6Z4H

A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 2 in P21 space group

This is a large structure.

Summary for 6Z4H

DescriptorSuperoxide dismutase [Cu-Zn], ZINC ION, ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide, ... (5 entities in total)
Functional Keywordssod1, ebselen, motor neuron disease, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight32814.32
Authors
Amporndanai, K.,Hasnain, S.S. (deposition date: 2020-05-25, release date: 2020-09-16)
Primary citation
Amporndanai, K.,Rogers, M.,Watanabe, S.,Yamanaka, K.,O'Neill, P.M.,Hasnain, S.S.
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis.
Ebiomedicine, 59:102980-102980, 2020
PubMed: 32862101 (PDB entries with the same primary citation)
DOI: 10.1016/j.ebiom.2020.102980
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.255300 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
168889
PDB entries from 2020-09-16