6IVR
 
 | | Crystal structure of a membrane protein W16A | | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | | 登録日 | 2018-12-04 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
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6IVP
 | | Crystal structure of a membrane protein P262A | | 分子名称: | CHLORIDE ION, ZINC ION, bestrophin | | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | | 登録日 | 2018-12-04 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
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8ECY
 | | cryoEM structure of bovine bestrophin-2 and glutamine synthetase complex | | 分子名称: | Bestrophin, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Owji, A.P, Kittredge, A.K, Yang, T. | | 登録日 | 2022-09-02 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2 Å) | | 主引用文献 | Bestrophin-2 and glutamine synthetase form a complex for glutamate release.
Nature, 611, 2022
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6VX8
 | | bestrophin-2 Ca2+- unbound state 2 (EGTA only) | | 分子名称: | Bestrophin, CHLORIDE ION | | 著者 | Owji, A.P, Zhao, Q, Ji, C, Kittredge, A, Hopiavuori, A, Fu, Z, Ward, N, Clarke, O, Shen, Y, Zhang, Y, Hendrickson, W.A, Yang, T. | | 登録日 | 2020-02-21 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.33 Å) | | 主引用文献 | Structural and functional characterization of the bestrophin-2 anion channel.
Nat.Struct.Mol.Biol., 27, 2020
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6VX9
 | | bestrophin-2 Ca2+- unbound state 1 (EGTA only) | | 分子名称: | Bestrophin, CHLORIDE ION | | 著者 | Owji, A.P, Zhao, Q, Ji, C, Kittredge, A, Hopiavuori, A, Fu, Z, Ward, N, Clarke, O, Shen, Y, Zhang, Y, Hendrickson, W.A, Yang, T. | | 登録日 | 2020-02-21 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.17 Å) | | 主引用文献 | Structural and functional characterization of the bestrophin-2 anion channel.
Nat.Struct.Mol.Biol., 27, 2020
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6VX6
 | | bestrophin-2 Ca2+-bound state (250 nM Ca2+) | | 分子名称: | Bestrophin, CALCIUM ION, CHLORIDE ION | | 著者 | Owji, A.P, Zhao, Q, Ji, C, Kittredge, A, Hopiavuori, A, Fu, Z, Ward, N, Clarke, O, Shen, Y, Zhang, Y, Hendrickson, W.A, Yang, T. | | 登録日 | 2020-02-21 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural and functional characterization of the bestrophin-2 anion channel.
Nat.Struct.Mol.Biol., 27, 2020
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6VX5
 | | bestrophin-2 Ca2+- unbound state (250 nM Ca2+) | | 分子名称: | Bestrophin, CHLORIDE ION | | 著者 | Owji, A.P, Zhao, Q, Ji, C, Kittredge, A, Hopiavuori, A, Fu, Z, Ward, N, Clarke, O, Shen, Y, Zhang, Y, Hendrickson, W.A, Yang, T. | | 登録日 | 2020-02-21 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | | 主引用文献 | Structural and functional characterization of the bestrophin-2 anion channel.
Nat.Struct.Mol.Biol., 27, 2020
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7YG7
 | | Structure of the Spring Viraemia of Carp Virus ribonucleoprotein Complex | | 分子名称: | Nucleoprotein, RNA (99-mer) | | 著者 | Liu, B, Wang, Z.X, Yang, T, Yu, D.Q, Ouyang, Q. | | 登録日 | 2022-07-11 | | 公開日 | 2023-03-15 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structure of the Spring Viraemia of Carp Virus Ribonucleoprotein Complex Reveals Its Assembly Mechanism and Application in Antiviral Drug Screening.
J.Virol., 97, 2023
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7X1Z
 | | Structure of the phosphorylation-site double mutant S431E/T432E of the KaiC circadian clock protein | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock oscillator protein KaiC, MAGNESIUM ION | | 著者 | Han, X, Zhang, D.L, Hong, L, Yu, D.Q, Wu, Z.L, Yang, T, Rust, M.J, Tu, Y.H, Ouyang, Q. | | 登録日 | 2022-02-25 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex
Nat Commun, 14, 2023
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7X1Y
 | | Structure of the phosphorylation-site double mutant S431A/T432A of the KaiC circadian clock protein | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock oscillator protein KaiC, MAGNESIUM ION | | 著者 | Han, X, Zhang, D.L, Hong, L, Yu, D.Q, Wu, Z.L, Yang, T, Rust, M.J, Tu, Y.H, Ouyang, Q. | | 登録日 | 2022-02-25 | | 公開日 | 2023-04-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex
Nat Commun, 14, 2023
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7VPG
 | | Crystal structure of the C-terminal tail of SARS-CoV-1 Orf6 complex with human nucleoporin pair Rae1-Nup98 | | 分子名称: | Isoform 3 of Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor | | 著者 | Li, T, Guo, H, Yang, T, Wen, Y, Ji, X. | | 登録日 | 2021-10-17 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export.
