8J77

Human high-affinity choline transporter CHT1 in the choline-bound inward-facing occluded conformation

Summary for 8J77

Entry DOI	10.2210/pdb8j77/pdb
EMDB information	36030
Descriptor	High affinity choline transporter 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLINE ION (3 entities in total)
Functional Keywords	cht1, slc5a7, high affinity choline transporter, choline transporter, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	63929.86
Authors	Gao, Y.,Qiu, Y.,Zhao, Y. (deposition date: 2023-04-27, release date: 2024-04-10, Last modification date: 2024-05-01)
Primary citation	Qiu, Y.,Gao, Y.,Huang, B.,Bai, Q.,Zhao, Y. Transport mechanism of presynaptic high-affinity choline uptake by CHT1. Nat.Struct.Mol.Biol., 31:701-709, 2024 Cited by PubMed: 38589607 DOI: 10.1038/s41594-024-01259-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation