihexanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Lu, W, Du, J, Fan, C, Choi, W. | 登録日 | 2018-03-25 | 公開日 | 2018-05-16 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of the human lipid-gated cation channel TRPC3. Elife, 7, 2018
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6V1R
| Crystal structure of iAChSnFR Fluorescent Acetylcholine Sensor precursor binding protein | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ACETYLCHOLINE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Fan, C, Borden, P.M, Looger, L.L, Lester, H.A, Rees, D.C. | 登録日 | 2019-11-21 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | A genetically encoded fluorescent sensor for in vivo acetylcholine detection To Be Published
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8FYI
| Structure of HIV-1 BG505 SOSIP-HT1 in complex with one CD4 molecule | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(6-8)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, C, Dam, K.A, Bjorkman, P.J. | 登録日 | 2023-01-26 | 公開日 | 2023-10-18 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Intermediate conformations of CD4-bound HIV-1 Env heterotrimers. Nature, 623, 2023
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8FYJ
| Structure of HIV-1 BG505 SOSIP-HT2 in complex with two CD4 molecules (class I) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | 著者 | Fan, C, Dam, K.A, Bjorkman, P.J. | 登録日 | 2023-01-26 | 公開日 | 2023-10-18 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Intermediate conformations of CD4-bound HIV-1 Env heterotrimers. Nature, 623, 2023
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4WGI
| A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1) | 分子名称: | (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid, FORMIC ACID, MAGNESIUM ION, ... | 著者 | Clifton, M.C, Fairman, J.W, Fang, C, D'Souza, B, Fulroth, B, Leed, A, McCarren, P, Wang, L, Wang, Y, Kaushik, V, Palmer, M, Wei, G, Golub, T.R, Hubbard, B.K, Serrano-Wu, M.H. | 登録日 | 2014-09-18 | 公開日 | 2014-11-19 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1). Acs Med.Chem.Lett., 5, 2014
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8SGO
| Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Legesse, D.H, Fan, C, Teng, J, Zhuang, Y, Howard, R.J, Noviello, C.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2023-04-12 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Structural insights into opposing actions of neurosteroids on GABA A receptors. Nat Commun, 14, 2023
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7BW7
| Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin. | 分子名称: | Insulin fusion, Insulin receptor | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | 登録日 | 2020-04-13 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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7BW8
| Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin | 分子名称: | Insulin fusion, Insulin receptor | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | 登録日 | 2020-04-14 | 公開日 | 2021-04-14 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor To Be Published
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7QA9
| 10bp DNA/DNA duplex | 分子名称: | DNA (5'-D(*CP*CP*AP*TP*TP*AP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*TP*AP*AP*TP*GP*G)-3') | 著者 | Li, Q, Trajkovski, M, Fan, C, Chen, J, Zhou, Y, Lu, K, Li, H, Su, X, Xi, Z, Plavec, J, Zhou, C. | 登録日 | 2021-11-16 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | 4'-SCF 3 -Labeling Constitutes a Sensitive 19 F NMR Probe for Characterization of Interactions in the Minor Groove of DNA. Angew.Chem.Int.Ed.Engl., 61, 2022
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2QFJ
| Crystal Structure of First Two RRM Domains of FIR Bound to ssDNA from a Portion of FUSE | 分子名称: | DNA (5'-D(*DTP*DCP*DGP*DGP*DGP*DAP*DTP*DTP*DTP*DTP*DTP*DTP*DAP*DTP*DTP*DTP*DTP*DGP*DTP*DGP*DTP*DTP*DAP*DTP*DT)-3'), FBP-interacting repressor | 著者 | Crichlow, G.V, Yang, Y, Fan, C, Lolis, E, Braddock, D. | 登録日 | 2007-06-27 | 公開日 | 2008-03-04 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition EMBO J., 27, 2007
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4DJK
| Structure of glutamate-GABA antiporter GadC | 分子名称: | Probable glutamate/gamma-aminobutyrate antiporter | 著者 | Ma, D, Lu, P.L, Yan, C.Y, Fan, C, Yin, P, Wang, J.W, Shi, Y.G. | 登録日 | 2012-02-02 | 公開日 | 2012-03-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.097 Å) | 主引用文献 | Structure and mechanism of a glutamate-GABA antiporter Nature, 483, 2012
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4DJI
| Structure of glutamate-GABA antiporter GadC | 分子名称: | Probable glutamate/gamma-aminobutyrate antiporter | 著者 | Ma, D, Lu, P.L, Yan, C.Y, Fan, C, Yin, P, Wang, J.W, Shi, Y.G. | 登録日 | 2012-02-02 | 公開日 | 2012-03-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.187 Å) | 主引用文献 | Structure and mechanism of a glutamate-GABA antiporter Nature, 483, 2012
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4HED
| Zebrafish chemokine CXL1 | 分子名称: | Uncharacterized protein | 著者 | Rajasekaran, D, Fan, C, Meng, W, Pflugrath, J.W, Lolis, E.J. | 登録日 | 2012-10-03 | 公開日 | 2013-08-21 | 最終更新日 | 2014-04-23 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Structural insight into the evolution of a new chemokine family from zebrafish. Proteins, 82, 2014
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