8EQB
 
 | | FAM46C/BCCIPalpha/Nanobody complex | | 分子名称: | Isoform 2 of BRCA2 and CDKN1A-interacting protein, Synthetic nanobody 1, Terminal nucleotidyltransferase 5C | | 著者 | Liu, S, Chen, H, Yin, Y, Bai, X, Zhang, X. | | 登録日 | 2022-10-07 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | | 主引用文献 | Inhibition of FAM46/TENT5 activity by BCCIP alpha adopting a unique fold.
Sci Adv, 9, 2023
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3FPD
 | | G9a-like protein lysine methyltransferase inhibition by BIX-01294 | | 分子名称: | Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine, ... | | 著者 | Chang, Y, Zhang, X, Horton, J.R, Cheng, X. | | 登録日 | 2009-01-05 | | 公開日 | 2009-02-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
Nat.Struct.Mol.Biol., 16, 2009
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3EA3
 | | Crystal Structure of the Y246S/Y247S/Y248S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis | | 分子名称: | 1-phosphatidylinositol phosphodiesterase, MANGANESE (II) ION | | 著者 | Shi, X, Shao, C, Zhang, X, Zambonelli, C, Redfied, A.G, Head, J.F, Seaton, B.A, Roberts, M.F. | | 登録日 | 2008-08-24 | | 公開日 | 2009-04-14 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Modulation of Bacillus thuringiensis Phosphatidylinositol-specific Phospholipase C Activity by Mutations in the Putative Dimerization Interface.
J.Biol.Chem., 284, 2009
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1SQO
 | | Substituted 2-Naphthamidine Inhibitors of Urokinase | | 分子名称: | 8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMIDE, SULFATE ION, Urokinase-type plasminogen activator | | 著者 | Wendt, M.D, Geyer, A, McClellan, W.J, Rockway, T.W, Weitzberg, M, Zhao, X, Mantei, R, Stewart, K, Nienaber, V, Klinghofer, V, Giranda, V.L. | | 登録日 | 2004-03-19 | | 公開日 | 2004-04-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Interaction with the S1beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
Bioorg.Med.Chem.Lett., 14, 2004
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1SQA
 | | Substituted 2-Naphthamidine Inhibitors of Urokinase | | 分子名称: | 6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENYL]-4-(PYRIMIDIN-2-YLAMINO)-2-NAPHTHAMIDE, SULFATE ION, Urokinase-type plasminogen activator | | 著者 | Wendt, M.D, Geyer, A, McClellan, W.J, Rockway, T.W, Weitzberg, M, Zhao, X, Stewart, K, Nienaber, V, Klinghofer, V, Giranda, V.L. | | 登録日 | 2004-03-18 | | 公開日 | 2004-04-27 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Interaction with the S1beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors.
Bioorg.Med.Chem.Lett., 14, 2004
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3EA2
 | | Crystal Structure of the Myo-inositol bound Y247S/Y251S Mutant of Phosphatidylinositol-Specific Phospholipase C from Bacillus Thuringiensis | | 分子名称: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1-phosphatidylinositol phosphodiesterase, ZINC ION | | 著者 | Shi, X, Shao, C, Zhang, X, Zambonelli, C, Redfied, A.G, Head, J.F, Seaton, B.A, Roberts, M.F. | | 登録日 | 2008-08-24 | | 公開日 | 2009-04-14 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Modulation of bacillus thuringiensis phosphatidylinositol-specific phospholipase C activity by mutations in the putative dimerization interface.
J.Biol.Chem., 284, 2009
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1WE1
 | | Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC6803 in complex with heme | | 分子名称: | CHLORIDE ION, Heme oxygenase 1, ISOPROPYL ALCOHOL, ... | | 著者 | Sugishima, M, Migita, C.T, Zhang, X, Yoshida, T, Fukuyama, K. | | 登録日 | 2004-05-21 | | 公開日 | 2004-12-21 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of heme oxygenase-1 from cyanobacterium Synechocystis sp. PCC 6803 in complex with heme
Eur.J.Biochem., 271, 2004
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2LIT
 | | NMR Solution Structure of Yeast Iso-1-cytochrome c Mutant P71H in reduced states | | 分子名称: | Cytochrome c iso-1, HEME C | | 著者 | Lan, W, Wang, Z, Yang, Z, Zhu, J, Ying, T, Jiang, X, Zhang, X, Wu, H, Liu, M, Tan, X, Cao, C, Huang, Z.X. | | 登録日 | 2011-08-31 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conformational toggling of yeast iso-1-cytochrome C in the oxidized and reduced States.
Plos One, 6, 2011
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1RKU
 | | Crystal Structure of ThrH gene product of Pseudomonas Aeruginosa | | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, homoserine kinase | | 著者 | Singh, S.K, Yang, K, Subramanian, K, Karthikeyan, S, Huynh, T, Zhang, X, Phillips, M.A, Zhang, H. | | 登録日 | 2003-11-23 | | 公開日 | 2004-03-30 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity.
J.Biol.Chem., 279, 2004
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2LIR
 | | NMR Solution Structure of Yeast Iso-1-cytochrome c Mutant P71H in oxidized states | | 分子名称: | Cytochrome c iso-1, HEME C | | 著者 | Lan, W, Wang, Z, Yang, Z, Zhu, J, Ying, T, Jiang, X, Zhang, X, Wu, H, Liu, M, Tan, X, Cao, C, Huang, Z.X. | | 登録日 | 2011-08-31 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conformational toggling of yeast iso-1-cytochrome C in the oxidized and reduced States.
Plos One, 6, 2011
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5TBP
 | | Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003 | | 分子名称: | ACETATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Aleshin, A.E, Liddington, R.C, Su, Y, Zhang, X. | | 登録日 | 2016-09-12 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha.
