4Q9S
Crystal Structure of human Focal Adhesion Kinase (Fak) bound to Compound1 (3,5-DIHYDRO[1,2,4]TRIAZINO[3,4-C][1,4]BENZOXAZIN-2(1H)-ONE)
Summary for 4Q9S
Entry DOI | 10.2210/pdb4q9s/pdb |
Related | 4Q9Z |
Descriptor | Focal adhesion kinase 1, 3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one (3 entities in total) |
Functional Keywords | kinase catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell junction, focal adhesion: Q05397 |
Total number of polymer chains | 1 |
Total formula weight | 32323.34 |
Authors | Argiriadi, M.A.,George, D.M. (deposition date: 2014-05-01, release date: 2014-07-02, Last modification date: 2024-10-16) |
Primary citation | George, D.M.,Breinlinger, E.C.,Friedman, M.,Zhang, Y.,Wang, J.,Argiriadi, M.,Bansal-Pakala, P.,Barth, M.,Duignan, D.B.,Honore, P.,Lang, Q.,Mittelstadt, S.,Potin, D.,Rundell, L.,Edmunds, J.J. Discovery of Selective and Orally Bioavailable Protein Kinase C theta (PKC theta ) Inhibitors from a Fragment Hit. J.Med.Chem., 58:222-236, 2015 Cited by PubMed: 25000588DOI: 10.1021/jm500669m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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