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7SAS
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BU of 7sas by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
著者Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
登録日2021-09-23
公開日2022-03-09
最終更新日2022-05-25
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
5UQ9
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BU of 5uq9 by Molmil
Crystal structure of 6-phosphogluconate dehydrogenase with ((4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate
分子名称: 6-phosphogluconate dehydrogenase, decarboxylating, [(4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl dihydrogen phosphate
著者Leonard, P.G.
登録日2017-02-07
公開日2018-08-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.
Cell Rep, 26, 2019
8GTD
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BU of 8gtd by Molmil
Cryo-EM model of the marine siphophage vB_DshS-R4C portal-adaptor complex
分子名称: Head-to-tail joining protein, Portal protein
著者Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N.
登録日2022-09-08
公開日2023-07-12
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (4.7 Å)
主引用文献Structure and proposed DNA delivery mechanism of a marine roseophage.
Nat Commun, 14, 2023
8GTA
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BU of 8gta by Molmil
Cryo-EM structure of the marine siphophage vB_Dshs-R4C capsid
分子名称: Major capsid protein
著者Sun, H, Huang, Y, Zheng, Q, Li, S, Zhang, R, Xia, N.
登録日2022-09-07
公開日2023-07-12
最終更新日2023-08-16
実験手法ELECTRON MICROSCOPY (3.63 Å)
主引用文献Structure and proposed DNA delivery mechanism of a marine roseophage.
Nat Commun, 14, 2023
8GTF
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BU of 8gtf by Molmil
Cryo-EM model of the marine siphophage vB_DshS-R4C stopper-terminator complex
分子名称: Head-to-tail joining protein, Major tail protein, Terminator protein
著者Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N.
登録日2022-09-08
公開日2023-07-12
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (6.6 Å)
主引用文献Structure and proposed DNA delivery mechanism of a marine roseophage.
Nat Commun, 14, 2023
8GTB
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BU of 8gtb by Molmil
Cryo-EM structure of the marine siphophage vB_DshS-R4C tail tube protein
分子名称: Major tail protein
著者Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N.
登録日2022-09-08
公開日2023-07-12
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献Structure and proposed DNA delivery mechanism of a marine roseophage.
Nat Commun, 14, 2023
8GTC
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BU of 8gtc by Molmil
Cryo-EM model of the marine siphophage vB_DshS-R4C baseplate-tail complex
分子名称: Distal tail protein, Hub protein, Major tail protein, ...
著者Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N.
登録日2022-09-08
公開日2023-07-12
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structure and proposed DNA delivery mechanism of a marine roseophage.
Nat Commun, 14, 2023
5H7V
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BU of 5h7v by Molmil
Structure of full-length extracellular domain of HAI-1 at pH 4.6
分子名称: Kunitz-type protease inhibitor 1
著者Liu, M, Huang, M.
登録日2016-11-21
公開日2017-03-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (3.82 Å)
主引用文献The crystal structure of a multidomain protease inhibitor (HAI-1) reveals the mechanism of its auto-inhibition
J. Biol. Chem., 292, 2017
3HI4
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BU of 3hi4 by Molmil
Switching catalysis from hydrolysis to perhydrolysis in P. fluorescens esterase
分子名称: ACETATE ION, Arylesterase, GLYCEROL, ...
著者Purpero, V.M.
登録日2009-05-18
公開日2010-02-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase.
Biochemistry, 49, 2010
3HEA
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BU of 3hea by Molmil
The L29P/L124I mutation of Pseudomonas fluorescens esterase
分子名称: Arylesterase, ETHYL ACETATE, GLYCEROL, ...
著者Kazlauskas, R.J, Schrag, J.D, Cheeseman, J.D, Morley, K.L.
登録日2009-05-08
公開日2010-03-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Switching catalysis from hydrolysis to perhydrolysis in Pseudomonas fluorescens esterase.
Biochemistry, 49, 2010
6A4M
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BU of 6a4m by Molmil
Structure of urate oxidase from Bacillus subtilis 168
分子名称: GLYCEROL, Uric acid degradation bifunctional protein PucL
著者Jiang, Y.Y.
