8PN9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pn9 by Molmil](/molmil-images/mine/8pn9) | Structure of human oligosaccharyltransferase OST-A complex bound to NGI-1 | 分子名称: | (2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAENYL TRIHYDROGEN DIPHOSPHATE, (2~{S},3~{R},4~{R},5~{S},6~{S})-2-(hydroxymethyl)-6-[(1~{S},2~{R},3~{R},4~{R},5'~{S},6~{S},7~{R},8~{S},9~{R},12~{R},13~{R},15~{S},16~{S},18~{R})-5',7,9,13-tetramethyl-3,15-bis(oxidanyl)spiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-16-yl]oxy-oxane-3,4,5-triol, (4R,7R)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(undecanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphadocosan-1-aminium, ... | 著者 | Ramirez, A.S, Kowal, J, Locher, K.P. | 登録日 | 2023-06-30 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappa B. Cell, 187, 2024
|
|
2HEP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2hep by Molmil](/molmil-images/mine/2hep) | Solution NMR structure of the UPF0291 protein ynzC from Bacillus subtilis. Northeast Structural Genomics target SR384. | 分子名称: | UPF0291 protein ynzC | 著者 | Aramini, J.M, Swapna, G.V.T, Ho, C.K, Shetty, K, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M, Acton, T.B, Rost, B, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-06-21 | 公開日 | 2006-08-15 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR structure of the SOS response protein YnzC from Bacillus subtilis Proteins, 72, 2008
|
|
2INW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2inw by Molmil](/molmil-images/mine/2inw) | Crystal structure of Q83JN9 from Shigella flexneri at high resolution. Northeast Structural Genomics Consortium target SfR137. | 分子名称: | PHOSPHATE ION, Putative structural protein | 著者 | Kuzin, A.P, Su, M, Jayaraman, S, Vorobiev, S.M, Wang, D, Jiang, M, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2006-10-09 | 公開日 | 2006-10-24 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal Structures of Phd-Doc, HigA, and YeeU Establish Multiple Evolutionary Links between Microbial Growth-Regulating Toxin-Antitoxin Systems. Structure, 18, 2010
|
|
6J8F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j8f by Molmil](/molmil-images/mine/6j8f) | Crystal structure of SVBP-VASH1 with peptide mimic the C-terminal of alpha-tubulin | 分子名称: | 8-mer peptide, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | 著者 | Liao, S, Gao, J, Xu, C, Structural Genomics Consortium (SGC) | 登録日 | 2019-01-18 | 公開日 | 2019-06-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.283 Å) | 主引用文献 | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
|
|
6J8N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j8n by Molmil](/molmil-images/mine/6j8n) | Crystal structure of SVBP-VASH1 complex, mutation C169A of VASH1 | 分子名称: | Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | 著者 | Liao, S, Gao, J, Xu, C, Structural Genomics Consortium (SGC) | 登録日 | 2019-01-20 | 公開日 | 2019-06-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
|
|
6J9H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j9h by Molmil](/molmil-images/mine/6j9h) | |
4BY5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4by5 by Molmil](/molmil-images/mine/4by5) | |
6J7B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j7b by Molmil](/molmil-images/mine/6j7b) | Crystal structure of VASH1-SVBP in complex with epoY | 分子名称: | N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-tyrosine, Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | 著者 | Wang, N, Bao, H, Huang, H, Wu, B. | 登録日 | 2019-01-17 | 公開日 | 2019-06-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.618 Å) | 主引用文献 | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
|
|
6J91
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j91 by Molmil](/molmil-images/mine/6j91) | Structure of a hypothetical protease | 分子名称: | Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | 著者 | Liao, S, Gao, J, Xu, C. | 登録日 | 2019-01-21 | 公開日 | 2019-06-19 | 最終更新日 | 2019-07-17 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res., 29, 2019
|
|
4BY4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4by4 by Molmil](/molmil-images/mine/4by4) | |
5M37
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5m37 by Molmil](/molmil-images/mine/5m37) | The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | 分子名称: | (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... | 著者 | Bier, D, Ottmann, C. | 登録日 | 2016-10-14 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
|
|
5OEG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5oeg by Molmil](/molmil-images/mine/5oeg) | Molecular tweezers modulate 14-3-3 protein-protein interactions | 分子名称: | (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein sigma, CHLORIDE ION | 著者 | Bier, D, Ottmann, C. | 登録日 | 2017-07-07 | 公開日 | 2017-07-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Molecular tweezers modulate 14-3-3 protein-protein interactions. Nat Chem, 5, 2013
|
|
5M36
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5m36 by Molmil](/molmil-images/mine/5m36) | The molecular tweezer CLR01 stabilizes a disordered protein-protein interface | 分子名称: | (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... | 著者 | Bier, D, Ottmann, C. | 登録日 | 2016-10-14 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
