6MOO
Co-Crystal structure of P. aeruginosa LpxC-achn975 complex
Summary for 6MOO
Entry DOI | 10.2210/pdb6moo/pdb |
Descriptor | UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, N-[(2S)-3-azanyl-3-methyl-1-(oxidanylamino)-1-oxidanylidene-butan-2-yl]-4-[4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta -1,3-diynyl]benzamide, ... (4 entities in total) |
Functional Keywords | hydrolase lpxc pseudomonas aeruginosa, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 1 |
Total formula weight | 34141.94 |
Authors | Stein, A.J.,Assar, Z.,Holt, M.C.,Cohen, F.,Andrews, L.,Cirz, R. (deposition date: 2018-10-04, release date: 2019-07-17, Last modification date: 2023-10-11) |
Primary citation | Cohen, F.,Aggen, J.B.,Andrews, L.D.,Assar, Z.,Boggs, J.,Choi, T.,Dozzo, P.,Easterday, A.N.,Haglund, C.M.,Hildebrandt, D.J.,Holt, M.C.,Joly, K.,Jubb, A.,Kamal, Z.,Kane, T.R.,Konradi, A.W.,Krause, K.M.,Linsell, M.S.,Machajewski, T.D.,Miroshnikova, O.,Moser, H.E.,Nieto, V.,Phan, T.,Plato, C.,Serio, A.W.,Seroogy, J.,Shakhmin, A.,Stein, A.J.,Sun, A.D.,Sviridov, S.,Wang, Z.,Wlasichuk, K.,Yang, W.,Zhou, X.,Zhu, H.,Cirz, R.T. Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety. Chemmedchem, 14:1560-1572, 2019 Cited by PubMed: 31283109DOI: 10.1002/cmdc.201900287 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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