7P6X
| Cryo-Em structure of the hexameric RUVBL1-RUVBL2 in complex with ZNHIT2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | 著者 | Llorca, O, Serna, M, Fernandez-Leiro, R. | 登録日 | 2021-07-18 | 公開日 | 2021-12-15 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8. Nucleic Acids Res., 50, 2022
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8F5V
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8FX9
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2ZXX
| Crystal structure of Cdt1/geminin complex | 分子名称: | DNA replication factor Cdt1, Geminin | 著者 | Cho, Y, Lee, C, Hong, B.S, Choi, J.M. | 登録日 | 2009-01-08 | 公開日 | 2009-02-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for inhibition of the replication licensing factor Cdt1 by geminin Nature, 430, 2004
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7WWY
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7WWT
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7WX0
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7WX1
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6Z4H
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6Z4L
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6Z4G
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6Z3V
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6Z4I
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6Z4O
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6LUT
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3FZD
| Mutation of Asn28 disrupts the enzymatic activity and dimerization of SARS 3CLpro | 分子名称: | 3C-like proteinase | 著者 | Barrila, J, Gabelli, S, Bacha, U, Amzel, L.M, Freire, E. | 登録日 | 2009-01-25 | 公開日 | 2010-05-05 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) . Biochemistry, 49, 2010
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6FE6
| Solution structure of a last generation P2-P4 macrocyclic inhibitor | 分子名称: | (3aR,7S,10S,12R,24aR)-7-cyclopentyl-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-5,8-dioxo-1,2,3,3a,5,6,7,8,11,12,20,21,22,23,24,24a-hexadecahydro-10H-9,12-methanocyclopenta[18,19][1,10,3,6]dioxadiazacyclononadecino[12,11-b]quinoline-10-carboxamide, Non-structural 3 protease, ZINC ION | 著者 | Gallo, M, Eliseo, T, Cicero, D.O. | 登録日 | 2017-12-29 | 公開日 | 2019-01-30 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a last generation macrocyclic inhibitor. Hepatitis C virus NS3 protease complex: when S prime region occupancy is not enough to stabilize the protein conformation in the absence of NS4A. To Be Published
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4LVC
| Crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii in complex with adenosine | 分子名称: | ACETATE ION, ADENOSINE, AMMONIUM ION, ... | 著者 | Manszewski, T, Singh, K, Imiolczyk, B, Jaskolski, M. | 登録日 | 2013-07-26 | 公開日 | 2014-07-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | An enzyme captured in two conformational states: crystal structure of S-adenosyl-L-homocysteine hydrolase from Bradyrhizobium elkanii. Acta Crystallogr.,Sect.D, 71, 2015
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5W4G
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2NTD
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3FKR
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5G0T
| InhA in complex with a DNA encoded library hit | 分子名称: | 1-benzyl-N-[cis-4-(2-{[(4-fluorophenyl)methyl][2-(methylamino)-2-oxoethyl]amino}-2-oxoethyl)cyclohexyl]-5-methyl-1H-1,2,3-triazole-4-carboxamide, ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Read, J.A, Breed, J. | 登録日 | 2016-03-22 | 公開日 | 2016-11-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Discovery of Cofactor-Specific, Bactericidal Mycobacterium Tuberculosis Inha Inhibitors Using DNA-Encoded Library Technology Proc.Natl.Acad.Sci.USA, 113, 2016
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4BPD
| Structure determination of an integral membrane kinase | 分子名称: | (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, DIACYLGLYCEROL KINASE, ZINC ION | 著者 | Li, D, Boland, C, Caffrey, M. | 登録日 | 2013-05-24 | 公開日 | 2014-05-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Cell-Free Expression and in Meso Crystallisation of an Integral Membrane Kinase for Structure Determination. Cell.Mol.Life Sci., 71, 2014
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6R77
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3PI5
| Crystal Structure of Human Beta Secretase in Complex with BFG356 | 分子名称: | (3S,4S,5R)-3-(3-bromo-4-hydroxybenzyl)-5-[(3-cyclopropylbenzyl)amino]tetrahydro-2H-thiopyran-4-ol 1,1-dioxide, Beta-secretase 1 | 著者 | Rondeau, J.M. | 登録日 | 2010-11-05 | 公開日 | 2011-03-23 | 最終更新日 | 2017-03-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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