3G0Y

Structure of E. coli FabF(C163Q) in complex with dihydroplatensimycin

Summary for 3G0Y

• Entry DOI: 10.2210/pdb3g0y/pdb
• Related: 2GFX
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxodecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid (3 entities in total)
• Functional Keywords: ketoacyl synthase, antibiotic, acyltransferase, fatty acid biosynthesis, lipid synthesis, transferase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 45105.78

Authors

Soisson, S.M.,Parthasarathy, G. (deposition date: 2009-01-29, release date: 2009-03-17, Last modification date: 2023-09-06)

• Primary citation: Shen, H.C.,Ding, F.X.,Singh, S.B.,Parthasarathy, G.,Soisson, S.M.,Ha, S.N.,Chen, X.,Kodali, S.,Wang, J.,Dorso, K.,Tata, J.R.,Hammond, M.L.,Maccoss, M.,Colletti, S.L.; Synthesis and biological evaluation of platensimycin analogs.; Bioorg.Med.Chem.Lett., 19:1623-1627, 2009; PubMed: 19233644; DOI: 10.1016/j.bmcl.2009.02.006

Experimental method

X-RAY DIFFRACTION (2.6 Å)