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4F5H
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BU of 4f5h by Molmil
Intercoversion of Substrate Specificity: E. coli Aspatate Aminotransferase to Tyrosine Aminotransferase: Chimera P3.
分子名称: Aspartate aminotransferase
著者Addington, T.A, Fisher, A.J, Toney, M.D.
登録日2012-05-13
公開日2013-02-13
最終更新日2013-04-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4F5L
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BU of 4f5l by Molmil
A Theoretical Optimized Mutant for the Conversion of Substrate Specificity and Activity of Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P7.
分子名称: 1,2-ETHANEDIOL, Aspartate aminotransferase
著者Addington, T.A, Fisher, A.J, Toney, M.D.
登録日2012-05-13
公開日2013-05-15
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Janus: an algorithm for ranking functional importance of residues from protein sequence alignments.
To be Published
5TSB
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BU of 5tsb by Molmil
Crystal structure of the Zrt-/Irt-like protein from Bordetella bronchiseptica with bound Cd2+
分子名称: CADMIUM ION, Membrane protein
著者Zhang, T, Fellner, M, Sui, D, Liu, J, Hu, J.
登録日2016-10-28
公開日2017-09-20
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structures of a ZIP zinc transporter reveal a binuclear metal center in the transport pathway.
Sci Adv, 3, 2017
4F5J
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BU of 4f5j by Molmil
Rational Design and Directed Evolution for Conversion of Substrate Specificity from E.coli Aspartate Aminotransferase to Tyrosine Aminotransferase: Mutant P5.
分子名称: Aspartate aminotransferase
著者Addington, T.A, Fisher, A.J, Toney, M.D.
登録日2012-05-13
公開日2013-02-13
最終更新日2013-04-24
実験手法X-RAY DIFFRACTION (1.954 Å)
主引用文献Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4F5F
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BU of 4f5f by Molmil
Structure of Aspartate Aminotransferase Conversion to Tyrosine Aminotransferase: Chimera P1.
分子名称: Aspartate aminotransferase
著者Addington, T.A, Fisher, A.J, Toney, M.D.
登録日2012-05-13
公開日2013-02-13
最終更新日2013-04-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4F5M
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BU of 4f5m by Molmil
Wild-Type E. coli Aspartate Aminotransferase: A Template For The Interconversion of Substrate Specificity and Activity To Tyrosine Aminotransferase By The JANUS Algorithm.
分子名称: 1,2-ETHANEDIOL, Aspartate aminotransferase
著者Addington, T.A, Fisher, A.J, Toney, M.D.
登録日2012-05-13
公開日2013-02-13
最終更新日2013-04-24
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
4F5I
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BU of 4f5i by Molmil
Substrate Specificity Conversion of E. coli Pyridoxal-5'-Phosphate Dependent Aspartate Aminotransferase to Tyrosine Aminotransferase: Chimera P4.
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Aspartate aminotransferase
著者Addington, T.A, Fisher, A.J, Toney, M.D.
登録日2012-05-13
公開日2013-02-13
最終更新日2013-04-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
J.Mol.Biol., 425, 2013
8P1U
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BU of 8p1u by Molmil
Structure of divisome complex FtsWIQLB
分子名称: Cell division protein FtsB, Cell division protein FtsL, Cell division protein FtsQ, ...
著者Yang, L, Chang, S, Tang, D, Dong, H.
登録日2023-05-12
公開日2024-05-22
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural insights into the activation of the divisome complex FtsWIQLB.
Cell Discov, 10, 2024
7VKK
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BU of 7vkk by Molmil
Crystal structure of D. melanogaster SAMTOR V66W/E67P mutant
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-adenosylmethionine sensor upstream of mTORC1, SULFATE ION
著者Zhang, T, Ding, J.
登録日2021-09-30
公開日2022-07-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling.
Sci Adv, 8, 2022
7VKR
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Crystal structure of D. melanogaster SAMTOR in complex with SAM
分子名称: CITRIC ACID, S-ADENOSYLMETHIONINE, S-adenosylmethionine sensor upstream of mTORC1
著者Tang, X, Zhang, T, Ding, J.
登録日2021-09-30
公開日2022-07-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling.
Sci Adv, 8, 2022
7VKQ
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BU of 7vkq by Molmil
Crystal structure of D. melanogaster SAMTOR in the SAH bound form
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, S-adenosylmethionine sensor upstream of mTORC1
著者Tang, X, Zhang, T, Ding, J.
登録日2021-09-30
公開日2022-07-20
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.094 Å)
主引用文献Molecular mechanism of S -adenosylmethionine sensing by SAMTOR in mTORC1 signaling.
Sci Adv, 8, 2022
8IN8
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BU of 8in8 by Molmil
Cryo-EM structure of the target ssDNA-bound SIR2-APAZ/Ago-gRNA quaternary complex
分子名称: DNA (5'-D(P*AP*AP*CP*GP*AP*CP*GP*TP*CP*TP*AP*AP*GP*AP*AP*AP*CP*CP*AP*TP*TP*AP*A)-3'), MAGNESIUM ION, Piwi domain protein, ...
