8X43

human KCNQ2-CaM-Ebio1-S1 complex in the presence of PIP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G	Potassium voltage-gated channel subfamily KQT member 2	polymer	656	73627.8	4	UniProt (O43526) Pfam (PF00520) Pfam (PF07885) Pfam (PF03520) Pfam (PF16642) In PDB	Homo sapiens (human)	KQT-like 2,Neuroblastoma-specific potassium channel subunit alpha KvLQT2,Voltage-gated potassium channel subunit Kv7.2
2	B, D, F, H	Calmodulin-1	polymer	149	16852.5	4	UniProt (P0DP23) Pfam (PF13499) In PDB	Homo sapiens (human)
3	A, C, E, G	N-(4-azanyl-1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide	non-polymer		306.3	4	Chemie (7Q0)

Sequence modifications

A, C, E, G: 64 - 702 (UniProt: O43526)

PDB	External Database	Details
Met 63	-	initiating methionine
Val 703	-	expression tag
Glu 704	-	expression tag
Gly 705	-	expression tag
Gly 706	-	expression tag
Ser 707	-	expression tag
Ser 708	-	expression tag
Gly 709	-	expression tag
Gly 710	-	expression tag
Trp 711	-	expression tag
Ser 712	-	expression tag
His 713	-	expression tag
Pro 714	-	expression tag
Gln 715	-	expression tag
Phe 716	-	expression tag
Glu 717	-	expression tag
Lys 718	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	361921.4
Non-Polymers*	Number of molecules	4
	Total formula weight	1225.3
All*	Total formula weight	363146.8

*Water molecules are not included.