7DKM

PHGDH covalently linked to oridonin

Summary for 7DKM

• Entry DOI: 10.2210/pdb7dkm/pdb
• Descriptor: D-3-phosphoglycerate dehydrogenase, (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (7 entities in total)
• Functional Keywords: inhibitor, complex, dehydrogenase, covalent, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 69967.63

Authors

Sun, Q.,Lei, Y. (deposition date: 2020-11-25, release date: 2022-02-02, Last modification date: 2023-11-29)

• Primary citation: Tan, Y.,Zhou, X.,Gong, Y.,Gou, K.,Luo, Y.,Jia, D.,Dai, L.,Zhao, Y.,Sun, Q.; Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors.; Cell.Mol.Life Sci., 79:27-27, 2021; PubMed: 34971423; DOI: 10.1007/s00018-021-04022-2

Experimental method

X-RAY DIFFRACTION (1.7 Å)