7RT4
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![BU of 7rt4 by Molmil](/molmil-images/mine/7rt4) | KRAS G12D in complex with Compound 5B (7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-4-(piperazin-1-yl)pyrido[4,3-d]pyrimidine) | 分子名称: | 7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-4-(piperazin-1-yl)pyrido[4,3-d]pyrimidine, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Gunn, R.J, Thomas, N.C, Xiaolun, W, Lawson, J.D, Marx, M.A. | 登録日 | 2021-08-12 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor. J.Med.Chem., 65, 2022
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7RPZ
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![BU of 7rpz by Molmil](/molmil-images/mine/7rpz) | KRAS G12D in complex with MRTX-1133 | 分子名称: | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | 著者 | Gunn, R.J, Thomas, N.C, Xiaolun, W, Lawson, J.D, Marx, M.A. | 登録日 | 2021-08-05 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor. J.Med.Chem., 65, 2022
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7RT3
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![BU of 7rt3 by Molmil](/molmil-images/mine/7rt3) | Crystal Structure of KRAS G12D with compound 24 (4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2S,4S,7aR)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol) bound | 分子名称: | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2S,4S,7aR)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | 著者 | Gunn, R.J, Thomas, N.C, Xiaolun, W, Lawson, J.D, Marx, M.A. | 登録日 | 2021-08-12 | 公開日 | 2021-12-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor. J.Med.Chem., 65, 2022
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5LN3
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![BU of 5ln3 by Molmil](/molmil-images/mine/5ln3) | The human 26S Proteasome at 6.8 Ang. | 分子名称: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | 著者 | Schweitzer, A, Beck, F, Sakata, E, Unverdorben, P. | 登録日 | 2016-08-03 | 公開日 | 2017-03-22 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Mol. Cell Proteomics, 16, 2017
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1DL0
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![BU of 1dl0 by Molmil](/molmil-images/mine/1dl0) | |
7YBL
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![BU of 7ybl by Molmil](/molmil-images/mine/7ybl) | SARS-CoV-2 B.1.620 variant spike (close state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, X, Fu, W. | 登録日 | 2022-06-29 | 公開日 | 2023-08-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants. Virol Sin, 37, 2022
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7YBK
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![BU of 7ybk by Molmil](/molmil-images/mine/7ybk) | SARS-CoV-2 B.1.620 variant spike (open state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, X, Fu, W. | 登録日 | 2022-06-29 | 公開日 | 2023-09-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants. Virol Sin, 37, 2022
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7YBH
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![BU of 7ybh by Molmil](/molmil-images/mine/7ybh) | SARS-CoV-2 lambda variant spike | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Wang, X, Fu, W. | 登録日 | 2022-06-29 | 公開日 | 2023-08-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants. Virol Sin, 37, 2022
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7YBM
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![BU of 7ybm by Molmil](/molmil-images/mine/7ybm) | SARS-CoV-2 C.1.2 variant spike (Close state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, X, Fu, W. | 登録日 | 2022-06-29 | 公開日 | 2023-08-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants. Virol Sin, 37, 2022
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6LPC
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![BU of 6lpc by Molmil](/molmil-images/mine/6lpc) | Crystal Structure of rat Munc18-1 with K332E/K333E mutation | 分子名称: | Syntaxin-binding protein 1 | 著者 | Wang, X.P, Gong, J.H, Wang, S, Zhu, L, Yang, X.Y, Xu, Y.Y, Yang, X.F, Ma, C. | 登録日 | 2020-01-09 | 公開日 | 2020-07-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.402 Å) | 主引用文献 | Munc13 activates the Munc18-1/syntaxin-1 complex and enables Munc18-1 to prime SNARE assembly. Embo J., 39, 2020
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7YNX
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![BU of 7ynx by Molmil](/molmil-images/mine/7ynx) | Crystal structure of Pirh2 bound to poly-Ala peptide | 分子名称: | RING finger and CHY zinc finger domain-containing protein 1, SODIUM ION, SULFATE ION, ... | 著者 | Dong, C, Yan, X, Li, Y. | 登録日 | 2022-08-01 | 公開日 | 2023-04-26 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Recognition of an Ala-rich C-degron by the E3 ligase Pirh2. Nat Commun, 14, 2023
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5ZVS
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5ZVT
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![BU of 5zvt by Molmil](/molmil-images/mine/5zvt) | Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly | 分子名称: | C-terminus of outer capsid protein VP5, Core protein VP6, MYRISTIC ACID, ... | 著者 | Liu, H, Fang, Q, Cheng, L. | 登録日 | 2018-05-12 | 公開日 | 2018-07-04 | 最終更新日 | 2018-07-25 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6AEO
