5UQ9
Crystal structure of 6-phosphogluconate dehydrogenase with ((4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate
Summary for 5UQ9
Entry DOI | 10.2210/pdb5uq9/pdb |
Related | 2JKV 4GWG 4GWK |
Descriptor | 6-phosphogluconate dehydrogenase, decarboxylating, [(4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl dihydrogen phosphate (2 entities in total) |
Functional Keywords | rossmann fold, pentose phosphate pathway, dehydrogenase, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 430379.19 |
Authors | Leonard, P.G. (deposition date: 2017-02-07, release date: 2018-08-22, Last modification date: 2023-10-04) |
Primary citation | Sun, Y.,Bandi, M.,Lofton, T.,Smith, M.,Bristow, C.A.,Carugo, A.,Rogers, N.,Leonard, P.,Chang, Q.,Mullinax, R.,Han, J.,Shi, X.,Seth, S.,Meyers, B.A.,Miller, M.,Miao, L.,Ma, X.,Feng, N.,Giuliani, V.,Geck Do, M.,Czako, B.,Palmer, W.S.,Mseeh, F.,Asara, J.M.,Jiang, Y.,Morlacchi, P.,Zhao, S.,Peoples, M.,Tieu, T.N.,Warmoes, M.O.,Lorenzi, P.L.,Muller, F.L.,DePinho, R.A.,Draetta, G.F.,Toniatti, C.,Jones, P.,Heffernan, T.P.,Marszalek, J.R. Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Rep, 26:469-482.e5, 2019 Cited by PubMed: 30625329DOI: 10.1016/j.celrep.2018.12.043 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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