7V6Z
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![BU of 7v6z by Molmil](/molmil-images/mine/7v6z) | Cryo-EM structure of Patched1 (V1084A mutant) in lipid nanodisc, 3.64 angstrom (reprocessed with the dataset of 7dzp) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Luo, Y, Zhao, Y, Qu, Q, Li, D. | 登録日 | 2021-08-20 | 公開日 | 2021-09-22 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae. Structure, 29, 2021
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2Q58
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![BU of 2q58 by Molmil](/molmil-images/mine/2q58) | Cryptosporidium parvum putative polyprenyl pyrophosphate synthase (cgd4_2550) in complex with zoledronate | 分子名称: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, ZOLEDRONIC ACID | 著者 | Chruszcz, M, Artz, J, Zheng, H, Dong, A, Dunford, J, Lew, J, Zhao, Y, Kozieradski, I, Kavanaugh, K.L, Opperman, U, Sundstrom, M, Weigelt, J, Edwards, A, Arrowsmith, C, Bochkarev, A, Hui, R, Minor, W, Structural Genomics Consortium (SGC) | 登録日 | 2007-05-31 | 公開日 | 2007-06-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis Chem.Biol., 15, 2008
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5XGI
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![BU of 5xgi by Molmil](/molmil-images/mine/5xgi) | Crystal structure of PI3K complex with an inhibitor | 分子名称: | 3-azanyl-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol, GLYCEROL, HEXAETHYLENE GLYCOL, ... | 著者 | Song, K, Yang, X, Zhao, Y, Jian, Z. | 登録日 | 2017-04-13 | 公開日 | 2018-04-25 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Crystal structure of PI3K complex with an inhibitor To Be Published
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5Z1Q
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![BU of 5z1q by Molmil](/molmil-images/mine/5z1q) | Crystal structures of the trimeric N-terminal domain of Ciliate Euplotes octocarinatus Centrin | 分子名称: | CALCIUM ION, CHLORIDE ION, Centrin protein | 著者 | Wang, W, Zhao, Y, Yang, B, Wang, H. | 登録日 | 2017-12-27 | 公開日 | 2018-04-25 | 最終更新日 | 2018-06-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the trimeric N-terminal domain of ciliate Euplotes octocarinatus centrin binding with calcium ions Protein Sci., 27, 2018
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5Z87
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![BU of 5z87 by Molmil](/molmil-images/mine/5z87) | Structural of a novel b-glucosidase EmGH1 at 2.3 angstrom from Erythrobacter marinus | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BENZAMIDINE, ... | 著者 | Li, J.X, Hu, X.J, Zhao, Y, Li, L. | 登録日 | 2018-01-31 | 公開日 | 2019-02-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and biochemical analysis of a novel b-glucosidase EmGH1 from Erythrobacter marinus To Be Published
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5XGJ
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![BU of 5xgj by Molmil](/molmil-images/mine/5xgj) | Crystal structure of PI3K complex with an inhibitor | 分子名称: | 3-(4-morpholin-4-ylfuro[3,2-d]pyrimidin-2-yl)-5-[(phenylmethyl)amino]phenol, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | 著者 | Song, K, Yang, X, Zhao, Y, Jian, Z. | 登録日 | 2017-04-13 | 公開日 | 2018-04-25 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Crystal structure of PI3K complex with an inhibitor To Be Published
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7CNU
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8HLP
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![BU of 8hlp by Molmil](/molmil-images/mine/8hlp) | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 (apo) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Wei, Y, Yu, Z, Zhao, Y. | 登録日 | 2022-11-30 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nat Commun, 15, 2024
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8HMB
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![BU of 8hmb by Molmil](/molmil-images/mine/8hmb) | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with benidipine (BEN) | 分子名称: | (3R)-1-benzylpiperidin-3-yl methyl (2R,3R,4R,5R,6S)-2,6-dimethyl-4-(3-nitrophenyl)piperidine-3,5-dicarboxylate, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wei, Y, Yu, Z, Zhao, Y. | 登録日 | 2022-12-02 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nat Commun, 15, 2024
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8HMA
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![BU of 8hma by Molmil](/molmil-images/mine/8hma) | Cryo-EM structure of human high-voltage activated L-type calcium channel CaV1.2 in complex with tetrandrine (TET) | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6,6',7,12-tetramethoxy-2,2'-dimethyl-1beta-3,4-didehydroberbaman, ... | 著者 | Wei, Y, Yu, Z, Zhao, Y. | 登録日 | 2022-12-02 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural bases of inhibitory mechanism of Ca V 1.2 channel inhibitors. Nat Commun, 15, 2024
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8HYA
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8H1D