Nat Commun, 8, 2017
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1RKV
 | | Structure of Phosphate complex of ThrH from Pseudomonas aeruginosa | | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Singh, S.K, Yang, K, Subramanian, K, Karthikeyan, S, Huynh, T, Zhang, X, Phillips, M.A, Zhang, H. | | 登録日 | 2003-11-23 | | 公開日 | 2004-03-30 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity.
J.Biol.Chem., 279, 2004
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3J6C
 | | Cryo-EM structure of MAVS CARD filament | | 分子名称: | Mitochondrial antiviral-signaling protein | | 著者 | Xu, H, He, X, Zheng, H, Huang, L.J, Hou, F, Yu, Z, de la Cruz, M.J, Borkowski, B, Zhang, X, Chen, Z.J, Jiang, Q.-X. | | 登録日 | 2014-02-04 | | 公開日 | 2014-03-05 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (9.6 Å) | | 主引用文献 | Structural basis for the prion-like MAVS filaments in antiviral innate immunity.
Elife, 3, 2014
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7WQR
 | | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 28 | | 分子名称: | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ~{N}-(3-chlorophenyl)-2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]benzamide | | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | | 登録日 | 2022-01-25 | | 公開日 | 2023-01-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.124 Å) | | 主引用文献 | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer.
Eur.J.Med.Chem., 247, 2022
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7WQS
 | | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 25 | | 分子名称: | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(3-methoxyphenyl)benzamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | | 登録日 | 2022-01-26 | | 公開日 | 2023-01-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer.
Eur.J.Med.Chem., 247, 2022
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7WQM
 | | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 24 | | 分子名称: | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(2-methoxyphenyl)benzamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | | 登録日 | 2022-01-25 | | 公開日 | 2023-01-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer.
Eur.J.Med.Chem., 247, 2022
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3SWC
 | | GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me2 peptide | | 分子名称: | DNA (cytosine-5)-methyltransferase 3A, Histone-lysine N-methyltransferase EHMT1, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Chang, Y, Horton, J.R, Zhang, X, Cheng, X. | | 登録日 | 2011-07-13 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.332 Å) | | 主引用文献 | MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
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4EW0
 | | mouse MBD4 glycosylase domain in complex with a G:5hmU (5-hydroxymethyluracil) mismatch | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*CP*AP*TP*GP*(5HU)P*GP*CP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*GP*CP*GP*CP*AP*TP*GP*G)-3'), ... | | 著者 | Hashimoto, H, Zhang, X, Cheng, X. | | 登録日 | 2012-04-26 | | 公開日 | 2012-07-11 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation.
Nucleic Acids Res., 40, 2012
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5EYO
 | | The crystal structure of the Max bHLH domain in complex with 5-carboxyl cytosine DNA | | 分子名称: | DNA (5'-D(*AP*GP*TP*AP*GP*CP*AP*(1CC)P*GP*TP*GP*CP*TP*AP*CP*T)-3'), Protein max | | 著者 | Wang, D, Hashimoto, H, Zhang, X, Cheng, X. | | 登録日 | 2015-11-25 | | 公開日 | 2016-12-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma.
Nucleic Acids Res., 45, 2017
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4R2E
 | | Wilms Tumor Protein (WT1) zinc fingers in complex with methylated DNA | | 分子名称: | DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5CM)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), Wilms tumor protein, ... | | 著者 | Hashimoto, H, Olanrewaju, Y.O, Zheng, Y, Wilson, G.G, Zhang, X, Cheng, X. | | 登録日 | 2014-08-11 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.
Genes Dev., 28, 2014
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4R2R
 | | Wilms Tumor Protein (WT1) zinc fingers in complex with carboxylated DNA | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(1CC)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), ... | | 著者 | Hashimoto, H, Olanrewaju, Y.O, Zheng, Y, Wilson, G.G, Zhang, X, Cheng, X. | | 登録日 | 2014-08-12 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.089 Å) | | 主引用文献 | Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.
Genes Dev., 28, 2014
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2C9C
 | | Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PSP OPERON TRANSCRIPTIONAL ACTIVATOR | | 著者 | Rappas, M, Schumacher, J, Niwa, H, Buck, M, Zhang, X. | | 登録日 | 2005-12-09 | | 公開日 | 2006-02-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Basis of the Nucleotide Driven Conformational Changes in the Aaa(+) Domain of Transcription Activator Pspf.
J.Mol.Biol., 357, 2006
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4R2P
 | | Wilms Tumor Protein (WT1) zinc fingers in complex with hydroxymethylated DNA | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5HC)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5HC)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), ... | | 著者 | Hashimoto, H, Olanrewaju, Y.O, Zheng, Y, Wilson, G.G, Zhang, X, Cheng, X. | | 登録日 | 2014-08-12 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.788 Å) | | 主引用文献 | Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.
Genes Dev., 28, 2014
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4R2A
 | | Egr1/Zif268 zinc fingers in complex with methylated DNA | | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*GP*CP*GP*TP*GP*GP*GP*(5CM)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*CP*GP*C)-3'), ... | | 著者 | Hashimoto, H, Olanrewaju, Y.O, Zheng, Y, Wilson, G.G, Zhang, X, Cheng, X. | | 登録日 | 2014-08-11 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.591 Å) | | 主引用文献 | Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.
Genes Dev., 28, 2014
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2C98
 | | Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, PSP OPERON TRANSCRIPTIONAL ACTIVATOR | | 著者 | Rappas, M, Schumacher, J, Niwa, H, Buck, M, Zhang, X. | | 登録日 | 2005-12-09 | | 公開日 | 2006-02-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Basis of the Nucleotide Driven Conformational Changes in the Aaa(+) Domain of Transcription Activator Pspf.
J.Mol.Biol., 357, 2006
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