5ZOL
 
 | | Crystal structure of a three sites mutantion of FSAA complexed with HA and product | | 分子名称: | (3S,4S)-3,4-dihydroxy-4-(thiophen-2-yl)butan-2-one, 1-hydroxypropan-2-one, CHLORIDE ION, ... | | 著者 | Wu, L, Yang, X.H, Yu, H.W, Zhou, J.H. | | 登録日 | 2018-04-13 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.172 Å) | | 主引用文献 | The engineering of decameric d-fructose-6-phosphate aldolase A by combinatorial modulation of inter- and intra-subunit interactions.
Chem.Commun.(Camb.), 56, 2020
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7CMH
 | | The LAT2-4F2hc complex in complex with tryptophan | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | | 著者 | Yan, R.H, Zhou, J.Y, Li, Y.N, Lei, J.L, Zhou, Q. | | 登録日 | 2020-07-27 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.
Cell Discov, 6, 2020
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7CMI
 | | The LAT2-4F2hc complex in complex with leucine | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | | 著者 | Yan, R.H, Zhou, J.Y, Li, Y.N, Lei, J.L, Zhou, Q. | | 登録日 | 2020-07-27 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.
Cell Discov, 6, 2020
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8FYA
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYB
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (17-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYC
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation | | 分子名称: | Cas1, Cas2-DEDDh, DEDDh, ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYD
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation | | 分子名称: | Cas1, Cas2-DEDDh, DNA (13-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FY9
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER) | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8YSA
 | | The co-crystal structure of SARS-CoV-2 Mpro in complex with compound H102 | | 分子名称: | 3C-like proteinase nsp5, BOC-TBG-PHE-ELL | | 著者 | Zheng, W.Y, Fu, L.F, Feng, Y, Han, P, Qi, J.X. | | 登録日 | 2024-03-22 | | 公開日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Discovery, Biological Activity, and Structural Mechanism of a Potent Inhibitor of SARS-CoV-2 Main Protease
To Be Published
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6GXR
 | | Crystal structure of BP39L lectin from Burkholderia pseudomallei at 1.7 A resolution | | 分子名称: | BP39L lectin, SULFATE ION | | 著者 | Sykorova, P, Novotna, J, Demo, G, Pompidor, G, Dubska, E, Komarek, J, Fujdiarova, E, Haronikova, L, Varrot, A, Imberty, A, Shilova, N, Bovin, N, Pokorna, M, Wimmerova, M. | | 登録日 | 2018-06-27 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold.
Int.J.Biol.Macromol., 152, 2020
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6UWU
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0516 | | 分子名称: | 1,2-ETHANEDIOL, 2-{4-[(2R)-2-hydroxy-3-(4-methylpiperazin-1-yl)propoxy]-3,5-dimethylphenyl}-5,7-dimethoxy-4H-1-benzopyran-4-one, Bromodomain-containing protein 4 | | 著者 | Leonard, P.G, Joseph, S. | | 登録日 | 2019-11-05 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation.
J.Med.Chem., 63, 2020
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6SKM
 | | Structure of the native full-length HIV-1 capsid protein A92E in helical assembly (-13,12) | | 分子名称: | Gag protein | | 著者 | Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P. | | 登録日 | 2019-08-16 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
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6SLQ
 | | Structure of the native full-length HIV-1 capsid protein A92E in helical assembly (-12,11) | | 分子名称: | Gag protein | | 著者 | Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P. | | 登録日 | 2019-08-20 | | 公開日 | 2020-09-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
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6SLU
 | | Structure of the native full-length HIV-1 capsid protein A92E in helical assembly (-13,11) | | 分子名称: | Gag protein | | 著者 | Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P. | | 登録日 | 2019-08-20 | | 公開日 | 2020-09-09 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
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6GXS
 | | Crystal structure of CV39L lectin from Chromobacterium violaceum at 1.8 A resolution | | 分子名称: | 1,2-ETHANEDIOL, CV39L lectin, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Sykorova, P, Novotna, J, Demo, G, Pompidor, G, Dubska, E, Komarek, J, Fujdiarova, E, Haronikova, L, Varrot, A, Imberty, A, Shilova, N, Bovin, N, Pokorna, M, Wimmerova, M. | | 登録日 | 2018-06-27 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold.
