7WF4

Composite map of human Kv1.3 channel in dalazatide-bound state with beta subunits

Summary for 7WF4

Entry DOI	10.2210/pdb7wf4/pdb
EMDB information	32460
Descriptor	Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit beta-2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywords	ion channel, kv channel, potassium channel, peptide toxin, shk, dalazatide, selectivity filter, molecular dynamics simulation, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	326859.70
Authors	Tyagi, A.,Ahmed, T.,Jian, S.,Bajaj, S.,Ong, S.T.,Goay, S.S.M.,Zhao, Y.,Vorobyov, I.,Tian, C.,Chandy, K.G.,Bhushan, S. (deposition date: 2021-12-25, release date: 2022-02-09, Last modification date: 2022-05-25)
Primary citation	Tyagi, A.,Ahmed, T.,Jian, S.,Bajaj, S.,Ong, S.T.,Goay, S.S.M.,Zhao, Y.,Vorobyov, I.,Tian, C.,Chandy, K.G.,Bhushan, S. Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug. Proc.Natl.Acad.Sci.USA, 119:-, 2022 Cited by PubMed: 35091471 DOI: 10.1073/pnas.2113536119 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation