6NO8
PIM1 in complex with Cpd9 ((R)-5-amino-N-(3-(4-aminoazepan-1-yl)-1H-pyrazol-4-yl)-2-(2,6-difluorophenyl)thiazole-4-carboxamide)
Summary for 6NO8
Entry DOI | 10.2210/pdb6no8/pdb |
Descriptor | Serine/threonine-protein kinase pim-1, 5-amino-N-{5-[(4S)-4-aminoazepan-1-yl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32060.27 |
Authors | Murray, J.M.,wang, X. (deposition date: 2019-01-15, release date: 2019-11-27, Last modification date: 2023-10-11) |
Primary citation | Murray, J.M.,Wang, X. Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma To be published, |
Experimental method | X-RAY DIFFRACTION (2.377 Å) |
Structure validation
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