6TRO
 
 | | Crystal structure of the T-cell receptor GVY01 bound to HLA A2*01-GVYDGREHTV | | 分子名称: | Beta-2-microglobulin, MAGE-A4 peptide (amino acids 230-239), MHC class I antigen, ... | | 著者 | Coles, C.H, McMurran, C, Lloyd, A, Hibbert, L, Lupardus, P.J, Cole, D.K, Harper, S. | | 登録日 | 2019-12-19 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.
J.Biol.Chem., 295, 2020
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8B8Q
 | | Structure of mTMEM16F in lipid Nanodiscs in the presence of Ca2+ | | 分子名称: | Anoctamin-6, CALCIUM ION | | 著者 | Arndt, M, Alvadia, C, Straub, M.S, Clerico-Mosina, V, Paulino, C, Dutzler, R. | | 登録日 | 2022-10-04 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Structural basis for the activation of the lipid scramblase TMEM16F.
Nat Commun, 13, 2022
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6TUG
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6TUN
 | | Helicase domain complex | | 分子名称: | CDK-activating kinase assembly factor MAT1, CHLORIDE ION, General transcription and DNA repair factor IIH helicase subunit XPD | | 著者 | Sauer, F, Kisker, C. | | 登録日 | 2020-01-07 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | In TFIIH the Arch domain of XPD is mechanistically essential for transcription and DNA repair.
Nat Commun, 11, 2020
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6TRN
 | | Crystal structure of HLA A2*01-AVYDGREHTV | | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, MAGE-A4 peptide (amino acids 230-239) variant, ... | | 著者 | Coles, C.H, McMurran, C, Lloyd, A, Hibbert, L, Lupardus, P.J, Cole, D.K, Harper, S. | | 登録日 | 2019-12-19 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4.
J.Biol.Chem., 295, 2020
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8BCQ
 | | N-terminal domain of Plasmodium berghei glutamyl-tRNA synthetase (native crystal structure) | | 分子名称: | GLYCEROL, Glutamate--tRNA ligase, SULFATE ION | | 著者 | Benas, P, Jaramillo Ponce, J.R, Frugier, M, Sauter, C. | | 登録日 | 2022-10-17 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Solution X-ray scattering highlights discrepancies in Plasmodium multi-aminoacyl-tRNA synthetase complexes.
Protein Sci., 32, 2023
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2V9T
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8ZEN
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9JMD
 | | Cryo-EM structure of the Azithromycin-Motilin receptor-Gq protein complex | | 分子名称: | AZITHROMYCIN, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, H.E, You, C, Jiang, Y. | | 登録日 | 2024-09-20 | | 公開日 | 2025-05-28 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | Decoding the structural basis of ligand recognition and biased signaling in the motilin receptor.
Cell Rep, 44, 2025
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8ZEP
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8ZEO
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8ZD8
 | | NMR structure of the (CGG-dsDNA:ND=) 1:1 complex | | 分子名称: | DNA (5'-D(*CP*AP*TP*TP*CP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(*CP*TP*AP*AP*CP*GP*GP*AP*AP*TP*G)-3'), ~{N}-(7-methyl-1,8-naphthyridin-2-yl)-3-[[3-[(7-methyl-1,8-naphthyridin-2-yl)amino]-3-oxidanylidene-propyl]amino]propanamide | | 著者 | Sakurabayashi, S, Furuita, K, Yamada, T, Nomura, M, Nakatani, K, Kojima, C. | | 登録日 | 2024-05-01 | | 公開日 | 2025-04-30 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of the (CGG-dsDNA:ND=) 1:1 complex
To Be Published
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8ZD7
 | | NMR structure of the CGG-dsDNA-sND complex | | 分子名称: | DNA (5'-D(*CP*AP*TP*TP*CP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(*CP*TP*AP*AP*CP*GP*GP*AP*AP*TP*G)-3'), ~{N}-(7-methyl-1,8-naphthyridin-2-yl)-2-[[2-[(7-methyl-1,8-naphthyridin-2-yl)amino]-2-oxidanylidene-ethyl]amino]ethanamide | | 著者 | Sakurabayashi, S, Furuita, K, Yamada, T, Nomura, M, Nakatani, K, Kojima, C. | | 登録日 | 2024-05-01 | | 公開日 | 2025-04-30 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of the CGG-dsDNA-sND complex
To Be Published
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2VC7
 | | Structural basis for natural lactonase and promiscuous phosphotriesterase activities | | 分子名称: | (4S)-4-(decanoylamino)-5-hydroxy-3,4-dihydro-2H-thiophenium, 1,2-ETHANEDIOL, ARYLDIALKYLPHOSPHATASE, ... | | 著者 | Elias, M, Dupuy, J, Merone, L, Mandrich, L, Moniot, S, Rochu, D, Lecomte, C, Rossi, M, Masson, P, Manco, G, Chabriere, E. | | 登録日 | 2007-09-19 | | 公開日 | 2008-04-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural Basis for Natural Lactonase and Promiscuous Phosphotriesterase Activities.