Int.J.Biol.Macromol., 152, 2020
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6SMU
 | | Structure of the native full-length HIV-1 capsid protein in helical assembly (-13,12) | | 分子名称: | Gag protein | | 著者 | Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P. | | 登録日 | 2019-08-22 | | 公開日 | 2020-09-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
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5WXC
 | | Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 2) | | 分子名称: | Beta-2-microglobulin, H7-25-F, HLA class I histocompatibility antigen, ... | | 著者 | Zhao, M, Liu, K, Chai, Y, Qi, J, Liu, J, Gao, G.F. | | 登録日 | 2017-01-07 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | | 主引用文献 | Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses.
Mbio, 9, 2018
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5WXD
 | | Crystal Structure of HLA-A*2402 in complex with avian influenza A(H7N9) virus-derived peptide H7-25 (data set 1) | | 分子名称: | Beta-2-microglobulin, H7-25, HLA class I histocompatibility antigen, ... | | 著者 | Zhao, M, Liu, K, Chai, Y, Qi, J, Liu, J, Gao, G.F. | | 登録日 | 2017-01-07 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.295 Å) | | 主引用文献 | Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses.
Mbio, 9, 2018
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8G05
 | | Cryo-EM structure of an orphan GPCR-Gi protein signaling complex | | 分子名称: | 6-(octylamino)pyrimidine-2,4(3H,5H)-dione, CHOLESTEROL, G-protein coupled receptor 84, ... | | 著者 | Zhang, X, Wang, Y.J, Li, X, Liu, G.B, Gong, W.M, Zhang, C. | | 登録日 | 2023-01-31 | | 公開日 | 2023-11-01 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Pro-phagocytic function and structural basis of GPR84 signaling.
Nat Commun, 14, 2023
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6SKK
 | | Structure of the native full-length HIV-1 capsid protein in helical assembly (-13,8) | | 分子名称: | capsid protein | | 著者 | Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P. | | 登録日 | 2019-08-15 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
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6SKN
 | | Structure of the native full-length HIV-1 capsid protein in helical assembly (-13,8) | | 分子名称: | Gag protein | | 著者 | Ni, T, Gerard, S, Zhao, G, Ning, J, Zhang, P. | | 登録日 | 2019-08-16 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
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4HBM
 | | Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors | | 分子名称: | E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-2-oxopiperidin-3-yl}acetic acid | | 著者 | Huang, X. | | 登録日 | 2012-09-28 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Ordering of the N-terminus of human MDM2 by small molecule inhibitors.
J.Am.Chem.Soc., 134, 2012
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4JWR
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5Z0Q
 | | Crystal Structure of OvoB | | 分子名称: | Aminotransferase, class I and II, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Cai, Y.J, Huang, P, Wu, L, Zhou, J.H, Liu, P.H. | | 登録日 | 2017-12-20 | | 公開日 | 2018-11-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions.
Org. Lett., 20, 2018
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5WWU
 | | Crystal Structure of HLA-A*2402 in complex with 2009 pandemic influenza A(H1N1) virus and avian influenza A(H5N1) virus-derived peptide H1-25 | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-24 alpha chain, ... | | 著者 | Zhao, M, Liu, K, Chai, Y, Qi, J, Liu, J, Gao, G.F. | | 登録日 | 2017-01-05 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.794 Å) | | 主引用文献 | Heterosubtypic Protections against Human-Infecting Avian Influenza Viruses Correlate to Biased Cross-T-Cell Responses.
Mbio, 9, 2018
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