著者Zhang, H, Li, Z, Yu, G.M, Li, X.Z, Wang, X.S.
登録日2023-03-08
公開日2023-07-05
最終更新日2023-09-13
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into mechanisms of Argonaute protein-associated NADase activation in bacterial immunity.
Cell Res., 33, 2023
8XKN
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BU of 8xkn by Molmil
Cryo-EM structure of tail tube protein
分子名称: a protein
著者Zhang, H, Li, Z, Li, X.Z.
登録日2023-12-23
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Insights into the modulation of bacterial NADase activity by phage proteins.
Nat Commun, 15, 2024
8WKN
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BU of 8wkn by Molmil
Cryo-EM structure of DSR2-DSAD1
分子名称: SIR2-like domain-containing protein, SPbeta prophage-derived uncharacterized protein YotI
著者Zhang, H, Li, Z, Li, X.Z.
登録日2023-09-28
公開日2024-05-01
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Insights into the modulation of bacterial NADase activity by phage proteins.
Nat Commun, 15, 2024
7CJF
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BU of 7cjf by Molmil
Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody heavy chain, ...
著者Guo, Y, Li, X, Zhang, G, Fu, D, Schweizer, L, Zhang, H, Rao, Z.
登録日2020-07-10
公開日2020-11-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.108 Å)
主引用文献A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes.
Nat Commun, 12, 2021
5ZTC
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BU of 5ztc by Molmil
Apo structure of TetR family transcription regulator Lmo2088 of Listeria monocytogenes EGDe
分子名称: Lmo2088 protein, PENTAETHYLENE GLYCOL
著者Samad, A, Jin, T.
登録日2018-05-02
公開日2019-06-12
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献X-ray crystal structure of putative transcription regulator lmo2088 from Listeria monocytogenes.
Biochem.Biophys.Res.Commun., 520, 2019
4NI9
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BU of 4ni9 by Molmil
Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025), FORM 2
分子名称: Interleukin-6, SODIUM ION, SOMAmer SL1025
著者Davies, D, Edwards, T, Gelinas, A, Jarvis, T, Clifton, M.C.
登録日2013-11-05
公開日2014-01-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.
J.Biol.Chem., 289, 2014
4NI7
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BU of 4ni7 by Molmil
Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025)
分子名称: Interleukin-6, SODIUM ION, SOMAmer SL1025
著者Davies, D, Edwards, T, Gelinas, A, Jarvis, T, Clifton, M.C.
登録日2013-11-05
公開日2014-01-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.
J.Biol.Chem., 289, 2014
4PXQ
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BU of 4pxq by Molmil
Crystal structure of D-glucuronyl C5-epimerase in complex with heparin hexasaccharide
分子名称: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, D-glucuronyl C5 epimerase B
著者Ke, J, Qin, Y, Gu, X, Tan, J, Brunzelle, J.S, Xu, H.E, Ding, K.
登録日2014-03-24
公開日2015-01-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
6BL9
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BU of 6bl9 by Molmil
NMR Solution structure of U-SLPTX15-Sm2a
分子名称: Sm2a toxin
著者Harvey, P.J, Craik, D.J, Durek, T, Dash, T.J.
登録日2017-11-09
公開日2018-11-14
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献A Centipede Toxin Family Defines an Ancient Class of CS alpha beta Defensins.
Structure, 27, 2019
4PW2
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BU of 4pw2 by Molmil
Crystal structure of D-glucuronyl C5 epimerase
分子名称: CITRIC ACID, D-glucuronyl C5 epimerase B
著者Ke, J, Qin, Y, Gu, X, Brunzelle, J.S, Xu, H.E, Ding, K.
登録日2014-03-18
公開日2015-01-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
8WD8
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BU of 8wd8 by Molmil
Cryo-EM structure of TtdAgo-guide DNA-target DNA complex
分子名称: Argonaute family protein, Guide DNA, MAGNESIUM ION, ...
著者Zhuang, L.
登録日2023-09-14
公開日2024-01-31
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute.
Mol.Cell, 84, 2024
8WCE
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BU of 8wce by Molmil
Cryo-EM structure of a protein-RNA complex
分子名称: MAGNESIUM ION, RNA (31-MER), RNA (66-MER), ...
著者Li, Z.
登録日2023-09-11
公開日2024-05-22
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献Molecular mechanism for target RNA recognition and cleavage of Cas13h.
Nucleic Acids Res., 52, 2024
8X3R
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BU of 8x3r by Molmil
Crystal structure of human WDR5 in complex with WDR5
分子名称: WD repeat-containing protein 5
著者Liu, Y, Huang, X.
登録日2023-11-14
公開日2024-05-29
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献The NTE domain of PTEN alpha / beta promotes cancer progression by interacting with WDR5 via its SSSRRSS motif.
Cell Death Dis, 15, 2024
8XFD
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BU of 8xfd by Molmil
Crystal structure of pyruvate kinase tetramer in complex with allosteric activator, Mitapivat (MTPV, AG-348)
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, Isoform L-type of Pyruvate kinase PKLR, MAGNESIUM ION, ...
著者Sun, R, Achour, A.
登録日2023-12-13
公開日2024-05-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348
Crystals, 2024

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