1SQO
Substituted 2-Naphthamidine Inhibitors of Urokinase
Summary for 1SQO
Entry DOI | 10.2210/pdb1sqo/pdb |
Related | 1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SQA 1SQT |
Descriptor | Urokinase-type plasminogen activator, SULFATE ION, 8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMIDE, ... (4 entities in total) |
Functional Keywords | plasminogen activation, hydrolase, serine protease, glycoprotein, kringle, egf-like domain |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 1 |
Total formula weight | 28188.01 |
Authors | Wendt, M.D.,Geyer, A.,McClellan, W.J.,Rockway, T.W.,Weitzberg, M.,Zhao, X.,Mantei, R.,Stewart, K.,Nienaber, V.,Klinghofer, V.,Giranda, V.L. (deposition date: 2004-03-19, release date: 2004-04-27, Last modification date: 2011-07-13) |
Primary citation | Wendt, M.D.,Geyer, A.,McClellan, W.J.,Rockway, T.W.,Weitzberg, M.,Zhao, X.,Mantei, R.,Stewart, K.,Nienaber, V.,Klinghofer, V.,Giranda, V.L. Interaction with the S1beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors. Bioorg.Med.Chem.Lett., 14:3063-3068, 2004 Cited by PubMed: 15149645PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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