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![BU of 8h1d by Molmil](/molmil-images/mine/8h1d) | Solid-state NMR Structure of Aquaporin Z in its Native Cellular Membranes | 分子名称: | Aquaporin Z | 著者 | Xie, H, Zhao, Y, Zhao, W, Chen, Y, Liu, M, Yang, J. | 登録日 | 2022-10-02 | 公開日 | 2022-11-09 | 最終更新日 | 2024-05-15 | 実験手法 | SOLID-STATE NMR | 主引用文献 | Solid-state NMR structure determination of a membrane protein in E. coli cellular inner membrane. Sci Adv, 9, 2023
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7WF3
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![BU of 7wf3 by Molmil](/molmil-images/mine/7wf3) | Composite map of human Kv1.3 channel in apo state with beta subunits | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 3, ... | 著者 | Tyagi, A, Ahmed, T, Jian, S, Bajaj, S, Ong, S.T, Goay, S.S.M, Zhao, Y, Vorobyov, I, Tian, C, Chandy, K.G, Bhushan, S. | 登録日 | 2021-12-25 | 公開日 | 2022-02-09 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WF4
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![BU of 7wf4 by Molmil](/molmil-images/mine/7wf4) | Composite map of human Kv1.3 channel in dalazatide-bound state with beta subunits | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 3, ... | 著者 | Tyagi, A, Ahmed, T, Jian, S, Bajaj, S, Ong, S.T, Goay, S.S.M, Zhao, Y, Vorobyov, I, Tian, C, Chandy, K.G, Bhushan, S. | 登録日 | 2021-12-25 | 公開日 | 2022-02-09 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. Proc.Natl.Acad.Sci.USA, 119, 2022
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8JP0
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![BU of 8jp0 by Molmil](/molmil-images/mine/8jp0) | structure of human sodium-calciumexchanger NCX1 | 分子名称: | 2-{4-[(2,5-difluorophenyl)methoxy]phenoxy}-5-ethoxyaniline, Sodium/calcium exchanger 1 | 著者 | Dong, Y, Zhao, Y. | 登録日 | 2023-06-09 | 公開日 | 2024-01-03 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400. Embo J., 43, 2024
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8J77
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8J75
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![BU of 8j75 by Molmil](/molmil-images/mine/8j75) | Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, monomeric state | 分子名称: | (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium), High affinity choline transporter 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Gao, Y, Qiu, Y, Zhao, Y. | 登録日 | 2023-04-27 | 公開日 | 2024-04-10 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Transport mechanism of presynaptic high-affinity choline uptake by CHT1. Nat.Struct.Mol.Biol., 31, 2024
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8J76
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8J74
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![BU of 8j74 by Molmil](/molmil-images/mine/8j74) | Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, dimeric state | 分子名称: | (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium), CHOLESTEROL HEMISUCCINATE, HEXADECANE, ... | 著者 | Gao, Y, Qiu, Y, Zhao, Y. | 登録日 | 2023-04-27 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Transport mechanism of presynaptic high-affinity choline uptake by CHT1. Nat.Struct.Mol.Biol., 31, 2024
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7WU7
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![BU of 7wu7 by Molmil](/molmil-images/mine/7wu7) | Prefoldin-tubulin-TRiC complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Prefoldin subunit 1, Prefoldin subunit 2, ... | 著者 | Gestaut, D, Zhao, Y, Park, J, Ma, B, Leitner, A, Collier, M, Pintilie, G, Roh, S.-H, Chiu, W, Frydman, J. | 登録日 | 2022-02-07 | 公開日 | 2022-12-21 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | 主引用文献 | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT. Cell, 185, 2022
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8HLG
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![BU of 8hlg by Molmil](/molmil-images/mine/8hlg) | Crystal structure of MoaE | 分子名称: | Molybdenum cofactor biosynthesis protein D/E, SULFATE ION | 著者 | Cai, J, Zhao, Y. | 登録日 | 2022-11-30 | 公開日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | MoaE Is Involved in Response to Oxidative Stress in Deinococcus radiodurans. Int J Mol Sci, 24, 2023
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7COC
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7CO8
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![BU of 7co8 by Molmil](/molmil-images/mine/7co8) | Ternary complex of DNA polymerase Mu with 2-nt gapped DNA (T:dGMPNPP) | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-D(*CP*GP*GP*CP*TP*TP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), ... | 著者 | Guo, M, Zhao, Y. | 登録日 | 2020-08-04 | 公開日 | 2021-06-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.697 Å) | 主引用文献 | Mechanism of genome instability mediated by human DNA polymerase mu misincorporation. Nat Commun, 12, 2021
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7COB
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7COD
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![BU of 7cod by Molmil](/molmil-images/mine/7cod) | |