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![BU of 6aeo by Molmil](/molmil-images/mine/6aeo) | TssL periplasmic domain | 分子名称: | GLYCEROL, Maltose/maltodextrin-binding periplasmic protein,TssL | 著者 | Ran, T.T, Wang, W.W, Wang, X.B, Xu, D.Q. | 登録日 | 2018-08-06 | 公開日 | 2019-06-12 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of the periplasmic domain of TssL, a key membrane component of Type VI secretion system. Int.J.Biol.Macromol., 120, 2018
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6A7W
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![BU of 6a7w by Molmil](/molmil-images/mine/6a7w) | Structure of a catalytic domain of the colistin resistance enzyme | 分子名称: | Putative integral membrane protein, ZINC ION | 著者 | Wang, X.D, Chai, Y, Qi, J.X, Gao, G.F. | 登録日 | 2018-07-04 | 公開日 | 2018-11-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.988 Å) | 主引用文献 | Structural and functional insights into MCR-2 mediated colistin resistance. Sci China Life Sci, 61, 2018
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8IN8
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![BU of 8in8 by Molmil](/molmil-images/mine/8in8) | Cryo-EM structure of the target ssDNA-bound SIR2-APAZ/Ago-gRNA quaternary complex | 分子名称: | DNA (5'-D(P*AP*AP*CP*GP*AP*CP*GP*TP*CP*TP*AP*AP*GP*AP*AP*AP*CP*CP*AP*TP*TP*AP*A)-3'), MAGNESIUM ION, Piwi domain protein, ... | 著者 | Zhang, H, Li, Z, Yu, G.M, Li, X.Z, Wang, X.S. | 登録日 | 2023-03-08 | 公開日 | 2023-07-05 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity. Cell Res., 33, 2023
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8I88
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![BU of 8i88 by Molmil](/molmil-images/mine/8i88) | Cryo-EM structure of TIR-APAZ/Ago-gRNA complex | 分子名称: | Piwi domain-containing protein, RNA (5'-R(P*GP*A)-3'), TIR domain-containing protein | 著者 | Zhang, H, Li, Z, Yu, G.M, Li, X.Z, Wang, X.S. | 登録日 | 2023-02-03 | 公開日 | 2023-07-05 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity. Cell Res., 33, 2023
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8I87
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![BU of 8i87 by Molmil](/molmil-images/mine/8i87) | Cryo-EM structure of TIR-APAZ/Ago-gRNA-DNA complex | 分子名称: | DNA (5'-D(P*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*A)-3'), MAGNESIUM ION, Piwi domain-containing protein, ... | 著者 | Zhang, H, Deng, Z.Q, Yu, G.M, Li, X.Z, Wang, X.S. | 登録日 | 2023-02-03 | 公開日 | 2023-07-19 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity. Cell Res., 33, 2023
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2GH0
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![BU of 2gh0 by Molmil](/molmil-images/mine/2gh0) | Growth factor/receptor complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GDNF family receptor alpha-3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wang, X.Q. | 登録日 | 2006-03-24 | 公開日 | 2006-06-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure, 14, 2006
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2GYR
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![BU of 2gyr by Molmil](/molmil-images/mine/2gyr) | Crystal structure of human artemin | 分子名称: | Neurotrophic factor artemin, isoform 3 | 著者 | Wang, X.Q. | 登録日 | 2006-05-09 | 公開日 | 2006-06-27 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure, 14, 2006
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2GYZ
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![BU of 2gyz by Molmil](/molmil-images/mine/2gyz) | Crystal structure of human artemin | 分子名称: | neurotrophic factor artemin isoform 3 | 著者 | Wang, X.Q, Garcia, K.C. | 登録日 | 2006-05-10 | 公開日 | 2006-06-27 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure, 14, 2006
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8IM7
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![BU of 8im7 by Molmil](/molmil-images/mine/8im7) | Human gamma-secretase treated with ganglioside GM1 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhou, R, Yang, G, Shi, Y. | 登録日 | 2023-03-06 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Preferential Regulation of Gamma-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease. Adv Sci, 10, 2023
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5V82
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![BU of 5v82 by Molmil](/molmil-images/mine/5v82) | PIM1 kinase in complex with Cpd17 (1-(6-(4,4-difluoropiperidin-3-yl)pyridin-2-yl)-6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine) | 分子名称: | 1-{6-[(3R)-4,4-difluoropiperidin-3-yl]pyridin-2-yl}-6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine, Serine/threonine-protein kinase pim-1 | 著者 | Murray, J.M, Wallweber, H. | 登録日 | 2017-03-21 | 公開日 | 2017-05-10 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.888 Å) | 主引用文献 | Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability. J. Med. Chem., 60, 2017
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5V80
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7V3Z
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![BU of 7v3z by Molmil](/molmil-images/mine/7v3z) | Structure of cannabinoid receptor type 1(CB1) | 分子名称: | 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, CHOLESTEROL, FLAVIN MONONUCLEOTIDE, ... | 著者 | Liu, Z.J, Shen, L, Hua, T, Yao, D.Q, Wu, L.J. | 登録日 | 2021-08-12 | 公開日 | 2021-11-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1. J.Am.Chem.Soc., 143, 2021
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