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1OWI

Substituted 2-Naphthamidine Inhibitors of Urokinase

Summary for 1OWI
Entry DOI10.2210/pdb1owi/pdb
Related1FV9 1OWD 1OWE 1OWH 1OWJ 1OWK
DescriptorUrokinase-type plasminogen activator, 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE (2 entities in total)
Functional Keywordsplasminogen activation, hydrolase, serine protease, glycoprotein, kringle, egf-like domain
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P00749
Total number of polymer chains1
Total formula weight27995.94
Authors
Wendt, M.D.,Rockway, T.W.,Geyer, A.,McClellan, W.,Weitzberg, M.,Zhao, X.,Mantei, R.,Nienaber, V.L.,Stewart, K.,Klinghofer, V.,Giranda, V.L. (deposition date: 2003-03-28, release date: 2003-09-30, Last modification date: 2017-10-11)
Primary citationWendt, M.D.,Rockway, T.W.,Geyer, A.,McClellan, W.,Weitzberg, M.,Zhao, X.,Mantei, R.,Nienaber, V.L.,Stewart, K.,Klinghofer, V.,Giranda, V.L.
Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution.
J.Med.Chem., 47:303-324, 2004
Cited by
PubMed: 14711304
DOI: 10.1021/jm0300072
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.93 Å)
Structure validation

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