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3R7Q
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BU of 3r7q by Molmil
Structure-based design of thienobenzoxepin inhibitors of PI3- kinase
分子名称: N-(2-chlorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Murray, J.M, Wiesmann, C.
登録日2011-03-22
公開日2011-08-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-based design of thienobenzoxepin inhibitors of PI3-kinase.
Bioorg.Med.Chem.Lett., 21, 2011
5V3B
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BU of 5v3b by Molmil
Human A20 OTU domain (WT) with acetamidylated C103
分子名称: Tumor necrosis factor alpha-induced protein 3
著者Langley, D.B, Christ, D, Grey, S.
登録日2017-03-07
公開日2018-03-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
Nat.Immunol., 20, 2019
6H9M
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BU of 6h9m by Molmil
Coiled-coil domain-containing protein 90B residues 43-125 from Homo sapiens fused to a GCN4 adaptor
分子名称: Coiled-coil domain-containing protein 90B, mitochondrial,General control protein GCN4
著者Adlakha, J, Albrecht, R, Lupas, A.N, Hernandez Alvarez, B, Hartmann, M.D.
登録日2018-08-04
公開日2019-02-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles.
Structure, 27, 2019
3G08
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BU of 3g08 by Molmil
Crystal structure of the alpha-galactosylceramide analog OCH in complex with mouse CD1d
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2 microglobulin, ...
著者Zajonc, D.M.
登録日2009-01-27
公開日2009-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells.
J.Immunol., 184, 2010
6CNA
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BU of 6cna by Molmil
GluN1-GluN2B NMDA receptors with exon 5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Furukawa, H, Grant, T, Grigorieff, N.
登録日2018-03-07
公開日2018-10-03
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.
Neuron, 98, 2018
5VRH
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BU of 5vrh by Molmil
Apolipoprotein N-acyltransferase C387S active site mutant
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Apolipoprotein N-acyltransferase, ...
著者Murray, J.M, Noland, C.L.
登録日2017-05-10
公開日2017-07-12
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.137 Å)
主引用文献Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4ES5
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BU of 4es5 by Molmil
Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Bar-headed Gs/Qinghai/15c/2005 (h5n1) with bound m7GTP
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Polymerase basic subunit 2, SULFATE ION
著者Meng, G, Liu, Y, Zheng, X.
登録日2012-04-22
公開日2013-03-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and functional characterization of K339T substitution identified in the PB2 subunit cap-binding pocket of influenza A virus
J.Biol.Chem., 288, 2013
5U09
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BU of 5u09 by Molmil
High-resolution crystal structure of the human CB1 cannabinoid receptor
分子名称: Cannabinoid receptor 1,GlgA glycogen synthase, DI(HYDROXYETHYL)ETHER, N-[(2S,3S)-4-(4-chlorophenyl)-3-(3-cyanophenyl)butan-2-yl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide, ...
著者Shao, Z.H, Yin, J, Rosenbaum, D.
登録日2016-11-23
公開日2016-12-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献High-resolution crystal structure of the human CB1 cannabinoid receptor.
Nature, 2016
5TZR
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BU of 5tzr by Molmil
GPR40 in complex with partial agonist MK-8666
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, Free fatty acid receptor 1,Endolysin,Free fatty acid receptor 1, ...
著者Lu, J, Byrne, N, Patel, S, Sharma, S, Soisson, S.M.
登録日2016-11-22
公開日2017-06-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Nat. Struct. Mol. Biol., 24, 2017
3G0Y
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BU of 3g0y by Molmil
Structure of E. coli FabF(C163Q) in complex with dihydroplatensimycin
分子名称: 3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxodecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2
著者Soisson, S.M, Parthasarathy, G.
登録日2009-01-29
公開日2009-03-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Synthesis and biological evaluation of platensimycin analogs.
Bioorg.Med.Chem.Lett., 19, 2009
2ES3
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BU of 2es3 by Molmil
Crystal Structure of Thrombospondin-1 N-terminal Domain in P1 Form at 1.85A Resolution
分子名称: Thrombospondin-1
著者Tan, K, Wang, J, Lawler, J.
登録日2005-10-25
公開日2006-10-31
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Heparin-induced cis- and trans-Dimerization Modes of the Thrombospondin-1 N-terminal Domain.
J.Biol.Chem., 283, 2008
3SUN
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BU of 3sun by Molmil
RB69 DNA Polymerase (Y567A) Ternary Complex with dTTP Opposite 2AP (AT rich sequence)
分子名称: 5'-D(*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*(2DA))-3', 5'-D(P*CP*(2PR)P*TP*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*G)-3', CALCIUM ION, ...
著者Xia, S, Konigsberg, W.H, Wang, J.
登録日2011-07-11
公開日2011-11-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA Polymerase.
Biochemistry, 50, 2011
7LZ4
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BU of 7lz4 by Molmil
Crystal structure of A211D mutant of Protein Kinase A RIa subunit, a Carney Complex mutation
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
著者Del Rio, J, Wu, J, Taylor, S.S.
登録日2021-03-08
公開日2021-05-26
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (4.155 Å)
主引用文献Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Proc.Natl.Acad.Sci.USA, 118, 2021
4RP8
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BU of 4rp8 by Molmil
Bacterial vitamin C transporter UlaA/SgaT in P21 form
分子名称: ASCORBIC ACID, Ascorbate-specific permease IIC component UlaA, nonyl beta-D-glucopyranoside
著者Wang, J.W.
