Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5UQ9

Crystal structure of 6-phosphogluconate dehydrogenase with ((4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006098	biological_process	pentose-phosphate shunt
A	0006739	biological_process	NADP+ metabolic process
A	0006740	biological_process	NADPH regeneration
A	0009051	biological_process	pentose-phosphate shunt, oxidative branch
A	0016491	molecular_function	oxidoreductase activity
A	0019521	biological_process	D-gluconate metabolic process
A	0030246	molecular_function	carbohydrate binding
A	0031406	molecular_function	carboxylic acid binding
A	0050661	molecular_function	NADP binding
A	0070062	cellular_component	extracellular exosome
B	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006098	biological_process	pentose-phosphate shunt
B	0006739	biological_process	NADP+ metabolic process
B	0006740	biological_process	NADPH regeneration
B	0009051	biological_process	pentose-phosphate shunt, oxidative branch
B	0016491	molecular_function	oxidoreductase activity
B	0019521	biological_process	D-gluconate metabolic process
B	0030246	molecular_function	carbohydrate binding
B	0031406	molecular_function	carboxylic acid binding
B	0050661	molecular_function	NADP binding
B	0070062	cellular_component	extracellular exosome
C	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006098	biological_process	pentose-phosphate shunt
C	0006739	biological_process	NADP+ metabolic process
C	0006740	biological_process	NADPH regeneration
C	0009051	biological_process	pentose-phosphate shunt, oxidative branch
C	0016491	molecular_function	oxidoreductase activity
C	0019521	biological_process	D-gluconate metabolic process
C	0030246	molecular_function	carbohydrate binding
C	0031406	molecular_function	carboxylic acid binding
C	0050661	molecular_function	NADP binding
C	0070062	cellular_component	extracellular exosome
D	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006098	biological_process	pentose-phosphate shunt
D	0006739	biological_process	NADP+ metabolic process
D	0006740	biological_process	NADPH regeneration
D	0009051	biological_process	pentose-phosphate shunt, oxidative branch
D	0016491	molecular_function	oxidoreductase activity
D	0019521	biological_process	D-gluconate metabolic process
D	0030246	molecular_function	carbohydrate binding
D	0031406	molecular_function	carboxylic acid binding
D	0050661	molecular_function	NADP binding
D	0070062	cellular_component	extracellular exosome
E	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006098	biological_process	pentose-phosphate shunt
E	0006739	biological_process	NADP+ metabolic process
E	0006740	biological_process	NADPH regeneration
E	0009051	biological_process	pentose-phosphate shunt, oxidative branch
E	0016491	molecular_function	oxidoreductase activity
E	0019521	biological_process	D-gluconate metabolic process
E	0030246	molecular_function	carbohydrate binding
E	0031406	molecular_function	carboxylic acid binding
E	0050661	molecular_function	NADP binding
E	0070062	cellular_component	extracellular exosome
F	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006098	biological_process	pentose-phosphate shunt
F	0006739	biological_process	NADP+ metabolic process
F	0006740	biological_process	NADPH regeneration
F	0009051	biological_process	pentose-phosphate shunt, oxidative branch
F	0016491	molecular_function	oxidoreductase activity
F	0019521	biological_process	D-gluconate metabolic process
F	0030246	molecular_function	carbohydrate binding
F	0031406	molecular_function	carboxylic acid binding
F	0050661	molecular_function	NADP binding
F	0070062	cellular_component	extracellular exosome
G	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006098	biological_process	pentose-phosphate shunt
G	0006739	biological_process	NADP+ metabolic process
G	0006740	biological_process	NADPH regeneration
G	0009051	biological_process	pentose-phosphate shunt, oxidative branch
G	0016491	molecular_function	oxidoreductase activity
G	0019521	biological_process	D-gluconate metabolic process
G	0030246	molecular_function	carbohydrate binding
G	0031406	molecular_function	carboxylic acid binding
G	0050661	molecular_function	NADP binding
G	0070062	cellular_component	extracellular exosome
H	0004616	molecular_function	phosphogluconate dehydrogenase (decarboxylating) activity
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006098	biological_process	pentose-phosphate shunt
H	0006739	biological_process	NADP+ metabolic process
H	0006740	biological_process	NADPH regeneration
H	0009051	biological_process	pentose-phosphate shunt, oxidative branch
H	0016491	molecular_function	oxidoreductase activity
H	0019521	biological_process	D-gluconate metabolic process
H	0030246	molecular_function	carbohydrate binding
H	0031406	molecular_function	carboxylic acid binding
H	0050661	molecular_function	NADP binding
H	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 8HS F 501

Chain	Residue
E	ASN103
E	TYR192
E	LYS261
E	ARG288
F	ARG447
F	PHE450
F	GLY451
F	HIS453

Functional Information from PROSITE/UniProt

site_id	PS00461
Number of Residues	13
Details	6PGD 6-phosphogluconate dehydrogenase signature. IrDsaGQKGTGkW

Chain	Residue	Details
A	ILE254-TRP266

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	72
Details	Binding site: {"description":"in other chain","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Structure of human phosphogluconate dehydrogenase in complex with NADPH at 2.53 A.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	56
Details	Binding site: {"description":"in other chain","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DCD0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9DCD0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)