6JRJ
The structure of co-crystals of 8r-B-EGFR T790M/C797S complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 331 | 37460.4 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3S)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one | non-polymer | 632.2 | 1 | Chemie (C6O) | |||
3 | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 692 | - | expression tag |
Ala 693 | - | expression tag |
Met 694 | - | expression tag |
Gly 695 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Ser 797 | Cys 797 | engineered mutation |
Ala 865 | Glu 865 | engineered mutation |
Ala 866 | Glu 866 | engineered mutation |
Ala 867 | Lys 867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37460.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 632.2 | |
All* | Total formula weight | 38092.5 |