5D7S

Crystal structure of MOR04357, a neutralizing anti-human GM-CSF antibody Fab fragment

Summary for 5D7S

• Entry DOI: 10.2210/pdb5d7s/pdb
• Descriptor: Immunglobulin G1 Fab fragment, light chain, Immunglobulin G1 Fab fragment, heavy chain, (2S,3S)-butane-2,3-diol, ... (4 entities in total)
• Functional Keywords: gm-csf, affinity maturation, phage display, cytokine, antibody, proteros biostructures gmbh, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 47868.24

Authors

Eylenstein, R.,Weinfurtner, D.,Steidl, S.,Boettcher, J.,Augustin, M. (deposition date: 2015-08-14, release date: 2015-10-14, Last modification date: 2016-01-13)

• Primary citation: Eylenstein, R.,Weinfurtner, D.,Hartle, S.,Strohner, R.,Bottcher, J.,Augustin, M.,Ostendorp, R.,Steidl, S.; Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody.; Mabs, 8:176-186, 2016; PubMed: 26406987; DOI: 10.1080/19420862.2015.1099774

Experimental method

X-RAY DIFFRACTION (1.88 Å)