|
|
4Q9S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q9s by Molmil](/molmil-images/mine/4q9s) | Crystal Structure of human Focal Adhesion Kinase (Fak) bound to Compound1 (3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE) | 分子名称: | 3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one, Focal adhesion kinase 1 | 著者 | Argiriadi, M.A, George, D.M. | 登録日 | 2014-05-01 | 公開日 | 2014-07-02 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Discovery of Selective and Orally Bioavailable Protein Kinase C theta (PKC theta ) Inhibitors from a Fragment Hit. J.Med.Chem., 58, 2015
|
|
5OEH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5oeh by Molmil](/molmil-images/mine/5oeh) | Molecular tweezers modulate 14-3-3 protein-protein interactions. | 分子名称: | (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein sigma, CHLORIDE ION, ... | 著者 | Bier, D, Ottmann, C. | 登録日 | 2017-07-07 | 公開日 | 2017-07-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Molecular tweezers modulate 14-3-3 protein-protein interactions. Nat Chem, 5, 2013
|
|
4Q9Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q9z by Molmil](/molmil-images/mine/4q9z) | Human Protein Kinase C Theta in Complex with Compound35 ((1R)-9-(AZETIDIN-3-YLAMINO)-1,8-DIMETHYL-3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE) | 分子名称: | (1R)-9-(azetidin-3-ylamino)-1,8-dimethyl-3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one, HUMAN PROTEIN KINASE C THETA, SODIUM ION | 著者 | Argiriadi, M.A, George, D.M. | 登録日 | 2014-05-02 | 公開日 | 2014-07-02 | 最終更新日 | 2015-01-21 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of Selective and Orally Bioavailable Protein Kinase C theta (PKC theta ) Inhibitors from a Fragment Hit. J.Med.Chem., 58, 2015
|
|
4QT1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qt1 by Molmil](/molmil-images/mine/4qt1) | |
5HT6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ht6 by Molmil](/molmil-images/mine/5ht6) | Crystal structure of the SET domain of the human MLL5 methyltransferase | 分子名称: | Histone-lysine N-methyltransferase 2E | 著者 | le Maire, A, Mas-y-Mas, S, Dumas, C, Lebedev, A. | 登録日 | 2016-01-26 | 公開日 | 2016-11-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.093 Å) | 主引用文献 | The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity. Plos One, 11, 2016
|
|
2Q3X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2q3x by Molmil](/molmil-images/mine/2q3x) | The RIM1alpha C2B domain | 分子名称: | CHLORIDE ION, Regulating synaptic membrane exocytosis protein 1, SODIUM ION, ... | 著者 | Guan, R, Dai, H, Tomchick, D.R, Machius, M, Sudhof, T.C, Rizo, J. | 登録日 | 2007-05-30 | 公開日 | 2007-08-28 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Crystal Structure of the RIM1alpha C(2)B Domain at 1.7 A Resolution. Biochemistry, 46, 2007
|
|
1P5T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1p5t by Molmil](/molmil-images/mine/1p5t) | Crystal Structure of Dok1 PTB Domain | 分子名称: | Docking protein 1 | 著者 | Shi, N, Ye, S, Liu, Y, Zhou, W, Ding, Y, Lou, Z, Qiang, B, Yuan, J, Rao, Z. | 登録日 | 2003-04-28 | 公開日 | 2004-02-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural Basis for the Specific Recognition of RET by the Dok1 Phosphotyrosine Binding Domain J.BIOL.CHEM., 279, 2004
|
|
6NPF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6npf by Molmil](/molmil-images/mine/6npf) | Structure of E.coli enolase in complex with an analog of the natural product SF-2312 metabolite. | 分子名称: | Enolase, GLYCEROL, L(+)-TARTARIC ACID, ... | 著者 | Erlandsen, H, Krucinska, J, Lombardo, M, Wright, D. | 登録日 | 2019-01-17 | 公開日 | 2019-11-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate. Sci Rep, 9, 2019
|
|
4XZP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4xzp by Molmil](/molmil-images/mine/4xzp) | |
4C66
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4c66 by Molmil](/molmil-images/mine/4c66) | Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains | 分子名称: | 4-(2-chlorophenyl)-2-ethyl-9-methyl-6,8-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Chung, C, Mirguet, O. | 登録日 | 2013-09-17 | 公開日 | 2013-10-02 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Discovery of Epigenetic Regulator I-Bet762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the Bet Bromodomains. J.Med.Chem., 56, 2013
|
|
3CTZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ctz by Molmil](/molmil-images/mine/3ctz) | Structure of human cytosolic X-prolyl aminopeptidase | 分子名称: | CALCIUM ION, HEXAETHYLENE GLYCOL, MANGANESE (II) ION, ... | 著者 | Li, X, Lou, Z, Rao, Z. | 登録日 | 2008-04-15 | 公開日 | 2008-05-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit J.Biol.Chem., 283, 2008
|
|
3HW4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hw4 by Molmil](/molmil-images/mine/3hw4) | Crystal structure of avian influenza A virus in complex with TMP | 分子名称: | MAGNESIUM ION, Polymerase acidic protein, THYMIDINE-5'-PHOSPHATE | 著者 | Zhao, C, Lou, Z, Guo, Y, Ma, M, Chen, Y, Rao, Z. | 登録日 | 2009-06-17 | 公開日 | 2009-11-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center J.Virol., 83, 2009
|
|