5D71

Crystal structure of MOR04302, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Granulocyte-macrophage colony-stimulating factor	polymer	144	16309.7	1	UniProt (P04141) Pfam (PF01109)	Homo sapiens (Human)	GM-CSF,Colony-stimulating factor,CSF,Molgramostin,Sargramostim
2	B (H)	Immunglobulin G1 Fab fragment, heavy chain	polymer	236	25321.0	1		Homo sapiens (Human)
3	C (L)	Immunglobulin G1 Fab fragment, light chain	polymer	209	22229.7	1		Homo sapiens (Human)
4	D (H)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
5	E, F (L)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	G, H, I (A, H, L)	water	water		18.0	198	Chemie (HOH)

Sequence modifications

A: -16 - 110 (UniProt: P04141)

PDB	External Database	Details
Lys 111	-	expression tag
Asp 112	-	expression tag
Phe 113	-	expression tag
Leu 114	-	expression tag
Leu 115	-	expression tag
Val 116	-	expression tag
Ile 117	-	expression tag
Pro 118	-	expression tag
Phe 119	-	expression tag
Asp 120	-	expression tag
Cys 121	-	expression tag
Trp 122	-	expression tag
Glu 123	-	expression tag
Pro 124	-	expression tag
Val 125	-	expression tag
Gln 126	-	expression tag
Glu 127	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	63860.5
Non-Polymers*	Number of molecules	3
	Total formula weight	298.2
All*	Total formula weight	64158.7

*Water molecules are not included.