Front Mol Biosci, 8, 2021
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7VPH
 | | Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98 | | 分子名称: | Isoform 3 of Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor | | 著者 | Li, T, Guo, H, Yang, T, Wen, Y, Ji, X. | | 登録日 | 2021-10-17 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1-Nup98 Complex to Compete With mRNA Nuclear Export.
Front Mol Biosci, 8, 2021
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7DCY
 | | Apo form of Mycoplasma genitalium RNase R | | 分子名称: | MAGNESIUM ION, Ribonuclease R | | 著者 | Abula, A, Quan, X, Li, X, Yang, T, Li, T, Chen, Q, Ji, X. | | 登録日 | 2020-10-27 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.972 Å) | | 主引用文献 | Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation.
Nucleic Acids Res., 49, 2021
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7DIC
 | | Mycoplasma genitalium RNase R in complex with single-stranded RNA | | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), Ribonuclease R | | 著者 | Abula, A, Quan, X, Li, X, Yang, T, Li, T, Chen, Q, Ji, X. | | 登録日 | 2020-11-18 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.242 Å) | | 主引用文献 | Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation.
Nucleic Acids Res., 49, 2021
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7DOL
 | | Mycoplasma genitalium RNase R in complex with double-stranded RNA | | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*AP*AP*AP*AP*AP*A)-3'), Ribonuclease R | | 著者 | Abula, A, Quan, X, Li, X, Yang, T, Li, T, Chen, Q, Ji, X. | | 登録日 | 2020-12-14 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | | 主引用文献 | Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation.
Nucleic Acids Res., 49, 2021
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7DID
 | | Mycoplasma genitalium RNase R in complex with ribose methylated single-stranded RNA | | 分子名称: | MAGNESIUM ION, RNA (5'-R(*AP*AP*AP*A)-3'), Ribonuclease R | | 著者 | Abula, A, Quan, X, Li, X, Yang, T, Li, T, Chen, Q, Ji, X. | | 登録日 | 2020-11-18 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation.
Nucleic Acids Res., 49, 2021
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6IVL
 | | Crystal structure of a membrane protein L259A | | 分子名称: | ACETIC ACID, CHLORIDE ION, Ibestrophin, ... | | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | | 登録日 | 2018-12-04 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
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6IVJ
 | | Crystal structure of a membrane protein G18A | | 分子名称: | ACETIC ACID, CHLORIDE ION, Ibestrophin, ... | | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | | 登録日 | 2018-12-04 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
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6IV2
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6JLF
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6IVN
 | | Crystal structure of a membrane protein G264A | | 分子名称: | CHLORIDE ION, GLUTAMIC ACID, Ibestrophin, ... | | 著者 | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | | 登録日 | 2018-12-04 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations.
Commun Biol, 2, 2019
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5X87
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8WGN
 | | Human dihydrofolate reductase (HsDHFR) complexed with NADPH and LA1 | | 分子名称: | (3~{E})-3-[[2-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]oxypropoxy]phenyl]methylidene]oxolan-2-one, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Vanichtanankul, J, Saeyang, T, Vitsupakorn, D, Decharuangsilp, S, Arwon, U, Yuthavong, Y, Kamchonwongpaisan, S. | | 登録日 | 2023-09-22 | | 公開日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Flexible 2,4-diaminopyrimidine bearing a butyrolactone as Plasmodium falciparum dihydrofolate reductase inhibitors
Bioorg.Chem., 2024
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8WGM
 | | Quadruple mutant Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S, N51I+C59R+S108N+I164L) complexed with LA1, NADPH and dUMP | | 分子名称: | (3~{E})-3-[[2-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]oxypropoxy]phenyl]methylidene]oxolan-2-one, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | | 著者 | Vanichtanankul, J, Saeyang, T, Vitsupakorn, D, Arwon, U, Decharuangsilp, S, Yuthavong, Y, Kamchonwongpaisan, S. | | 登録日 | 2023-09-22 | | 公開日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Flexible 2,4-diaminopyrimidine bearing a butyrolactone as Plasmodium falciparum dihydrofolate reductase inhibitors
Bioorg.Chem., 2024
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8YQ8
 | | Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS V1/S) complexed with FB8, NADPH and dUMP | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 4-[4-[4-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]oxybutoxy]phenyl]benzoic acid, Bifunctional dihydrofolate reductase-thymidylate synthase, ... | | 著者 | Vanichtanankul, J, Vitsupakorn, D, Saeyang, T, Arwon, U, Hoarau, M, Decharuangsilp, S, Kamchonwongpaisan, S, Yuthavong, Y. | | 登録日 | 2024-03-19 | | 公開日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Novel flexible biphenyl Pf DHFR inhibitors with improved antimalarial activity.
Rsc Med Chem, 15, 2024
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