7U2T
 
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7U2Q
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5C7X
 | | Crystal structure of MOR04357, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF | | 分子名称: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, DI(HYDROXYETHYL)ETHER, Granulocyte-macrophage colony-stimulating factor, ... | | 著者 | Eylenstein, R, Weinfurtner, D, Steidl, S, Boettcher, J, Augustin, M. | | 登録日 | 2015-06-25 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody.
Mabs, 8, 2016
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5D71
 | | Crystal structure of MOR04302, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF | | 分子名称: | DI(HYDROXYETHYL)ETHER, Granulocyte-macrophage colony-stimulating factor, Immunglobulin G1 Fab fragment, ... | | 著者 | Eylenstein, R, Weinfurtner, D, Steidl, S, Boettcher, J, Augustin, M. | | 登録日 | 2015-08-13 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody.
Mabs, 8, 2016
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5D72
 | | Crystal structure of MOR04252, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF | | 分子名称: | DI(HYDROXYETHYL)ETHER, Granulocyte-macrophage colony-stimulating factor, Immunglobulin G1 Fab fragment, ... | | 著者 | Eylenstein, R, Weinfurtner, D, Steidl, S, Boettcher, J, Augustin, M. | | 登録日 | 2015-08-13 | | 公開日 | 2015-10-14 | | 最終更新日 | 2016-01-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody.
Mabs, 8, 2016
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5D70
 | | Crystal structure of MOR03929, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF | | 分子名称: | Granulocyte-macrophage colony-stimulating factor, Immunglobulin G1 Fab fragment, heavy chain, ... | | 著者 | Eylenstein, R, Weinfurtner, D, Steidl, S, Boettcher, J, Augustin, M. | | 登録日 | 2015-08-13 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody.
Mabs, 8, 2016
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5D7S
 | | Crystal structure of MOR04357, a neutralizing anti-human GM-CSF antibody Fab fragment | | 分子名称: | (2S,3S)-butane-2,3-diol, Immunglobulin G1 Fab fragment, heavy chain, ... | | 著者 | Eylenstein, R, Weinfurtner, D, Steidl, S, Boettcher, J, Augustin, M. | | 登録日 | 2015-08-14 | | 公開日 | 2015-10-14 | | 最終更新日 | 2016-01-13 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody.
Mabs, 8, 2016
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4JPG
 | | 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as Novel PKM2 Activators | | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 2-(1H-benzimidazol-1-ylmethyl)-4H-pyrido[1,2-a]pyrimidin-4-one, Pyruvate kinase isozymes M1/M2 | | 著者 | Greasley, S.E, Hickey, M, Phonephaly, H, Cronin, C. | | 登録日 | 2013-03-19 | | 公開日 | 2013-05-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators.
Bioorg.Med.Chem.Lett., 23, 2013
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5WID
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5OL6
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5OL5
 | | Crystal structure of an inactivated Ssp SICLOPPS intein with CFAHPQ extein | | 分子名称: | 1,2-ETHANEDIOL, COBALT (II) ION, DNA polymerase III subunit alpha,DNA polymerase III subunit alpha, ... | | 著者 | Kick, L.M, Schneider, S. | | 登録日 | 2017-07-26 | | 公開日 | 2017-09-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.329 Å) | | 主引用文献 | Mechanistic Insights into Cyclic Peptide Generation by DnaE Split-Inteins through Quantitative and Structural Investigation.
Chembiochem, 18, 2017
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5OL7
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4XRA
 | | Salmonella typhimurium AhpC T43S mutant | | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... | | 著者 | Perkins, A, Brereton, A.E, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | | 登録日 | 2015-01-20 | | 公開日 | 2016-01-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
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4XRD
 | | Salmonella typhimurium AhpC W169F mutant | | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... | | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | | 登録日 | 2015-01-21 | | 公開日 | 2016-01-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
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4XS4
 | | Salmonella typhimurium AhpC C165S mutant | | 分子名称: | Alkyl hydroperoxide reductase subunit C, POTASSIUM ION | | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | | 登録日 | 2015-01-21 | | 公開日 | 2016-01-27 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
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4XTS
 | | Salmonella typhimurium AhpC T43A mutant | | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION | | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | | 登録日 | 2015-01-24 | | 公開日 | 2016-01-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.704 Å) | | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
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4XS6
 | | Salmonella typhimurium AhpC W81F mutant | | 分子名称: | Alkyl hydroperoxide reductase subunit C, POTASSIUM ION | | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | | 登録日 | 2015-01-21 | | 公開日 | 2016-01-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
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4XS1
 | | Salmonella typhimurium AhpC T43V mutant | | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... | | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | | 登録日 | 2015-01-21 | | 公開日 | 2016-01-27 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
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5UKA
 | | Salmonella typhimurium AhpC E49Q mutant | | 分子名称: | Alkyl hydroperoxide reductase subunit C, CHLORIDE ION, POTASSIUM ION, ... | | 著者 | Perkins, A, Nelson, K, Parsonage, D, Poole, L, Karplus, P.A. | | 登録日 | 2017-01-20 | | 公開日 | 2018-01-24 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Antioxid.Redox Signal., 28, 2018
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7KNA
 | | Localized reconstruction of the H1 A/Michigan/45/2015 ectodomain displayed at the surface of I53_dn5 nanoparticle | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin,I53_dn5 | | 著者 | Acton, O.J, Park, Y.J, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2020-11-04 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Quadrivalent influenza nanoparticle vaccines induce broad protection.
Nature, 592, 2021
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3QF7
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3QG5
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2H62
 | | Crystal structure of a ternary ligand-receptor complex of BMP-2 | | 分子名称: | Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA | | 著者 | Mueller, T.D. | | 登録日 | 2006-05-30 | | 公開日 | 2007-04-10 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
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2H64
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