8X43

human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2

Summary for 8X43

• Entry DOI: 10.2210/pdb8x43/pdb
• EMDB information: 38041
• Descriptor: Potassium voltage-gated channel subfamily KQT member 2, Calmodulin-1, N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide (3 entities in total)
• Functional Keywords: potassium voltage-gated channel subfamily kqt member 2, ebio1-s1, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 363146.76

Authors

Ma, D.,Guo, J. (deposition date: 2023-11-15, release date: 2024-01-17)

• Primary citation: Zhang, S.,Ma, D.,Wang, K.,Li, Y.,Yang, Z.,Li, X.,Li, J.,He, J.,Mei, L.,Ye, Y.,Chen, Z.,Shen, J.,Hou, P.,Guo, J.,Zhang, Q.,Yang, H.; A small-molecule activation mechanism that directly opens the KCNQ2 channel.; Nat.Chem.Biol., 2024; PubMed: 38167918; DOI: 10.1038/s41589-023-01515-y

Experimental method

ELECTRON MICROSCOPY (3 Å)