7WP1
 
 | | Cryo-EM structure of SARS-CoV-2 Mu S6P trimer in complex with neutralizing antibody VacW-209 (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, VacW-209 heavy chain, ... | | 著者 | Zheng, Q, Sun, H, Ju, B, Zhang, Z, Li, S, Xia, N. | | 登録日 | 2022-01-22 | | 公開日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | | 主引用文献 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209.
Cell Res., 32, 2022
|
|
7WP5
 | | Cryo-EM structure of SARS-CoV-2 Omicron S6P trimer in complex with neutralizing antibody VacW-209 (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spikeprotein S1, VacW-209 heavy chain, ... | | 著者 | Zheng, Q, Sun, H, Ju, B, Zhang, Z, Li, S, Xia, N. | | 登録日 | 2022-01-22 | | 公開日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209.
Cell Res., 32, 2022
|
|
7WON
 | | Cryo-EM structure of SARS-CoV-2 S2P trimer in complex with neutralizing antibody VacW-209 (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, VacW-209 heavy chain, ... | | 著者 | Zheng, Q, Sun, H, Ju, B, Zhang, Z, Li, S, Xia, N. | | 登録日 | 2022-01-22 | | 公開日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209.
Cell Res., 32, 2022
|
|
7WP2
 | | Cryo-EM structure of SARS-CoV-2 C.1.2 S6P trimer in complex with neutralizing antibody VacW-209 (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, VacW-209 heavy chain, ... | | 著者 | Zheng, Q, Sun, H, Ju, B, Zhang, Z, Li, S, Xia, N. | | 登録日 | 2022-01-22 | | 公開日 | 2022-07-20 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209.
Cell Res., 32, 2022
|
|
7WP0
 | | Cryo-EM structure of SARS-CoV-2 Delta S6P trimer in complex with neutralizing antibody VacW-209 (local refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IG c335_light_IGLV1-40_IGLJ3, Spike protein S1, ... | | 著者 | Zheng, Q, Sun, H, Ju, B, Zhang, Z, Li, S, Xia, N. | | 登録日 | 2022-01-22 | | 公開日 | 2022-07-20 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209.
Cell Res., 32, 2022
|
|
7WQH
 | | Crystal structure of HCoV-NL63 main protease with PF07304814 | | 分子名称: | 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | | 著者 | Zhong, F.L, Zhou, X.L, Lin, C, Zeng, P, Li, J, Zhang, J. | | 登録日 | 2022-01-25 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814
J.Mol.Biol., 434, 2022
|
|
7EZG
 | | The structure of the human METTL6 enzyme in complex with SAH | | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, tRNA N(3)-methylcytidine methyltransferase METTL6 | | 著者 | Xie, W, Chen, R, Zhou, J, Liu, L. | | 登録日 | 2021-06-01 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of human METTL6, the m 3 C methyltransferase.
Commun Biol, 4, 2021
|
|
6MO5
 | | Co-Crystal structure of P. aeruginosa LpxC-50228 complex | | 分子名称: | MAGNESIUM ION, N-[(2S)-1-(hydroxyamino)-3-methyl-3-{[(oxetan-3-yl)methyl]sulfonyl}-1-oxobutan-2-yl]-4-(6-hydroxyhexa-1,3-diyn-1-yl)benzamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase | | 著者 | Stein, A.J, Holt, M.C, Assar, Z, Cohen, F, Andrews, L, Cirz, R. | | 登録日 | 2018-10-04 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | | 主引用文献 | Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Chemmedchem, 14, 2019
|
|
6MOO
 | | Co-Crystal structure of P. aeruginosa LpxC-achn975 complex | | 分子名称: | N-[(2S)-3-azanyl-3-methyl-1-(oxidanylamino)-1-oxidanylidene-butan-2-yl]-4-[4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta -1,3-diynyl]benzamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION | | 著者 | Stein, A.J, Assar, Z, Holt, M.C, Cohen, F, Andrews, L, Cirz, R. | | 登録日 | 2018-10-04 | | 公開日 | 2019-07-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Chemmedchem, 14, 2019
|
|
6MO4
