4UMY

IDH1 R132H in complex with cpd 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC	polymer	425	48135.7	2	UniProt (O75874) Pfam (PF00180) In PDB	HOMO SAPIENS (HUMAN)	IDH, CYTOSOLIC NADP-ISOCITRATE DEHYDROGENASE, IDP, NADP(+)- SPECIFIC ICDH, OXALOSUCCINATE DECARBOXYLASE, IDH1-R132H
2	A, B	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	A, B	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
5		water	water		18.0	286	Chemie (HOH)

Sequence modifications

A, B: 1 - 414 (UniProt: O75874)

PDB	External Database	Details
Ser 415	-	expression tag
Leu 416	-	expression tag
Glu 417	-	expression tag
His 418	-	expression tag
His 419	-	expression tag
His 420	-	expression tag
His 421	-	expression tag
His 422	-	expression tag
His 423	-	expression tag
His 424	-	expression tag
His 425	-	expression tag
His 132	Arg 132	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	96271.4
Non-Polymers*	Number of molecules	7
	Total formula weight	1963.2
All*	Total formula weight	98234.5

*Water molecules are not included.