J.Mol.Biol., 379, 2008
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8ZD2
 | | NMR structure of the (CGG-dsDNA:ND=) 1:2 complex | | 分子名称: | DNA (5'-D(*CP*AP*TP*TP*CP*GP*GP*TP*TP*AP*G)-3'), DNA (5'-D(*CP*TP*AP*AP*CP*GP*GP*AP*AP*TP*G)-3'), ~{N}-(7-methyl-1,8-naphthyridin-2-yl)-3-[[3-[(7-methyl-1,8-naphthyridin-2-yl)amino]-3-oxidanylidene-propyl]amino]propanamide | | 著者 | Sakurabayashi, S, Furuita, K, Yamada, T, Nomura, M, Nakatani, K, Kojima, C. | | 登録日 | 2024-05-01 | | 公開日 | 2025-04-30 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of the (CGG-dsDNA:ND=) 1:2 complex
To Be Published
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2VGB
 | | HUMAN ERYTHROCYTE PYRUVATE KINASE | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Valentini, G, Chiarelli, L, Fortin, R, Dolzan, M, Galizzi, A, Abraham, D.J, Wang, C, Bianchi, P, Zanella, A, Mattevi, A. | | 登録日 | 2007-11-12 | | 公開日 | 2007-11-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | Structure and Function of Human Erythrocyte Pyruvate Kinase. Molecular Basis of Nonspherocytic Hemolytic Anemia.
J.Biol.Chem., 277, 2002
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7EVJ
 | | Crystal structure of CBP bromodomain liganded with 9c | | 分子名称: | 3-acetyl-1-((3-(1-cyclopropyl-1H-pyrazol-4-yl)-2-fluoro-5-(hydroxymethyl)phenyl)carbamoyl)indolizin-7-yl dimethylcarbamate, CREB-binding protein, GLYCEROL, ... | | 著者 | Xiang, Q, Wang, C, Wu, T, Zhang, Y, Zhang, C, Luo, G, Wu, X, Shen, H, Xu, Y. | | 登録日 | 2021-05-21 | | 公開日 | 2022-02-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.
J.Med.Chem., 65, 2022
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7FIO
 | | LecA from Pseudomonas aeruginosa in complex with a synthetic monovalent galactosidic inhibitor | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, N-[2-[4-[(2S)-3-(2-hydroxyethylamino)-3-oxidanylidene-2-(2-phenoxyethanoylamino)propyl]-1,2,3-triazol-1-yl]ethyl]-4-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]sulfanyl-benzamide, ... | | 著者 | Kuhaudomlarp, S, Siebs, E, da Silva Figueiredo Celestino Gomes, P, Fortin, C, Rognan, D, Rademacher, C, Imberty, A, Titz, A. | | 登録日 | 2021-07-31 | | 公開日 | 2022-02-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA.
