2KCK
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![BU of 2kck by Molmil](/molmil-images/mine/2kck) | NMR solution structure of the Northeast Structural Genomics Consortium (NESG) target MrR121A | 分子名称: | TPR repeat | 著者 | Barb, A.W, Lee, H.-W, Wang, X, Lee, D, Jiang, M, Ciccosanti, C, Xiao, R, Nair, R, Everett, J.K, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Prestegard, J.H, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-12-22 | 公開日 | 2009-01-27 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR structure of the Northeast Structural Genomics Target MrR121A To be Published
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8IYX
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![BU of 8iyx by Molmil](/molmil-images/mine/8iyx) | Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365 | 分子名称: | 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid, Probable G-protein coupled receptor 34,YL-365 | 著者 | Jia, G.W, Wang, X, Zhang, C.B, Dong, H.H, Su, Z.M. | 登録日 | 2023-04-06 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120, 2023
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4MH7
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![BU of 4mh7 by Molmil](/molmil-images/mine/4mh7) | Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1896 | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-butyl-2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-methylpyrimidine-5-carboxamide, ... | 著者 | Zhang, W, McIver, A, Stashko, M.A, Deryckere, D, Branchford, B.R, Hunter, D, Kireev, D.B, Miley, M.J, Norris-Drouin, J, Stewart, W.M, Lee, M, Sather, S, Zhou, Y, DiPaola, J.A, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem., 56, 2013
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2PQ6
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2KS6
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2N6F
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![BU of 2n6f by Molmil](/molmil-images/mine/2n6f) | Structure of Pleiotrophin | 分子名称: | Pleiotrophin | 著者 | Ryan, E.O, Shen, D, Wang, X. | 登録日 | 2015-08-20 | 公開日 | 2016-04-20 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural studies reveal an important role for the pleiotrophin C-terminus in mediating interactions with chondroitin sulfate. Febs J., 283, 2016
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2N62
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![BU of 2n62 by Molmil](/molmil-images/mine/2n62) | ddFLN5+110 | 分子名称: | gelation factor, secretion monitor chimera | 著者 | Cabrita, L.D, Cassaignau, A.M.E, Launay, H.M.M, Waudby, C.A, Camilloni, C, Robertson, A.L, Wang, X, Wlodarski, T, Wentink, A.S, Vendruscolo, M, Dobson, C.M, Christodoulou, J. | 登録日 | 2015-08-10 | 公開日 | 2016-03-02 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding. Nat.Struct.Mol.Biol., 23, 2016
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5YC0
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![BU of 5yc0 by Molmil](/molmil-images/mine/5yc0) | Crystal structure of LP-46/N44 | 分子名称: | Envelope glycoprotein, LP-46 | 著者 | Zhang, X, Wang, X, He, Y. | 登録日 | 2017-09-05 | 公開日 | 2018-02-14 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Exceptional potency and structural basis of a T1249-derived lipopeptide fusion inhibitor against HIV-1, HIV-2, and simian immunodeficiency virus J. Biol. Chem., 293, 2018
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7E5S
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![BU of 7e5s by Molmil](/molmil-images/mine/7e5s) | SARS-CoV-2 S trimer with four-antibody cocktail complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FC05 heavy chain, FC05 light chain, ... | 著者 | Sun, Y, Wang, L, Wang, N, Feng, R, Wang, X. | 登録日 | 2021-02-20 | 公開日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms. Cell Res., 31, 2021
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7E5R
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![BU of 7e5r by Molmil](/molmil-images/mine/7e5r) | SARS-CoV-2 S trimer with three-antibody cocktail complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FC05 heavy chain, FC05 light chain, ... | 著者 | Sun, Y, Wang, L, Wang, N, Feng, R, Wang, X. | 登録日 | 2021-02-20 | 公開日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms. Cell Res., 31, 2021
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7EVM
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![BU of 7evm by Molmil](/molmil-images/mine/7evm) | Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex | 分子名称: | CHOLESTEROL, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cong, Z, Chen, L, Ma, H, Zhou, Q, Zou, X, Ye, C, Dai, A, Liu, Q, Huang, W, Sun, X, Wang, X, Xu, P, Zhao, L, Xia, T, Zhong, W, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2021-05-21 | 公開日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021
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7F3Q
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![BU of 7f3q by Molmil](/molmil-images/mine/7f3q) | SARS-CoV-2 RBD in complex with A5-10 Fab and A34-2 Fab | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of A34-2 Fab, ... | 著者 | Dou, Y, Wang, X, Liu, P, Lu, B, Wang, K. | 登録日 | 2021-06-16 | 公開日 | 2022-06-22 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Development of neutralizing antibodies against SARS-CoV-2, using a high-throughput single-B-cell cloning method. Antib Ther, 6, 2023
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7DUQ
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![BU of 7duq by Molmil](/molmil-images/mine/7duq) | Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex | 分子名称: | CHOLESTEROL, Glucagon-like peptide 1, Glucagon-like peptide 1 receptor, ... | 著者 | Cong, Z, Chen, L, Ma, H, Zhou, Q, Zou, X, Ye, C, Dai, A, Liu, Q, Huang, W, Sun, X, Wang, X, Xu, P, Zhao, L, Xia, T, Zhong, W, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2021-01-11 | 公開日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021
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7DUR
