5D71

Crystal structure of MOR04302, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005129	molecular_function	granulocyte macrophage colony-stimulating factor receptor binding
A	0005576	cellular_component	extracellular region
A	0006955	biological_process	immune response
A	0008083	molecular_function	growth factor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PEG H 301

Chain	Residue
H	PRO126
H	SER127
H	SER128
H	THR135
H	ALA137

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 L 301

Chain	Residue
L	ASP93
L	ASP1
L	ILE2
L	LYS31
L	GLY92

---

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 L 302

Chain	Residue
L	GLU83
L	VAL106
L	GLY107
L	GLN108
L	TYR140
L	LYS166
L	HOH428

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
L	TYR191-HIS197
H	TYR194-HIS200

---

site_id	PS00702
Number of Residues	9
Details	GM_CSF Granulocyte-macrophage colony-stimulating factor signature. CPPTpETsC

Chain	Residue	Details
A	CYS88-CYS96

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) serine","evidences":[{"source":"PubMed","id":"1737041","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GalNAc...) threonine; partial","evidences":[{"source":"PubMed","id":"1737041","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

---