7JRN
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![BU of 7jrn by Molmil](/molmil-images/mine/7jrn) | Crystal structure of the wild type SARS-CoV-2 papain-like protease (PLPro) with inhibitor GRL0617 | 分子名称: | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, Non-structural protein 3, SULFATE ION, ... | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-08-12 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay. Acs Cent.Sci., 7, 2021
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7WSO
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![BU of 7wso by Molmil](/molmil-images/mine/7wso) | Structure of a membrane protein G | 分子名称: | B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, Immunoglobulin heavy constant gamma 1 | 著者 | Ma, X, Zhu, Y, Chen, Y, Huang, Z. | 登録日 | 2022-01-30 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Cryo-EM structures of two human B cell receptor isotypes. Science, 377, 2022
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2FZL
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2FWR
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![BU of 2fwr by Molmil](/molmil-images/mine/2fwr) | Structure of Archaeoglobus Fulgidis XPB | 分子名称: | DNA repair protein RAD25, ISOPROPYL ALCOHOL, PHOSPHATE ION | 著者 | Fan, L, Arvai, A.S, Tainer, J.A. | 登録日 | 2006-02-02 | 公開日 | 2006-04-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Conserved XPB Core Structure and Motifs for DNA Unwinding: Implications for Pathway Selection of Transcription or Excision Repair Mol.Cell, 22, 2006
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7XT6
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![BU of 7xt6 by Molmil](/molmil-images/mine/7xt6) | Structure of a membrane protein M3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B-cell antigen receptor complex-associated protein alpha chain, ... | 著者 | Ma, X, Zhu, Y, Chen, Y, Huang, Z. | 登録日 | 2022-05-16 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Cryo-EM structures of two human B cell receptor isotypes. Science, 377, 2022
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2KMU
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![BU of 2kmu by Molmil](/molmil-images/mine/2kmu) | |
4KN0
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![BU of 4kn0 by Molmil](/molmil-images/mine/4kn0) | |
7VSQ
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![BU of 7vsq by Molmil](/molmil-images/mine/7vsq) | |
7VSP
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4KMX
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![BU of 4kmx by Molmil](/molmil-images/mine/4kmx) | Human folate receptor alpha (FOLR1) at acidic pH, hexagonal form | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Wibowo, A.S, Dann III, C.E. | 登録日 | 2013-05-08 | 公開日 | 2013-08-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KN2
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![BU of 4kn2 by Molmil](/molmil-images/mine/4kn2) | Human folate receptor beta (FOLR2) in complex with antifolate pemetrexed | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, CHLORIDE ION, ... | 著者 | Wibowo, A.S, Dann III, C.E. | 登録日 | 2013-05-08 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
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7VRS
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![BU of 7vrs by Molmil](/molmil-images/mine/7vrs) | The complex of Acyltransferase and Acyl Carrier Protein Domains from module 9 of Salinomycin Polyketide Synthase | 分子名称: | 1,1'-butane-1,4-diylbis(1H-pyrrole-2,5-dione), 4'-PHOSPHOPANTETHEINE, Type I modular polyketide synthase | 著者 | Feng, Y, Zheng, J. | 登録日 | 2021-10-24 | 公開日 | 2022-06-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural visualization of transient interactions between the cis-acting acyltransferase and acyl carrier protein of the salinomycin modular polyketide synthase. Acta Crystallogr D Struct Biol, 78, 2022
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4OO8
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![BU of 4oo8 by Molmil](/molmil-images/mine/4oo8) | Crystal structure of Streptococcus pyogenes Cas9 in complex with guide RNA and target DNA | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*CP*CP*AP*GP*CP*CP*AP*AP*GP*CP*GP*CP*AP*CP*CP*TP*AP*AP*TP*TP*TP*CP*C)-3'), RNA (97-MER) | 著者 | Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2014-01-31 | 公開日 | 2014-02-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of Cas9 in complex with guide RNA and target DNA Cell(Cambridge,Mass.), 156, 2014
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7VTI
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![BU of 7vti by Molmil](/molmil-images/mine/7vti) | Crystal structure of the Cas13bt3-crRNA binary complex | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ... | 著者 | Nakagawa, R, Takeda, N.S, Tomita, A, Hirano, H, Kusakizako, T, Nishizawa, T, Yamashita, K, Nishimasu, H, Nureki, O. | 登録日 | 2021-10-29 | 公開日 | 2022-08-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Structure and engineering of the minimal type VI CRISPR-Cas13bt3. Mol.Cell, 82, 2022
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7K0V
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![BU of 7k0v by Molmil](/molmil-images/mine/7k0v) | Crystal structure of bRaf in complex with inhibitor GNE-0749 | 分子名称: | CHLORIDE ION, N-(3,3-dimethylbutyl)-N'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}urea, Non-specific serine/threonine protein kinase | 著者 | Yin, J, Eigenbrot, C.E, Wang, W. | 登録日 | 2020-09-06 | 公開日 | 2021-05-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a 5-Fluoro-4-(3 H )-quinazolinone Aryl Urea pan-RAF Kinase Inhibitor. J.Med.Chem., 64, 2021
