7DKM

PHGDH covalently linked to oridonin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	D-3-phosphoglycerate dehydrogenase	polymer	314	33971.1	2	UniProt (O43175) Pfam (PF00389) Pfam (PF02826) In PDB	Homo sapiens (Human)	3-PGDH,2-oxoglutarate reductase,Malate dehydrogenase
2	A	(1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one	non-polymer		366.4	1	Chemie (ODN)
3	A, B	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	2	Chemie (NAD)
4	A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	B	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	B	PENTAETHYLENE GLYCOL	non-polymer		238.3	1	Chemie (1PE)
7		water	water		18.0	473	Chemie (HOH)

Sequence modifications

A, B: 4 - 308 (UniProt: O43175)

PDB	External Database	Details
Met 3	-	initiating methionine
Leu 309	-	expression tag
Glu 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag
His 316	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67942.2
Non-Polymers*	Number of molecules	7
	Total formula weight	2025.5
All*	Total formula weight	69967.6

*Water molecules are not included.