 | | Co-Crystal structure of P. aeruginosa LpxC-50067 complex | | 分子名称: | MAGNESIUM ION, N-[(2R)-1-(hydroxyamino)-3-methyl-3-(methylsulfonyl)-1-oxobutan-2-yl]-4-(6-hydroxyhexa-1,3-diyn-1-yl)benzamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase | | 著者 | Stein, A.J, Assar, Z, Holt, M.C, Cohen, F, Andrews, L, Cirz, R. | | 登録日 | 2018-10-04 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.844 Å) | | 主引用文献 | Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Chemmedchem, 14, 2019
|
|
6MOD
 | | Co-Crystal structure of P. aeruginosa LpxC-50432 complex | | 分子名称: | GLYCEROL, MAGNESIUM ION, N-[(1S)-2-(hydroxyamino)-1-(3-methoxy-1,1-dioxo-1lambda~6~-thietan-3-yl)-2-oxoethyl]-4-(6-hydroxyhexa-1,3-diyn-1-yl)benzamide, ... | | 著者 | Stein, A.J, Holt, M.C, Assar, Z, Cohen, F, Andrews, L, Cirz, R. | | 登録日 | 2018-10-04 | | 公開日 | 2019-07-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
Chemmedchem, 14, 2019
|
|
7W9N
 | | THE STRUCTURE OF OBA33-OTA COMPLEX | | 分子名称: | (2~{S})-2-[[(3~{R})-5-chloranyl-3-methyl-8-oxidanyl-1-oxidanylidene-3,4-dihydroisochromen-7-yl]carbonylamino]-3-phenyl-propanoic acid, OTA DNA APTAMER (33-MER) | | 著者 | Xu, G.H, Li, C.G. | | 登録日 | 2021-12-10 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Insights into the Mechanism of High-Affinity Binding of Ochratoxin A by a DNA Aptamer.
J.Am.Chem.Soc., 144, 2022
|
|
7XMV
 | | E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A(AMP/ADP) filament bound with ADP, AMP and R5P | | 分子名称: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | | 登録日 | 2022-04-27 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Filamentation modulates allosteric regulation of PRPS.
Elife, 11, 2022
|
|
7XN3
 | | E.coli phosphoribosylpyrophosphate (PRPP) synthetase type B filament bound with Pi | | 分子名称: | PHOSPHATE ION, Ribose-phosphate pyrophosphokinase | | 著者 | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | | 登録日 | 2022-04-27 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Filamentation modulates allosteric regulation of PRPS.
Elife, 11, 2022
|
|
7XMU
 | | E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A filament bound with ADP, Pi and R5P | | 分子名称: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | | 登録日 | 2022-04-26 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Filamentation modulates allosteric regulation of PRPS.
Elife, 11, 2022
|
|
7YK1
 | | Structural basis of human PRPS2 filaments | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Lu, G.M, Hu, H.H, Liu, J.L. | | 登録日 | 2022-07-21 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Structural basis of human PRPS2 filaments.
Cell Biosci, 13, 2023
|
|
7WQJ
 | | Crystal structure of MERS main protease in complex with PF07304814 | | 分子名称: | 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate | | 著者 | Lin, C, Zhang, J, Li, J. | | 登録日 | 2022-01-25 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814
J.Mol.Biol., 434, 2022
|
|
7DFT
 | | Crystal structure of Xanthomonas oryzae ClpP | | 分子名称: | ATP-dependent Clp protease proteolytic subunit, CHLORIDE ION | | 著者 | Yang, C.-G, Yang, T. | | 登録日 | 2020-11-09 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections.
J.Agric.Food Chem., 69, 2021
|
|
7DFU
 | |
7DKM
 | | PHGDH covalently linked to oridonin | | 分子名称: | (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, CHLORIDE ION, D-3-phosphoglycerate dehydrogenase, ... | | 著者 | Sun, Q, Lei, Y. | | 登録日 | 2020-11-25 | | 公開日 | 2022-02-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors.
Cell.Mol.Life Sci., 79, 2021
|
|
7FIF
 | | Cryo-EM structure of the hedgehog release protein Disp from water bear (Hypsibius dujardini) | | 分子名称: | Protein dispatched-like protein 1 | | 著者 | Luo, Y, Wan, G, Wang, Q, Zhao, Y, Cong, Y, Li, D. | | 登録日 | 2021-07-31 | | 公開日 | 2021-09-08 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | | 主引用文献 | Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release.
Front Mol Biosci, 8, 2021
|
|