Chembiochem, 23, 2022
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8ZMP
 | | Cryo-EM structure of the spike glycoprotein from Bat SARS-like coronavirus (Bat SL-CoV) WIV1 in locked state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | | 著者 | Liu, C, Beck, F, Nagy, I, Bohn, S, Plitzko, J, Baumeister, W, Zhang, X, Zinzula, L. | | 登録日 | 2024-05-23 | | 公開日 | 2025-05-28 | | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | | 主引用文献 | Cryo-EM structure of the spike glycoprotein from Bat SARS-like coronavirus WIV1
To Be Published
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4U7D
 | | Structure of human RECQ-like helicase in complex with an oligonucleotide | | 分子名称: | ATP-dependent DNA helicase Q1, DNA oligonucleotide, ZINC ION | | 著者 | Pike, A.C.W, Zhang, Y, Schnecke, C, Cooper, C.D.O, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O, Structural Genomics Consortium (SGC) | | 登録日 | 2014-07-30 | | 公開日 | 2015-01-21 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures.
Proc.Natl.Acad.Sci.USA, 112, 2015
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8ZW0
 | | Cryo-EM strcuture of Prostaglandin D2 Receptor DP1 activated by PGD2 | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, J, Xu, Y, Wu, C, Xu, H.E. | | 登録日 | 2024-06-12 | | 公開日 | 2025-05-28 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (2.72 Å) | | 主引用文献 | Molecular basis for ligand recognition and receptor activation of the prostaglandin D2 receptor DP1.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8ZST
 | | Lysozyme Crystallized with Bioassembler on Earth | | 分子名称: | 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, CHLORIDE ION, GADOLINIUM ATOM, ... | | 著者 | MacCarthy, C, Koudan, E.V, Petrov, S.V, Levin, A.A, Khesuani, Y.D, Borshchevskiy, V. | | 登録日 | 2024-06-05 | | 公開日 | 2025-05-28 | | 最終更新日 | 2025-06-25 | | 実験手法 | X-RAY DIFFRACTION (0.8 Å) | | 主引用文献 | Exploring the potential of a bioassembler for protein crystallization in space.
Npj Microgravity, 11, 2025
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8ZVZ
 | | Cryo-EM strcuture of Prostaglandin D2 Receptor DP1 activated by BW245C | | 分子名称: | 7-{(4S)-3-[(3R)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxoimidazolidin-4-yl}heptanoic acid, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, J, Xu, Y, Wu, C, Xu, H.E. | | 登録日 | 2024-06-12 | | 公開日 | 2025-05-28 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (2.35 Å) | | 主引用文献 | Molecular basis for ligand recognition and receptor activation of the prostaglandin D2 receptor DP1.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8ZSU
 | | Lysozyme Crystallized with Bioassembler in Space Microgravity | | 分子名称: | 10-((2R)-2-HYDROXYPROPYL)-1,4,7,10-TETRAAZACYCLODODECANE 1,4,7-TRIACETIC ACID, CHLORIDE ION, GADOLINIUM ATOM, ... | | 著者 | MacCarthy, C, Koudan, E.V, Petrov, S.V, Levin, A.A, Khesuani, Y.D, Borshchevskiy, V. | | 登録日 | 2024-06-05 | | 公開日 | 2025-05-28 | | 最終更新日 | 2025-06-25 | | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | | 主引用文献 | Exploring the potential of a bioassembler for protein crystallization in space.
Npj Microgravity, 11, 2025
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2V22
 | | REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors | | 分子名称: | CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, N~2~-{[1-(4-CHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOL-3-YL]CARBONYL}-N~5~-(DIAMINOMETHYLIDENE)-L-ORNITHYL-L-LEUCYL-L-ISOLEUCYL-4-FLUORO-L-PHENYLALANINAMIDE | | 著者 | Andrews, M.J, Kontopidis, G, McInnes, C, Plater, A, Innes, L, Cowan, A, Jewsbury, P, Fischer, P.M. | | 登録日 | 2007-05-31 | | 公開日 | 2008-01-29 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors
Chembiochem, 7, 2006
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