5D71

Crystal structure of MOR04302, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005129	molecular_function	granulocyte macrophage colony-stimulating factor receptor binding
A	0005576	cellular_component	extracellular region
A	0006955	biological_process	immune response
A	0008083	molecular_function	growth factor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PEG H 301

Chain	Residue
H	PRO126
H	SER127
H	SER128
H	THR135
H	ALA137

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site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 L 301

Chain	Residue
L	ASP93
L	ASP1
L	ILE2
L	LYS31
L	GLY92

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site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 L 302

Chain	Residue
L	GLU83
L	VAL106
L	GLY107
L	GLN108
L	TYR140
L	LYS166
L	HOH428

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
L	TYR191-HIS197
H	TYR194-HIS200

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site_id	PS00702
Number of Residues	9
Details	GM_CSF Granulocyte-macrophage colony-stimulating factor signature. CPPTpETsC

Chain	Residue	Details
A	CYS88-CYS96

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:1737041

Chain	Residue	Details
A	SER5
A	SER7
A	SER9

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) threonine; partial => ECO:0000269|PubMed:1737041

Chain	Residue	Details
A	THR10

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
A	ASN27
A	ASN37

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