登録日2018-06-20
公開日2019-06-26
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Urate Oxidase from Bacillus Subtilis 168
Crystallography Reports, 64, 2019
6L3F
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BU of 6l3f by Molmil
The structure of UTP:RNA uridylyltransferase 1 (URT1) in in Arabidopsis
分子名称: UTP:RNA uridylyltransferase 1
著者Lingru, Z.
登録日2019-10-10
公開日2020-01-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.975 Å)
主引用文献Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
Biochem.Biophys.Res.Commun., 524, 2020
6L8K
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BU of 6l8k by Molmil
Structure of URT1 in complex with UTP
分子名称: URIDINE 5'-TRIPHOSPHATE, UTP:RNA uridylyltransferase 1
著者Lingru, Z.
登録日2019-11-06
公開日2020-01-29
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.999 Å)
主引用文献Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
Biochem.Biophys.Res.Commun., 524, 2020
5YYF
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BU of 5yyf by Molmil
Crystal structure of AF9 YEATS domain in complex with a peptide inhibitor "PHQ-H3(Q5-K9)" modified at K9 with 2-furancarboyl group
分子名称: 2-FUROIC ACID, Peptide inhibitor PHQ-H3(Q5-K9), Protein AF-9, ...
著者Li, Y, Li, H.
登録日2017-12-09
公開日2018-11-07
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking.
Nat. Chem. Biol., 14, 2018
3TYQ
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BU of 3tyq by Molmil
SAR development and discovery of potent indole-based inhibitors of the hepatitis c virus NS5B polymerase
分子名称: 5-ethyl-1-(2-fluoro-5-nitrobenzyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase
著者Lesburg, C.A, Chen, K.X.
登録日2011-09-26
公開日2012-02-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors.
J.Med.Chem., 55, 2012
3TYV
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BU of 3tyv by Molmil
SAR development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase
分子名称: N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase
著者Lesburg, C.A, Chen, K.X.
登録日2011-09-26
公開日2012-02-01
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase.
J.Med.Chem., 55, 2012
5ZI6
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BU of 5zi6 by Molmil
The RING domain structure of MEX-3C
分子名称: RNA-binding E3 ubiquitin-protein ligase MEX3C, ZINC ION
著者Moududee, S.A, Tang, Y.
登録日2018-03-14
公開日2018-10-24
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and functional characterization of hMEX-3C Ring finger domain as an E3 ubiquitin ligase
Protein Sci., 27, 2018
8FLU
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BU of 8flu by Molmil
Human PTH1R in complex with LA-PTH and Gs
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLR
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BU of 8flr by Molmil
Human PTH1R in complex with PTHrP and Gs
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLT
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BU of 8flt by Molmil
Human PTH1R in complex with M-PTH(1-14) and Gs
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (3.03 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLQ
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BU of 8flq by Molmil
Human PTH1R in complex with PTH(1-34) and Gs
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (2.55 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8FLS
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BU of 8fls by Molmil
Human PTH1R in complex with Abaloparatide and Gs
分子名称: Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M.
登録日2022-12-22
公開日2023-04-26
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献Molecular insights into peptide agonist engagement with the PTH receptor.
Structure, 31, 2023
8SKQ
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BU of 8skq by Molmil
RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA)
分子名称: TNA-containing RNA oligonucleotide
著者Harp, J.M, Egli, M.
登録日2023-04-20
公開日2024-02-14
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
J.Am.Chem.Soc., 145, 2023
5Y0U
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BU of 5y0u by Molmil
The solution structure of AEBP2 C2H2 zinc fingers
分子名称: ZINC ION, Zinc finger protein AEBP2
著者Sun, A, Shi, Y, Wu, J.
登録日2017-07-18
公開日2018-08-01
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4.
Protein Cell, 9, 2018
6ASG
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BU of 6asg by Molmil
Crystal structure of Thermus thermophilus RNA polymerase core enzyme
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Liu, Y, Lin, W, Ying, R, Ebright, R.H.
登録日2017-08-24
公開日2018-04-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Mol. Cell, 70, 2018

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