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6JRJ

The structure of co-crystals of 8r-B-EGFR T790M/C797S complex

Summary for 6JRJ
Entry DOI10.2210/pdb6jrj/pdb
DescriptorEpidermal growth factor receptor, 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3S)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one (3 entities in total)
Functional Keywordsegfr t790m/c797s, inhibitor, complex, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight38092.53
Authors
Zhu, S.J.,Yun, C.H. (deposition date: 2019-04-04, release date: 2020-04-15, Last modification date: 2024-03-27)
Primary citationShen, J.,Zhang, T.,Zhu, S.J.,Sun, M.,Tong, L.,Lai, M.,Zhang, R.,Xu, W.,Wu, R.,Ding, J.,Yun, C.H.,Xie, H.,Lu, X.,Ding, K.
Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFRL858R/T790M/C797S).
J.Med.Chem., 62:7302-7308, 2019
Cited by
PubMed: 31298540
DOI: 10.1021/acs.jmedchem.9b00576
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.943 Å)
Structure validation

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