5D71

Crystal structure of MOR04302, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF

Summary for 5D71

Entry DOI	10.2210/pdb5d71/pdb
Descriptor	Granulocyte-macrophage colony-stimulating factor, Immunglobulin G1 Fab fragment, heavy chain, Immunglobulin G1 Fab fragment, light chain, ... (6 entities in total)
Functional Keywords	gm-csf, affinity maturation, phage display, cytokine, antibody, proteros biostructures gmbh, immune system
Biological source	Homo sapiens (Human) More
Cellular location	Secreted: P04141
Total number of polymer chains	3
Total formula weight	64158.72
Authors	Eylenstein, R.,Weinfurtner, D.,Steidl, S.,Boettcher, J.,Augustin, M. (deposition date: 2015-08-13, release date: 2015-10-14, Last modification date: 2024-01-10)
Primary citation	Eylenstein, R.,Weinfurtner, D.,Hartle, S.,Strohner, R.,Bottcher, J.,Augustin, M.,Ostendorp, R.,Steidl, S. Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody. Mabs, 8:176-186, 2016 Cited by PubMed: 26406987 DOI: 10.1080/19420862.2015.1099774 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation