4UMY
IDH1 R132H in complex with cpd 1
Summary for 4UMY
Entry DOI | 10.2210/pdb4umy/pdb |
Related | 4UMX |
Descriptor | ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC, SULFATE ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | oxidoreductase, isocitrate dehydrogenase inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : O75874 |
Total number of polymer chains | 2 |
Total formula weight | 98234.52 |
Authors | McLean, L.,Zhang, Y.,Mathieu, M. (deposition date: 2014-05-22, release date: 2014-11-19, Last modification date: 2024-01-10) |
Primary citation | Deng, G.,Shen, J.,Yin, M.,Mcmanus, J.,Mathieu, M.,Gee, P.,He, T.,Shi, C.,Bedel, O.,Mclean, L.R.,Le-Strat, F.,Zhang, Y.,Marquette, J.,Gao, Q.,Zhang, B.,Rak, A.,Hoffmann, D.,Rooney, E.,Vassort, A.,Englaro, W.,Li, Y.,Patel, V.,Adrian, F.,Gross, S.,Wiederschain, D.,Cheng, H.,Licht, S. Selective Inhibition of Mutant Isocitrate Dehydrogenase 1 (Idh1) Via Disruption of a Metal Binding Network by an Allosteric Small Molecule. J.Biol.Chem., 290:762-, 2015 Cited by PubMed: 25391653DOI: 10.1074/JBC.M114.608497 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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