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5T5T
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![BU of 5t5t by Molmil](/molmil-images/mine/5t5t) | AMPK bound to allosteric activator | 分子名称: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... | 著者 | Calabrese, M.F, Kurumbail, R.G. | 登録日 | 2016-08-31 | 公開日 | 2017-03-29 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.46 Å) | 主引用文献 | Selective Activation of AMPK beta 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy. J. Pharmacol. Exp. Ther., 361, 2017
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7KSP
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![BU of 7ksp by Molmil](/molmil-images/mine/7ksp) | Crystal structure of hSAMD9_DBD with DNA | 分子名称: | DNA, Sterile alpha motif domain-containing protein 9 | 著者 | Peng, S, Pathak, P, Xiang, Y, Deng, J. | 登録日 | 2020-11-23 | 公開日 | 2022-01-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure and function of an effector domain in antiviral factors and tumor suppressors SAMD9 and SAMD9L. Proc.Natl.Acad.Sci.USA, 119, 2022
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7LYI
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![BU of 7lyi by Molmil](/molmil-images/mine/7lyi) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAWJ9-36-3 | 分子名称: | 3C-like proteinase, GLYCEROL, SODIUM ION, ... | 著者 | Sacco, M, Wang, J, Chen, Y. | 登録日 | 2021-03-07 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir. Acs Pharmacol Transl Sci, 4, 2021
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7LYH
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![BU of 7lyh by Molmil](/molmil-images/mine/7lyh) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAWJ9-36-1 | 分子名称: | 3C-like proteinase, GLYCEROL, benzyl (1S,3aR,6aS)-1-({(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}carbamoyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate | 著者 | Sacco, M, Wang, J, Chen, Y. | 登録日 | 2021-03-07 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir. Acs Pharmacol Transl Sci, 4, 2021
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4JPH
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![BU of 4jph by Molmil](/molmil-images/mine/4jph) | Crystal structure of Protein Related to DAN and Cerberus (PRDC) | 分子名称: | CITRIC ACID, GLUTATHIONE, GLYCEROL, ... | 著者 | Deng, X, Nolan, K.T, Kattamuri, C, Thompson, T.B. | 登録日 | 2013-03-19 | 公開日 | 2013-07-24 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure of protein related to dan and cerberus: insights into the mechanism of bone morphogenetic protein antagonism. Structure, 21, 2013
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4KMZ
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![BU of 4kmz by Molmil](/molmil-images/mine/4kmz) | Human folate receptor beta (FOLR2) in complex with the folate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, FOLIC ACID, ... | 著者 | Wibowo, A.S, Dann III, C.E. | 登録日 | 2013-05-08 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
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3CQW
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![BU of 3cqw by Molmil](/molmil-images/mine/3cqw) | Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor | 分子名称: | 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, Glycogen synthase kinase-3 beta, MANGANESE (II) ION, ... | 著者 | Pandit, J. | 登録日 | 2008-04-03 | 公開日 | 2008-05-27 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Synthesis and structure based optimization of novel Akt inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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3CQU
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![BU of 3cqu by Molmil](/molmil-images/mine/3cqu) | Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor | 分子名称: | Glycogen synthase kinase-3 beta, N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, RAC-alpha serine/threonine-protein kinase | 著者 | Pandit, J. | 登録日 | 2008-04-03 | 公開日 | 2008-05-27 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Synthesis and structure based optimization of novel Akt inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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4KMY
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![BU of 4kmy by Molmil](/molmil-images/mine/4kmy) | Human folate receptor beta (FOLR2) at neutral pH | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Folate receptor beta, POTASSIUM ION | 著者 | Wibowo, A.S, Dann III, C.E. | 登録日 | 2013-05-08 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | 主引用文献 | Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition. Proc.Natl.Acad.Sci.USA, 110, 2013
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7LTZ
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![BU of 7ltz by Molmil](/molmil-images/mine/7ltz) | Bruton's tyrosine kinase in complex with compound 51 | 分子名称: | 1-~{tert}-butyl-~{N}-[(5~{R})-8-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-2-(oxetan-3-yl)-1,3,4,5-tetrahydro-2-benzazepin-5-yl]-1,2,3-triazole-4-carboxamide, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ACETATE ION, ... | 著者 | Metrick, C.M, Marcotte, D.J. | 登録日 | 2021-02-20 | 公開日 | 2022-01-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis. J.Med.Chem., 65, 2022
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