7S7T

iNicSnFR3a Nicotine Sensor comprising Periplasmic Binding sequence plus Fluorescent Sequence with varenicline bound

Summary for 7S7T

Entry DOI	10.2210/pdb7s7t/pdb
Descriptor	iNicSnFR 3.0 Fluorescent Nicotine Sensor, VARENICLINE, IODIDE ION (3 entities in total)
Functional Keywords	nicotine, gfp, periplasmic binding protein, nicotine-binding protein, fluorescent sensor, pharmacokinetic sensor, choline-binding protein, fluorescent protein
Biological source	Thermoanaerobacter sp. X513
Total number of polymer chains	1
Total formula weight	61302.04
Authors	Fan, C.,Shivange, A.V.,Looger, L.L.,Lester, H.A.,Rees, D.C. (deposition date: 2021-09-17, release date: 2021-10-13, Last modification date: 2023-11-15)
Primary citation	Nichols, A.L.,Blumenfeld, Z.,Fan, C.,Luebbert, L.,Blom, A.E.M.,Cohen, B.N.,Marvin, J.S.,Borden, P.M.,Kim, C.H.,Muthusamy, A.K.,Shivange, A.V.,Knox, H.J.,Campello, H.R.,Wang, J.H.,Dougherty, D.A.,Looger, L.L.,Gallagher, T.,Rees, D.C.,Lester, H.A. Correction: Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands. Elife, 11:-, 2022 Cited by PubMed: 36520038 DOI: 10.7554/eLife.85479 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation