A4V mutant of human SOD1 bound with N-aryl benzoisoselenazolone derivative 13 in P21 space group

This is a large structure.

Summary for 6Z3V

DescriptorSuperoxide dismutase [Cu-Zn], ZINC ION, 5-fluoranyl-~{N}-(3-morpholin-4-ylcarbonylphenyl)-2-selanyl-benzamide, ... (5 entities in total)
Functional Keywordssod1, motor neuron disease, ebselen, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight33267.77
Amporndanai, K.,Hasnain, S.S. (deposition date: 2020-05-22, release date: 2020-09-16)
Primary citation
Amporndanai, K.,Rogers, M.,Watanabe, S.,Yamanaka, K.,O'Neill, P.M.,Hasnain, S.S.
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis.
Ebiomedicine, 59:102980-102980, 2020
PubMed: 32862101 (PDB entries with the same primary citation)
DOI: 10.1016/j.ebiom.2020.102980
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20010 0.8% 2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16