5D72

Crystal structure of MOR04252, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Granulocyte-macrophage colony-stimulating factor	polymer	141	15953.3	2	UniProt (P04141) Pfam (PF01109) In PDB	Homo sapiens (Human)	GM-CSF,Colony-stimulating factor,CSF,Molgramostin,Sargramostim
2	H, M	Immunglobulin G1 Fab fragment, heavy chain	polymer	238	25458.3	2		Homo sapiens (Human)
3	L, N	Immunglobulin G1 Fab fragment, light chain	polymer	209	22229.6	2		Homo sapiens (Human)
4	H, N	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
5		water	water		18.0	32	Chemie (HOH)

Sequence modifications

A, B: -16 - 110 (UniProt: P04141)

PDB	External Database	Details
Lys 111	-	expression tag
Asp 112	-	expression tag
Phe 113	-	expression tag
Leu 114	-	expression tag
Leu 115	-	expression tag
Val 116	-	expression tag
Ile 117	-	expression tag
Pro 118	-	expression tag
Phe 119	-	expression tag
Asp 120	-	expression tag
Cys 121	-	expression tag
Trp 122	-	expression tag
Glu 123	-	expression tag
Pro 124	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	127282.5
Non-Polymers*	Number of molecules	2
	Total formula weight	212.2
All*	Total formula weight	127494.8

*Water molecules are not included.