9EPZ
| Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3337 | 分子名称: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha, SULFATE ION, ... | 著者 | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2024-03-20 | 公開日 | 2024-05-01 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276, 2024
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9EPW
| Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGC3336 | 分子名称: | Casein kinase II subunit alpha, SULFATE ION, ~{N}-[(3-chloranyl-4-phenyl-phenyl)methyl]-2-[1-(3-methylquinolin-8-yl)sulfonylpiperidin-4-yl]ethanamine | 著者 | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2024-03-20 | 公開日 | 2024-05-01 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276, 2024
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9EQ1
| Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric ligand FGJM24 | 分子名称: | 1,2-ETHANEDIOL, Casein kinase II subunit alpha, SULFATE ION, ... | 著者 | Kraemer, A, Greco, F, Moeckel, J, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2024-03-20 | 公開日 | 2024-05-01 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276, 2024
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8VQX
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7AA9
| Structure of SCOC pT13/pT15 LIR motif bound to GABARAPL1 | 分子名称: | Gamma-aminobutyric acid receptor-associated protein-like 1, pT13/PT15 SCOC LIR | 著者 | Lee, R, Mouilleron, S, Wirth, M, Zhang, W, O Reilly, N, Dhira, J, Tooze, S. | 登録日 | 2020-09-03 | 公開日 | 2021-06-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity. J.Mol.Biol., 433, 2021
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7AA8
| Structure of SCOC LIR bound to GABARAP | 分子名称: | Chimera made of SCOC (6-23) + linker (GS) + GABARAP,Gamma-aminobutyric acid receptor-associated protein | 著者 | Lee, R, Mouilleron, S, Wirth, M, Zhang, W, O Reilly, N, Dhira, J, Tooze, S. | 登録日 | 2020-09-03 | 公開日 | 2021-06-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity. J.Mol.Biol., 433, 2021
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7AA7
| Structure of SCOC pS12/pS18 LIR motif bound to GABARAPL1 | 分子名称: | Gamma-aminobutyric acid receptor-associated protein-like 1, pS12/pS18 SCOC LIR, sulfoacetic acid | 著者 | Lee, R, Mouilleron, S, Wirth, M, Zhang, W, O Reilly, N, Dhira, J, Tooze, S. | 登録日 | 2020-09-03 | 公開日 | 2021-06-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Phosphorylation of the LIR Domain of SCOC Modulates ATG8 Binding Affinity and Specificity. J.Mol.Biol., 433, 2021
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1C94
| REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD. | 分子名称: | RETRO-GCN4 LEUCINE ZIPPER | 著者 | Mittl, P.R.E, Deillon, C.A, Sargent, D, Liu, N, Klauser, S, Thomas, R.M, Gutte, B, Gruetter, M.G. | 登録日 | 1999-07-30 | 公開日 | 2000-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure. Proc.Natl.Acad.Sci.USA, 97, 2000
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4XX4
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4Y33
| Crystal of NO66 in complex with Ni(II)and N-oxalylglycine (NOG) | 分子名称: | Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, N-OXALYLGLYCINE, NICKEL (II) ION | 著者 | Wang, C, Zhang, Q, Zang, J. | 登録日 | 2015-02-10 | 公開日 | 2015-10-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8. Acta Crystallogr.,Sect.D, 71, 2015
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4XX3
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4Y3O
| Crystal structure of Ribosomal oxygenase NO66 in complex with substrate Rpl8 peptide and Ni(II) and cofactor N-oxalyglycine | 分子名称: | ACETATE ION, Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66, GLYCEROL, ... | 著者 | Wang, C, Zhang, Q, Zang, J. | 登録日 | 2015-02-10 | 公開日 | 2015-10-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8. Acta Crystallogr.,Sect.D, 71, 2015
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6IRG
| Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class II | 分子名称: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | 著者 | Zhang, J, Chang, S, Zhang, X, Zhu, S. | 登録日 | 2018-11-12 | 公開日 | 2019-01-16 | 最終更新日 | 2019-06-05 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018
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6IRA
| Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8 | 分子名称: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | 著者 | Zhang, J, Chang, S, Zhang, X, Zhu, S. | 登録日 | 2018-11-12 | 公開日 | 2019-01-16 | 最終更新日 | 2019-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018
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6IRH
| Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class III | 分子名称: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | 著者 | Zhang, J, Chang, S, Zhang, X, Zhu, S. | 登録日 | 2018-11-12 | 公開日 | 2019-01-16 | 最終更新日 | 2019-06-05 | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | 主引用文献 | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018
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6IRF
| Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class I | 分子名称: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | 著者 | Zhang, J, Chang, S, Zhang, X, Zhu, S. | 登録日 | 2018-11-12 | 公開日 | 2019-01-16 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | 主引用文献 | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Cell Rep, 25, 2018
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7OTJ
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1CT1
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8UEL
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8WUA
| cryo-EM structure of human TMEM63A | 分子名称: | CSC1-like protein 1 | 著者 | Yang, D. | 登録日 | 2023-10-20 | 公開日 | 2024-01-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A monomeric structure of human TMEM63A protein. Proteins, 92, 2024
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6EIV
| DYRK1A in complex with JWD-065 | 分子名称: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[3-[[4-azanyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide | 著者 | Rothweiler, U. | 登録日 | 2017-09-19 | 公開日 | 2018-08-29 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. J. Med. Chem., 61, 2018
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6EIR
| DYRK1A in complex with XMD15-27-2 | 分子名称: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[4-[[4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide | 著者 | Rothweiler, U. | 登録日 | 2017-09-19 | 公開日 | 2018-08-29 | 最終更新日 | 2021-07-07 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. J. Med. Chem., 61, 2018
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6EIQ
| DYRK1A in complex with XMD14-124 | 分子名称: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, [4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]-phenyl-methanone | 著者 | Rothweiler, U. | 登録日 | 2017-09-19 | 公開日 | 2018-08-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. J. Med. Chem., 61, 2018
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6EIP
| DYRK1A in complex with XMD8-62e | 分子名称: | 4-[[(3~{R},7~{S})-2-cyclopentyl-9-methyl-8-oxidanylidene-2,9,12,14-tetrazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),10,12-trien-13-yl]amino]benzamide, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 著者 | Rothweiler, U. | 登録日 | 2017-09-19 | 公開日 | 2018-08-29 | 最終更新日 | 2018-09-26 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. J. Med. Chem., 61, 2018
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6EJ4
| DYRK1A in complex with XMD7-112 | 分子名称: | 3-(3-pyridin-3-yl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)aniline, Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 著者 | Rothweiler, U. | 登録日 | 2017-09-20 | 公開日 | 2018-08-29 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. J. Med. Chem., 61, 2018
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