8Q63
 
 | | Cryo-EM structure of IC8', a second state of yeast mitochondrial RNA polymerase transcription initiation complex with 8-mer RNA, pppGpGpUpApApApUpG | | 分子名称: | DNA-directed RNA polymerase, mitochondrial, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Goovaerts, Q, Shen, J, Patel, S.S, Das, K. | | 登録日 | 2023-08-10 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | Structures illustrate step-by-step mitochondrial transcription initiation.
Nature, 622, 2023
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1ON0
 | | Crystal Structure of Putative Acetyltransferase (YycN) from Bacillus subtilis, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR144 | | 分子名称: | CHLORIDE ION, SULFATE ION, YycN protein | | 著者 | Forouhar, F, Shen, J, Kuzin, A, Chiang, Y, Xiao, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2003-02-26 | | 公開日 | 2003-03-11 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal Structure of Putative Acetyltransferase (YycN) from Bacillus subtilis
To be Published
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1T5I
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3CGY
 | | Crystal Structure of Salmonella Sensor Kinase PhoQ catalytic domain in complex with radicicol | | 分子名称: | RADICICOL, Virulence sensor histidine kinase phoQ | | 著者 | Guarnieri, M.T, Zhang, L, Shen, J, Zhao, R. | | 登録日 | 2008-03-06 | | 公開日 | 2008-05-13 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ.
J.Mol.Biol., 379, 2008
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3CGZ
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2P8R
 | | Crystal structure of the C-terminal domain of C. elegans pre-mRNA splicing factor Prp8 carrying R2303K mutant | | 分子名称: | Pre-mRNA-splicing factor Prp8 | | 著者 | Zhang, L, Shen, J, Guarnieri, M.T, Heroux, A, Yang, K, Zhao, R. | | 登録日 | 2007-03-22 | | 公開日 | 2007-05-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants
Protein Sci., 16, 2007
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2P87
 | | Crystal structure of the C-terminal domain of C. elegans pre-mRNA splicing factor Prp8 | | 分子名称: | Pre-mRNA-splicing factor Prp8 | | 著者 | Zhang, L, Shen, J, Guarnieri, M.T, Heroux, A, Yang, K, Zhao, R. | | 登録日 | 2007-03-21 | | 公開日 | 2007-05-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants
Protein Sci., 16, 2007
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4NKJ
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2LUH
 | | NMR structure of the Vta1-Vps60 complex | | 分子名称: | Vacuolar protein sorting-associated protein VTA1, Vacuolar protein-sorting-associated protein 60 | | 著者 | Yang, Z, Vild, C, Ju, J, Zhang, X, Liu, J, Shen, J, Zhao, B, Lan, W, Gong, F, Liu, M, Cao, C, Xu, Z. | | 登録日 | 2012-06-13 | | 公開日 | 2012-11-07 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis of Molecular Recognition between ESCRT-III-like Protein Vps60 and AAA-ATPase Regulator Vta1 in the Multivesicular Body Pathway.
J.Biol.Chem., 287, 2012
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2GSW
 | | Crystal Structure of the Putative NADPH-dependent Azobenzene FMN-Reductase YhdA from Bacillus subtilis, Northeast Structural Genomics Target SR135 | | 分子名称: | FLAVIN MONONUCLEOTIDE, yhdA | | 著者 | Forouhar, F, Hussain, M, Jayaraman, S, Shen, J, Cooper, B, Cunningham, K, Janjua, H, Ma, L.-C, Xiao, R, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2006-04-26 | | 公開日 | 2006-05-09 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | Crystal Structure of the Putative NADPH-dependent Azobenzene FMN-Reductase YhdA from Bacillus subtilis, Northeast Structural Genomics Target SR135
To be Published
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2LGK
 | | NMR Structure of UHRF1 PHD domains in a complex with histone H3 peptide | | 分子名称: | E3 ubiquitin-protein ligase UHRF1, ZINC ION, histone H3 peptide | | 著者 | Wang, C, Shen, J, Yang, Z, Chen, P, Zhao, B, Hu, W, Lan, W, Tong, X, Wu, H, Li, G, Cao, C. | | 登録日 | 2011-07-28 | | 公開日 | 2011-09-28 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res., 21, 2011
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2LGG
 | | Structure of PHD domain of UHRF1 in complex with H3 peptide | | 分子名称: | E3 ubiquitin-protein ligase UHRF1, ZINC ION, histone H3 peptide | | 著者 | Wang, C, Shen, J, Yang, Z, Chen, P, Zhao, B, Hu, W, Lan, W, Tong, X, Wu, H, Li, G, Cao, C. | | 登録日 | 2011-07-26 | | 公開日 | 2011-09-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res., 21, 2011
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2LGL
 | | NMR structure of the UHRF1 PHD domain | | 分子名称: | E3 ubiquitin-protein ligase UHRF1, ZINC ION | | 著者 | Wang, C, Shen, J, Yang, Z, Chen, P, Zhao, B, Hu, W, Lan, W, Tong, X, Wu, H, Li, G, Cao, C. | | 登録日 | 2011-07-28 | | 公開日 | 2011-09-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res., 21, 2011
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6JRK
 | | The structure of co-crystals of 8r-B-EGFR WT complex | | 分子名称: | 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3S)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one, Epidermal growth factor receptor | | 著者 | Zhu, S.J, Yun, C.H. | | 登録日 | 2019-04-04 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | | 主引用文献 | Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S).
