7WQJ

Crystal structure of MERS main protease in complex with PF07304814

Summary for 7WQJ

• Entry DOI: 10.2210/pdb7wqj/pdb
• Descriptor: 3C-like proteinase, [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl)carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate (3 entities in total)
• Functional Keywords: viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Middle East respiratory syndrome-related coronavirus
• Total number of polymer chains: 2
• Total formula weight: 66057.44

Authors

Lin, C.,Zhang, J.,Li, J. (deposition date: 2022-01-25, release date: 2022-08-24, Last modification date: 2023-11-29)

• Primary citation: Li, J.,Lin, C.,Zhou, X.,Zhong, F.,Zeng, P.,McCormick, P.J.,Jiang, H.,Zhang, J.; Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814; J.Mol.Biol., 434:167706-, 2022; DOI: 10.1016/j.jmb.2022.167706

Experimental method

X-RAY DIFFRACTION (2.75 Å)