6Z4G

A4V mutant of human SOD1 bound with ebselen in P21 space group

This is a large structure.

Summary for 6Z4G

DescriptorSuperoxide dismutase [Cu-Zn], ZINC ION, ACETATE ION, ... (7 entities in total)
Functional Keywordssod1, ebselen, motor neuron disease, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight33098.49
Authors
Amporndanai, K.,Hasnain, S.S. (deposition date: 2020-05-25, release date: 2020-09-16)
Primary citation
Amporndanai, K.,Rogers, M.,Watanabe, S.,Yamanaka, K.,O'Neill, P.M.,Hasnain, S.S.
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis.
Ebiomedicine, 59:102980-102980, 2020
PubMed: 32862101 (PDB entries with the same primary citation)
DOI: 10.1016/j.ebiom.2020.102980
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.45 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19940 0.9% 0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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169436
PDB entries from 2020-09-30