登録日2014-10-29
公開日2015-03-04
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.359 Å)
主引用文献Crystal structure of a phosphorylation-coupled vitamin C transporter.
Nat.Struct.Mol.Biol., 22, 2015
5OOH
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BU of 5ooh by Molmil
Human biliverdin IX beta reductase: NADP/Erythrosin extra bluish ternary complex
分子名称: Erythrosin, Flavin reductase (NADPH), GLYCEROL, ...
著者Manso, J.A, Pereira, P.J.B.
登録日2017-08-07
公開日2018-03-07
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献In silicoand crystallographic studies identify key structural features of biliverdin IX beta reductase inhibitors having nanomolar potency.
J. Biol. Chem., 293, 2018
3SUO
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BU of 3suo by Molmil
RB69 DNA Polymerase (Y567A) Ternary Complex with dTTP Opposite 2AP (GC rich sequence)
分子名称: 5'-D(*CP*GP*CP*GP*CP*GP*GP*CP*GP*GP*CP*GP*(2DA))-3', 5'-D(P*CP*(2PR)P*TP*CP*GP*CP*CP*GP*CP*CP*GP*CP*GP*CP*GP*G)-3', CALCIUM ION, ...
著者Xia, S, Konigsberg, W.H, Wang, J.
登録日2011-07-11
公開日2011-11-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA Polymerase.
Biochemistry, 50, 2011
5V3P
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BU of 5v3p by Molmil
Human A20 OTU domain (I325N) with acetamidylated C103
分子名称: Tumor necrosis factor alpha-induced protein 3
著者Langley, D.B, Christ, D, Grey, S.
登録日2017-03-07
公開日2018-03-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
Nat.Immunol., 20, 2019
1CN4
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BU of 1cn4 by Molmil
ERYTHROPOIETIN COMPLEXED WITH EXTRACELLULAR DOMAINS OF ERYTHROPOIETIN RECEPTOR
分子名称: PROTEIN (ERYTHROPOIETIN RECEPTOR), PROTEIN (ERYTHROPOIETIN)
著者Stroud, R.M, Reid, S.W.
登録日1999-05-25
公開日1999-08-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Efficiency of signalling through cytokine receptors depends critically on receptor orientation.
Nature, 395, 1998
2CEP
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BU of 2cep by Molmil
ROLE OF MET-230 IN INTRAMOLECULAR ELECTRON TRANSFER BETWEEN THE OXYFERRYL HEME AND TRP 191 IN CYTOCHROME C PEROXIDASE COMPOUND II
分子名称: CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE
著者Han, G.W, Miller, M.A, Kraut, J.
登録日1994-05-31
公開日1994-08-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Role of methionine 230 in intramolecular electron transfer between the oxyferryl heme and tryptophan 191 in cytochrome c peroxidase compound II.
Biochemistry, 33, 1994
5UL5
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BU of 5ul5 by Molmil
Crystal structure of RPE65 in complex with MB-004 and palmitate
分子名称: (1R)-3-amino-1-{3-[(2-propylpentyl)oxy]phenyl}propan-1-ol, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, FE (II) ION, ...
著者Kiser, P.D, Palczewski, K.
登録日2017-01-24
公開日2017-05-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Rational Tuning of Visual Cycle Modulator Pharmacodynamics.
J. Pharmacol. Exp. Ther., 362, 2017
2KV8
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BU of 2kv8 by Molmil
Solution structure ofRGS12 PDZ domain
分子名称: Regulator of G-protein signaling 12
著者Lu, G, Ji, P, Huang, H.
登録日2010-03-10
公開日2011-03-02
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Determining the Molecular Basis for the pH-dependent Interaction between the PDZ of Human RGS12 and MEK2
To be Published
7FB3
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BU of 7fb3 by Molmil
SARS-CoV-2 spike protein in one-RBD weak state after CTSL-treatment
分子名称: Spike glycoprotein
著者Zhu, Y, Tai, L.H, Sun, F.
登録日2021-07-08
公開日2022-07-13
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Novel sites for Cathepsin L cleavage in SARS-CoV-2 spike guide treatment strategies
To Be Published
7FB0
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BU of 7fb0 by Molmil
SARS-CoV-2 spike protein in closed state
分子名称: Spike glycoprotein
著者Zhu, Y, Tai, L.H, Sun, F.
登録日2021-07-08
公開日2022-07-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Novel sites for Cathepsin L cleavage in SARS-CoV-2 spike guide treatment strategies
To Be Published
7FB1
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BU of 7fb1 by Molmil
SARS-CoV-2 spike protein in one-RBD open state
分子名称: Spike glycoprotein
著者Zhu, Y, Tai, L.H, Sun, F.
登録日2021-07-08
公開日2022-07-13
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Novel sites for Cathepsin L cleavage in SARS-CoV-2 spike guide treatment strategies
To Be Published
7FB4
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BU of 7fb4 by Molmil
SARS-CoV-2 spike protein in two-RBD weak state after CTSL-treatment
分子名称: Spike glycoprotein
著者Zhu, Y, Tai, L.H, Sun, F.
登録日2021-07-08
公開日2022-07-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Novel sites for Cathepsin L cleavage in SARS-CoV-2 spike guide treatment strategies
To Be Published

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