7F1T
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![BU of 7f1t by Molmil](/molmil-images/mine/7f1t) | Crystal structure of the human chemokine receptor CCR5 in complex with MIP-1a | 分子名称: | C-C motif chemokine 3,C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION | 著者 | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | 登録日 | 2021-06-09 | 公開日 | 2021-07-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
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7F1Q
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![BU of 7f1q by Molmil](/molmil-images/mine/7f1q) | Cryo-EM structure of the chemokine receptor CCR5 in complex with MIP-1a and Gi | 分子名称: | C-C motif chemokine 3,C-C chemokine receptor type 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhang, H, Chen, K, Tan, Q, Han, S, Zhu, Y, Zhao, Q, Wu, B. | 登録日 | 2021-06-09 | 公開日 | 2021-07-14 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5. Nat Commun, 12, 2021
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7XQE
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![BU of 7xqe by Molmil](/molmil-images/mine/7xqe) | Crystal Structure of human RORgamma (C455E) LBD in complex with compound XY039 | 分子名称: | 2,4-difluoro-N-(1-((4-(trifluoromethyl)benzyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)benzenesulfonamide, ETHANOL, GLYCEROL, ... | 著者 | Wu, X, Li, C, Zhang, Y, Xu, Y. | 登録日 | 2022-05-07 | 公開日 | 2023-05-31 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as ROR gamma inverse agonists against prostate cancer. Acta Pharmacol.Sin., 2024
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6L69
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8K98
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8K9A
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![BU of 8k9a by Molmil](/molmil-images/mine/8k9a) | Cryo-EM structure of DSR2-DSAD1 state 2 | 分子名称: | SIR2-like domain-containing protein, SPbeta prophage-derived uncharacterized protein YotI | 著者 | Zhang, H, Li, Z, Li, X.Z. | 登録日 | 2023-07-31 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Insights into the modulation of bacterial NADase activity by phage proteins. Nat Commun, 15, 2024
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6LOI
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![BU of 6loi by Molmil](/molmil-images/mine/6loi) | |
6JPE
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![BU of 6jpe by Molmil](/molmil-images/mine/6jpe) | Crystal structure of FGFR4 kinase domain with irreversible inhibitor 1 | 分子名称: | Fibroblast growth factor receptor 4, N-[2-[[6-[2-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]amino]pyridin-3-yl]pyrimidin-4-yl]amino]-3-methyl-phenyl]prop-2-enamide, SULFATE ION | 著者 | Chen, X, Dai, S, Zhou, Z, Chen, Y. | 登録日 | 2019-03-26 | 公開日 | 2020-05-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | Development of a Potent and Specific FGFR4 Inhibitor for the Treatment of Hepatocellular Carcinoma. J.Med.Chem., 63, 2020
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6KFW
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7DHJ
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![BU of 7dhj by Molmil](/molmil-images/mine/7dhj) | The co-crystal structure of SARS-CoV-2 main protease with the peptidomimetic inhibitor (S)-2-cinnamamido-N-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)pent-4-ynamide | 分子名称: | (2~{S})-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pent-4-ynamide, 3C-like proteinase | 著者 | Shang, L.Q, Wang, H, Deng, W.L, Xing, S, Wang, Y.X. | 登録日 | 2020-11-15 | 公開日 | 2021-11-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.962 Å) | 主引用文献 | The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate. Eur.J.Med.Chem., 238, 2022
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7DGB
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7DGH
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7DGF
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7DGG
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7DGI
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![BU of 7dgi by Molmil](/molmil-images/mine/7dgi) | |
5TUH
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![BU of 5tuh by Molmil](/molmil-images/mine/5tuh) | |
7WUQ
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![BU of 7wuq by Molmil](/molmil-images/mine/7wuq) | Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4 | 分子名称: | Adhesion G-protein coupled receptor G2,mCherry, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | He, Q.T, Guo, S.C, Xiao, P, Sun, J.P, Yu, X, Gou, L, Kong, L.L, Zhang, L. | 登録日 | 2022-02-09 | 公開日 | 2022-04-27 | 最終更新日 | 2022-05-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature, 604, 2022
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8HZT
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7Y4H
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8HZQ
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7VOP
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![BU of 7vop by Molmil](/molmil-images/mine/7vop) | Cryo-EM structure of Xenopus laevis nuclear pore complex cytoplasmic ring subunit | 分子名称: | GATOR complex protein SEC13, IL4I1 protein, MGC154553 protein, ... | 著者 | Tai, L, Zhu, Y, Sun, F. | 登録日 | 2021-10-14 | 公開日 | 2022-02-02 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (8.7 Å) | 主引用文献 | 8 angstrom structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI. Protein Cell, 13, 2022
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7VCI
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![BU of 7vci by Molmil](/molmil-images/mine/7vci) | Structure of Xenopus laevis NPC nuclear ring asymmetric unit | 分子名称: | GATOR complex protein SEC13, MGC154553 protein, MGC83295 protein, ... | 著者 | Tai, L, Zhu, Y, Sun, F. | 登録日 | 2021-09-03 | 公開日 | 2022-02-02 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (8.1 Å) | 主引用文献 | 8 angstrom structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI. Protein Cell, 13, 2022
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2GKD
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7XHE
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![BU of 7xhe by Molmil](/molmil-images/mine/7xhe) | Crystal structure of CBP bromodomain liganded with CCS151 | 分子名称: | (6S)-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(3R)-1-methylsulfonylpyrrolidin-3-yl]benzimidazol-2-yl]-1-(3-fluoranyl-4-methoxy-phenyl)piperidin-2-one, 1,2-ETHANEDIOL, CREB-binding protein | 著者 | Xu, H, Xiang, Q, Wang, C, Zhang, C, Luo, G, Wu, X, Zhang, Y, Xu, Y. | 登録日 | 2022-04-08 | 公開日 | 2022-07-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain Biochem.Biophys.Res.Commun., 623, 2022
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7XH6
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![BU of 7xh6 by Molmil](/molmil-images/mine/7xh6) | Crystal structure of CBP bromodomain liganded with CCS1477 | 分子名称: | (6S)-1-[3,4-bis(fluoranyl)phenyl]-6-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(4-methoxycyclohexyl)benzimidazol-2-yl]piperidin-2-one, CREB-binding protein, DIMETHYL SULFOXIDE, ... | 著者 | Xu, H, Xiang, Q, Wang, C, Zhang, C, Luo, G, Wu, X, Zhang, Y, Xu, Y. | 登録日 | 2022-04-07 | 公開日 | 2022-07-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain Biochem.Biophys.Res.Commun., 623, 2022
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