5D72

Crystal structure of MOR04252, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF

Summary for 5D72

Entry DOI	10.2210/pdb5d72/pdb
Descriptor	Granulocyte-macrophage colony-stimulating factor, Immunglobulin G1 Fab fragment, heavy chain, Immunglobulin G1 Fab fragment, light chain, ... (5 entities in total)
Functional Keywords	gm-csf, affinity maturation, phage display, cytokine, antibody, proteros biostructures gmbh, immune system
Biological source	Homo sapiens (Human) More
Cellular location	Secreted: P04141
Total number of polymer chains	6
Total formula weight	127494.76
Authors	Eylenstein, R.,Weinfurtner, D.,Steidl, S.,Boettcher, J.,Augustin, M. (deposition date: 2015-08-13, release date: 2015-10-14, Last modification date: 2016-01-13)
Primary citation	Eylenstein, R.,Weinfurtner, D.,Hartle, S.,Strohner, R.,Bottcher, J.,Augustin, M.,Ostendorp, R.,Steidl, S. Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody. Mabs, 8:176-186, 2016 Cited by PubMed: 26406987 DOI: 10.1080/19420862.2015.1099774 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation