1CIY
 
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7LSV
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6UXE
 | | Structure of the human mitochondrial desulfurase complex Nfs1-ISCU2(M140I)-ISD11 with E.coli ACP1 at 1.57 A resolution showing flexibility of N terminal end of ISCU2 | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... | | 著者 | Boniecki, M.T, Cygler, M. | | 登録日 | 2019-11-07 | | 公開日 | 2019-11-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
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7UPS
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7TZK
 | | EPS8 SH3 Domain with NleH1 PxxDY Motif | | 分子名称: | Epidermal growth factor receptor kinase substrate 8, T3SS secreted effector NleH homolog | | 著者 | Grishin, A.M, Cygler, M. | | 登録日 | 2022-02-15 | | 公開日 | 2022-07-06 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic E. coli
Proc.Natl.Acad.Sci.USA, 119, 2022
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6W1D
 | | Structure of human mitochondrial complex Nfs1-ISCU2 (WT)-ISD11 with E.coli ACP1 at 1.8 A resolution (NIAU)2 | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... | | 著者 | Boniecki, M.T, Cygler, M. | | 登録日 | 2020-03-04 | | 公開日 | 2020-03-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | | 主引用文献 | The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
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1DIB
 | | HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY345899 | | 分子名称: | 4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMI C ACID, METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Schmidt, A, Wu, H, MacKenzie, R.E, Chen, V.J, Bewly, J.R, Ray, J.E, Toth, J.E, Cygler, M. | | 登録日 | 1999-11-29 | | 公開日 | 2000-07-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.
Biochemistry, 39, 2000
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1DIG
 | | HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY374571 | | 分子名称: | ACETATE ION, METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Schmidt, A, Wu, H, MacKenzie, R.E, Chen, V.J, Bewly, J.R, Ray, J.E, Toth, J.E, Cygler, M. | | 登録日 | 1999-11-29 | | 公開日 | 2000-07-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.
Biochemistry, 39, 2000
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1DIA
 | | HUMAN METHYLENETETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE COMPLEXED WITH NADP AND INHIBITOR LY249543 | | 分子名称: | METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [[[2-AMINO-5,6,7,8-TETRAHYDRO-4-HYDROXY-PYRIDO[2,3-D]PYRIMIDIN-6-YL]-ETHYL]-PHENYL]-CARBONYL-GLUTAMIC ACID | | 著者 | Schmidt, A, Wu, H, MacKenzie, R.E, Chen, V.J, Bewly, J.R, Ray, J.E, Toth, J.E, Cygler, M. | | 登録日 | 1999-11-29 | | 公開日 | 2000-07-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.
Biochemistry, 39, 2000
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1A4I
 | | HUMAN TETRAHYDROFOLATE DEHYDROGENASE / CYCLOHYDROLASE | | 分子名称: | METHYLENETETRAHYDROFOLATE DEHYDROGENASE / METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Allaire, M, Li, Y, Mackenzie, R.E, Cygler, M. | | 登録日 | 1998-01-30 | | 公開日 | 1999-02-09 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase bifunctional enzyme at 1.5 A resolution.
Structure, 6, 1998
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5CPC
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5CQ9
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6WI2
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6WIH
 | | N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2. | | 分子名称: | 1,2-ETHANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Acyl carrier protein, ... | | 著者 | Boniecki, M.T, Cygler, M. | | 登録日 | 2020-04-09 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
To Be Published
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1CJL
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6MCP
 | | L. pneumophila effector kinase LegK7 (AMP-PNP bound) in complex with human MOB1A | | 分子名称: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, LegK7, ... | | 著者 | Beyrakhova, K.A, Xu, C, Boniecki, M.T, Cygler, M. | | 登録日 | 2018-09-01 | | 公開日 | 2019-09-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6MCQ
 | | L. pneumophila effector kinase LegK7 in complex with human MOB1A | | 分子名称: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, LegK7, ... | | 著者 | Beyrakhova, K.A, Xu, C, Boniecki, M.T, Cygler, M. | | 登録日 | 2018-09-01 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.
Proc.Natl.Acad.Sci.USA, 117, 2020
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1AC5
 | | CRYSTAL STRUCTURE OF KEX1(DELTA)P, A PROHORMONE-PROCESSING CARBOXYPEPTIDASE FROM SACCHAROMYCES CEREVISIAE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, KEX1(DELTA)P | | 著者 | Shilton, B.H, Thomas, D.Y, Cygler, M. | | 登録日 | 1997-02-13 | | 公開日 | 1997-05-15 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of Kex1deltap, a prohormone-processing carboxypeptidase from Saccharomyces cerevisiae.
Biochemistry, 36, 1997
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1TRH
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5JMF
 | | Heparinase III-BT4657 gene product | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Heparinase III protein, ... | | 著者 | Ulaganathan, T.S, Shi, R, Yao, D, Garron, M.-L, Cherney, M, Cygler, M. | | 登録日 | 2016-04-28 | | 公開日 | 2016-05-25 | | 最終更新日 | 2018-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.854 Å) | | 主引用文献 | Conformational flexibility of PL12 family heparinases: structure and substrate specificity of heparinase III from Bacteroides thetaiotaomicron (BT4657).
Glycobiology, 27, 2017
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5JMD
 | | Heparinase III-BT4657 gene product, Methylated Lysines | | 分子名称: | Heparinase III protein, MAGNESIUM ION | | 著者 | Ulaganathan, T.S, Shi, R, Yao, D, Garron, M.-L, Cherney, M, Cygler, M. | | 登録日 | 2016-04-28 | | 公開日 | 2016-05-25 | | 最終更新日 | 2018-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Conformational flexibility of PL12 family heparinases: structure and substrate specificity of heparinase III from Bacteroides thetaiotaomicron (BT4657).
Glycobiology, 27, 2017
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6DUS
 | | Structure of Salmonella Effector SseK3 E258Q mutant | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Chung, I.Y.W, Cygler, M. | | 登録日 | 2018-06-21 | | 公開日 | 2018-07-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways.
Mol.Cell Proteomics, 18, 2019
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1K94
 | | Crystal structure of des(1-52)grancalcin with bound calcium | | 分子名称: | CALCIUM ION, GRANCALCIN | | 著者 | Jia, J, Borregaard, N, Lollike, K, Cygler, M. | | 登録日 | 2001-10-26 | | 公開日 | 2001-12-07 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure of Ca(2+)-loaded human grancalcin.
Acta Crystallogr.,Sect.D, 57, 2001
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1K95
 | | Crystal structure of des(1-52)grancalcin with bound calcium | | 分子名称: | GRANCALCIN | | 著者 | Jia, J, Borregaard, N, Lollike, K, Cygler, M. | | 登録日 | 2001-10-26 | | 公開日 | 2001-12-07 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of Ca(2+)-loaded human grancalcin.
Acta Crystallogr.,Sect.D, 57, 2001
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1MFA
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