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![BU of 7dur by Molmil](/molmil-images/mine/7dur) | Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex | 分子名称: | CHOLESTEROL, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cong, Z, Chen, L, Ma, H, Zhou, Q, Zou, X, Ye, C, Dai, A, Liu, Q, Huang, W, Sun, X, Wang, X, Xu, P, Zhao, L, Xia, T, Zhong, W, Yang, D, Xu, H.E, Zhang, Y, Wang, M. | 登録日 | 2021-01-11 | 公開日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021
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6LTH
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![BU of 6lth by Molmil](/molmil-images/mine/6lth) | Structure of human BAF Base module | 分子名称: | AT-rich interactive domain-containing protein 1A, SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, ... | 著者 | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | 登録日 | 2020-01-22 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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6MEP
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![BU of 6mep by Molmil](/molmil-images/mine/6mep) | Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC3437 | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Tyrosine-protein kinase Mer, ... | 著者 | Da, C, Zhang, D, Stashko, M.A, Cheng, A, Hunter, D, Norris-Drouin, J, Graves, L, Machius, M, Miley, M.J, DeRyckere, D, Earp, H.S, Graham, D.K, Frye, S.V, Wang, X, Kireev, D. | 登録日 | 2018-09-06 | 公開日 | 2019-09-11 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.893 Å) | 主引用文献 | Data-Driven Construction of Antitumor Agents with Controlled Polypharmacology. J.Am.Chem.Soc., 141, 2019
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7D7N
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![BU of 7d7n by Molmil](/molmil-images/mine/7d7n) | Cryo-EM structure of human ABCB6 transporter | 分子名称: | ATP-binding cassette sub-family B member 6, mitochondrial | 著者 | Wang, C, Cao, C, Wang, N, Wang, X, Zhang, X.C. | 登録日 | 2020-10-05 | 公開日 | 2020-10-21 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Cryo-electron microscopy structure of human ABCB6 transporter. Protein Sci., 29, 2020
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6N04
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![BU of 6n04 by Molmil](/molmil-images/mine/6n04) | The X-ray crystal structure of AbsH3, an FAD dependent reductase from the Abyssomicin biosynthesis pathway in Streptomyces | 分子名称: | AbsH3, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Clinger, J.A, Wang, X, Cai, W, Miller, M.D, Van Lanen, S.G, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2018-11-06 | 公開日 | 2019-11-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | The crystal structure of AbsH3: A putative flavin adenine dinucleotide-dependent reductase in the abyssomicin biosynthesis pathway. Proteins, 2020
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6NO8
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6LTJ
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![BU of 6ltj by Molmil](/molmil-images/mine/6ltj) | Structure of nucleosome-bound human BAF complex | 分子名称: | AT-rich interactive domain-containing protein 1A, Actin, cytoplasmic 1, ... | 著者 | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | 登録日 | 2020-01-22 | 公開日 | 2020-02-12 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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7D7R
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![BU of 7d7r by Molmil](/molmil-images/mine/7d7r) | Cryo-EM structure of the core domain of human ABCB6 transporter | 分子名称: | ATP-binding cassette sub-family B member 6, mitochondrial | 著者 | Wang, C, Cao, C, Wang, N, Wang, X, Zhang, X.C. | 登録日 | 2020-10-05 | 公開日 | 2020-10-21 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-electron microscopy structure of human ABCB6 transporter. Protein Sci., 29, 2020
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5ZMY
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![BU of 5zmy by Molmil](/molmil-images/mine/5zmy) | Crystal structure of a cis-epoxysuccinate hydrolase producing D(-)-tartaric acids | 分子名称: | Cis-epoxysuccinate hydrolase, D(-)-TARTARIC ACID, ZINC ION | 著者 | Dong, S, Liu, X, Wang, X, Feng, Y. | 登録日 | 2018-04-06 | 公開日 | 2018-08-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structural insight into the catalytic mechanism of a cis-epoxysuccinate hydrolase producing enantiomerically pure d(-)-tartaric acid. Chem. Commun. (Camb.), 54, 2018
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5ZMU
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![BU of 5zmu by Molmil](/molmil-images/mine/5zmu) | Crystal structure of a cis-epoxysuccinate hydrolase producing D(-)-tartaric acids | 分子名称: | Cis-epoxysuccinate hydrolase, ZINC ION | 著者 | Dong, S, Liu, X, Wang, X, Feng, Y. | 登録日 | 2018-04-06 | 公開日 | 2018-08-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural insight into the catalytic mechanism of a cis-epoxysuccinate hydrolase producing enantiomerically pure d(-)-tartaric acid. Chem. Commun. (Camb.), 54, 2018
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6I2K
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![BU of 6i2k by Molmil](/molmil-images/mine/6i2k) | Structure of EV71 complexed with its receptor SCARB2 | 分子名称: | 1-(2-aminopyridin-4-yl)-3-[(3S)-5-{4-[(E)-(ethoxyimino)methyl]phenoxy}-3-methylpentyl]imidazolidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhou, D, Zhao, Y, Kotecha, A, Fry, E.E, Kelly, J, Wang, X, Rao, Z, Rowlands, D.J, Ren, J, Stuart, D.I. | 登録日 | 2018-11-01 | 公開日 | 2018-11-28 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2. Nat Microbiol, 4, 2019
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6JHR
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![BU of 6jhr by Molmil](/molmil-images/mine/6jhr) | The cryo-EM structure of HAV bound to a neutralizing antibody-F6 | 分子名称: | FAB Heavy Chain, FAB Light Chain, VP1, ... | 著者 | Cao, L, Liu, P, Yang, P, Gao, Q, Li, H, Sun, Y, Zhu, L, Lin, J, Su, D, Rao, Z, Wang, X. | 登録日 | 2019-02-18 | 公開日 | 2020-03-18 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors. Plos Biol., 17, 2019
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