J.Med.Chem., 62, 2019
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6JRJ
 | | The structure of co-crystals of 8r-B-EGFR T790M/C797S complex | | 分子名称: | 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3S)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one, Epidermal growth factor receptor | | 著者 | Zhu, S.J, Yun, C.H. | | 登録日 | 2019-04-04 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.943 Å) | | 主引用文献 | Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S).
J.Med.Chem., 62, 2019
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4RVZ
 | | Crystal structure of tRNA fluorescent labeling enzyme | | 分子名称: | MAGNESIUM ION, N-(4-aminobutyl)-2-azidoacetamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | 著者 | Dong, J, Li, F, Wang, J, Gong, W. | | 登録日 | 2014-11-29 | | 公開日 | 2015-03-11 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A covalent approach for site-specific RNA labeling in Mammalian cells.
Angew.Chem.Int.Ed.Engl., 54, 2015
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4UMX
 | | IDH1 R132H in complex with cpd 1 | | 分子名称: | 2,6-bis(1H-imidazol-1-ylmethyl)-4-(2,4,4-trimethylpentan-2-yl)phenol, GLYCEROL, ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC, ... | | 著者 | Mathieu, M, Marquette, J.P. | | 登録日 | 2014-05-22 | | 公開日 | 2014-11-19 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (Idh1) Via Disruption of a Metal Binding Network by an Allosteric Small Molecule.
J.Biol.Chem., 290, 2015
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4UMY
 | | IDH1 R132H in complex with cpd 1 | | 分子名称: | GLYCEROL, ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | McLean, L, Zhang, Y, Mathieu, M. | | 登録日 | 2014-05-22 | | 公開日 | 2014-11-19 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (Idh1) Via Disruption of a Metal Binding Network by an Allosteric Small Molecule.
J.Biol.Chem., 290, 2015
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5LRN
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5LRM
 | | Structure of di-zinc MCR-1 in P41212 space group | | 分子名称: | GLYCEROL, ZINC ION, phosphatidylethanolamine transferase Mcr-1 | | 著者 | Hinchliffe, P, Spencer, J. | | 登録日 | 2016-08-19 | | 公開日 | 2016-12-07 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.
Sci Rep, 7, 2017
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2BX4
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2BX3
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4TJX
 | | Crystal structure of protease-associated domain of Arabidopsis VSR1 in complex with aleurain peptide | | 分子名称: | Aleurain peptide, Vacuolar-sorting receptor 1 | | 著者 | Luo, F, Fong, Y.H, Jiang, L.W, Wong, K.B. | | 登録日 | 2014-05-25 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | | 主引用文献 | How vacuolar sorting receptor proteins interact with their cargo proteins: crystal structures of apo and cargo-bound forms of the protease-associated domain from an Arabidopsis vacuolar sorting receptor.
Plant Cell, 26, 2014
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4TJV
 | | Crystal structure of protease-associated domain of Arabidopsis vacuolar sorting receptor 1 | | 分子名称: | IODIDE ION, Vacuolar-sorting receptor 1 | | 著者 | Luo, F, Fong, Y.H, Jiang, L.W, Wong, K.B. | | 登録日 | 2014-05-25 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | | 主引用文献 | How vacuolar sorting receptor proteins interact with their cargo proteins: crystal structures of apo and cargo-bound forms of the protease-associated domain from an Arabidopsis vacuolar sorting receptor.
Plant Cell, 26, 2014
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8X43
 | | human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2 | | 分子名称: | Calmodulin-1, N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | | 著者 | Ma, D, Guo, J. | | 登録日 | 2023-11-15 | | 公開日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | A small-molecule activation mechanism that directly opens the KCNQ2 channel.
Nat.Chem.Biol., 2024
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