5D72
Crystal structure of MOR04252, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF
Summary for 5D72
Entry DOI | 10.2210/pdb5d72/pdb |
Descriptor | Granulocyte-macrophage colony-stimulating factor, Immunglobulin G1 Fab fragment, heavy chain, Immunglobulin G1 Fab fragment, light chain, ... (5 entities in total) |
Functional Keywords | gm-csf, affinity maturation, phage display, cytokine, antibody, proteros biostructures gmbh, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P04141 |
Total number of polymer chains | 6 |
Total formula weight | 127494.76 |
Authors | Eylenstein, R.,Weinfurtner, D.,Steidl, S.,Boettcher, J.,Augustin, M. (deposition date: 2015-08-13, release date: 2015-10-14, Last modification date: 2016-01-13) |
Primary citation | Eylenstein, R.,Weinfurtner, D.,Hartle, S.,Strohner, R.,Bottcher, J.,Augustin, M.,Ostendorp, R.,Steidl, S. Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody. Mabs, 8:176-186, 2016 Cited by PubMed: 26406987DOI: 10.1080/19420862.2015.1099774 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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