6I2K

Structure of EV71 complexed with its receptor SCARB2

Summary for 6I2K

• Entry DOI: 10.2210/pdb6i2k/pdb
• EMDB information: 0332
• Descriptor: Polyprotein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 1-(2-aminopyridin-4-yl)-3-[(3S)-5-{4-[(E)-(ethoxyimino)methyl]phenoxy}-3-methylpentyl]imidazolidin-2-one, ... (12 entities in total)
• Functional Keywords: enterovirus 71, scarb2, hand-foot-mouth disease, ev71 receptor, virus
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 147035.46

Authors

Zhou, D.,Zhao, Y.,Kotecha, A.,Fry, E.E.,Kelly, J.,Wang, X.,Rao, Z.,Rowlands, D.J.,Ren, J.,Stuart, D.I. (deposition date: 2018-11-01, release date: 2018-11-28, Last modification date: 2020-07-29)

• Primary citation: Zhou, D.,Zhao, Y.,Kotecha, A.,Fry, E.E.,Kelly, J.T.,Wang, X.,Rao, Z.,Rowlands, D.J.,Ren, J.,Stuart, D.I.; Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.; Nat Microbiol, 4:414-419, 2019; PubMed: 30531980; DOI: 10.1038/s41564-018-0319-z

Experimental method

ELECTRON MICROSCOPY (3.4 Å)